Local Anesthetic Pharmacokinetic Flashcards
1
Q
Local Anesthetic Chemical structure
A
WB, Hydrophikkic tertiary amines
2
Q
LA Amide and metabolism
A
I before caine
Metabolized by Hepatic Microsomal P450
Rare allergy rxn of methylparaben perservative
3
Q
LA Ester nomenclature and metabolism
A
No I before caine
Metabolized by plasma cholinesterase
Para amino benzoic acid is a major metabolite which is a known allergen
4
Q
LA Onset factors
A
Nonionized hydrophobic molecules
Lower pka
Bicarbonate addition
Lipid soluablility
higher concentration of LA (esp procaine and 2 chloropropaine)
5
Q
LA Duration Factor
A
Inc Protein bonding Longer
Lower Vascularity are Longer (less systemic uptake)
Lower Vasodilation Rate (all except cocaine)
Higer Lipid Solubility
Pseudocholineesterase deficiency (esters)
Liver disease (amide)
