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Feb > Nex Car 19 > Flashcards

Nex Car 19 Flashcards

1
Q

What does CAR-T cell therapy stand for?

A

Chimeric Antigen Receptor T-cell therapy.

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2
Q

What is the first step in the CAR-T cell therapy process?

A

Collecting T cells from the patient’s blood through a process known as Apheresis.

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3
Q

What is the purpose of the chimeric antigen receptor (CAR)?

A

It is designed to recognize and bind to a specific antigen found on cancer cells.

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3
Q

What type of cells are extracted during the Apheresis process?

A

T cells, a type of white blood cell.

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4
Q

What happens to the T cells in the laboratory?

A

They are genetically modified to express a special protein called a chimeric antigen receptor (CAR) on their surface.

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4
Q

What is cytokine release syndrome?

A

It is a widespread activation of the immune system that can cause collateral damage to the body’s normal cells.

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4
Q

What is the final step of the CAR-T cell therapy process?

A

The expanded CAR-T cells are infused back into the patient’s bloodstream to identify and attack cancer cells that express the targeted antigen.

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4
Q

x is an indigenously developed CAR-T cell therapy for y-cell cancers.

A

NexCAR19 is an indigenously developed CAR-T cell therapy for B-cell cancers.; B

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5
Q

Which organization is responsible for setting standards for drugs, pharmaceuticals, and healthcare devices in India?

A

The Indian Pharmacopoeia Commission (IPC) is responsible for setting these standards and is an autonomous body.

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5
Q

Which regulatory body approved NexCAR19 for commercial use?

A

The Central Drugs Standard Control Organisation (CDSCO).

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5
Q

What are WBCs, and where are they produced?

A

WBCs, or leukocytes, are produced in the bone marrow and circulate in the blood and lymphatic system.

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5
Q

What has the Ministry of Health and Family Welfare been publishing since 1955?

A

Since 1955, the Ministry has regularly published the Indian Pharmacopoeia.

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5
Q

What is the theme for World Cancer Day 2024?

A

The theme for World Cancer Day 2024 is “Close the care gap: Everyone deserves access to cancer care.”

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5
Q

Which organizations collaborated to develop NexCAR19?

A

ImmunoACT, Indian Institute of Technology Bombay (IIT-B), and Tata Memorial Hospital.

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5
Q

What are severe side effects associated with CAR-T cell therapy?

A

Severe side effects can include cytokine release syndrome and neurological symptoms.

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6
Q

Who is the current Minister of Health and Family Welfare?

A

The current Minister of Health and Family Welfare is Jagat Prakash Nadda.

6
Q

What is the duration of the campaign related to this theme?

A

The campaign runs for three years, from 2022 to 2024.

6
Q

What is the specific agenda for the year 2024 under this campaign?

A

The agenda for 2024 is “Together, we challenge those in power.”

6
Q

Who was India’s first Health Minister?

A

Rajkumari Amrit Kaur was India’s first Health Minister, serving from 1947 to 1957.

7
Q

When is World Cancer Day observed?

A

World Cancer Day is observed on February 4th.

8
Q

What are the official colors of World Cancer Day?

A

What are the official colors of World Cancer Day?

9
Q

Who was the first pediatric patient to receive CAR-T cell therapy?

A

Emily Whitehead was the first pediatric patient to receive CAR-T cell therapy.

10
Q

When was World Cancer Day established?

A

World Cancer Day was established on February 4, 2000.

11
Q

Who pioneered CAR-T cell therapy for B-cell malignancies?

A

Novartis pioneered the introduction of CAR-T cell therapy as an approved treatment for B-cell malignancies.

11
Q

What does Article x of the Charter state regarding World Cancer Day?

A

Article 10 of the Charter established February 4 as World Cancer Day to keep the Charter of Paris in the hearts and minds of people worldwide.

12
Q

What was the first approved CAR T cell therapy and for what condition was it used?

A

The first approved CAR T cell therapy was tisagenlecleucel, also known as Kymriah, developed by Novartis. It was approved by the FDA on August 30, 2017, for the treatment of pediatric and young adult acute lymphoblastic leukemia (ALL).

12
Q

Who was the first patient to be cured of cancer using India’s CAR-T cell therapy?

A

Answer: Dr. (Col) VK Gupta was the first patient to be cured of cancer using India’s CAR-T cell therapy.

12
Q

With which institution did Novartis partner to develop CAR-T cell therapy?

A

Novartis partnered with the University of Pennsylvania to develop CAR-T cell therapy.

13
Q

When was Immunoact established and who is the chair?

A

Established in 2018, and the chair is Rahul Purwar

14
Q

What is the official name of Car T cell

A

Actalycabtagene

15
Q

Drugs general of India

A

Rajeev Singh Raghuvanshi

Feb (28 decks)

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