NEUTRALIZATION (WEEK 5 PT1)

Question 1

Theory: propose by Suante ________
Any substance which releases H+ ions in the water solution. (Acids)

Any substance which releases OH- ions in the water solution. (Base)

Answer 1

Arrhenius Theory

Question 2

Theory: propose by Johannes Nicolaus _____ and Martin ______
it donates a proton (Acids)
it accepts a proton (Base)

Answer 2

Bronsted-Lowry Theory

Question 3

Theory: proposed by Gilbert N. _____
it accept an electron pair (Acids)
it donates an electron pair (Base)

Answer 3

Lewis theory

Question 4

substances that can both donate and accept protons depending on the conditions.

Answer 4

Amphiprotic

Question 5

substances are those that can act both as an acid and as a base.

Answer 5

Amphoteric

Question 6

Example of an Amphiprotic/ Amphoteric substances?

Answer 6

Water (H2O)

Question 7

a substance that accept the H+ ion of the base that donates H+ ion.

Answer 7

Conjugate Acid

Question 8

species that remains after the acid has donated its proton.

Answer 8

conjugate base

Question 9

Examples of strong acids:
So (Acids) H2SO4

Answer 9

Sulfuric Acid

Question 10

Examples of strong acids:
I- HI

Answer 10

Hydroiodic acid

Question 11

Examples of strong acids:
Brought- HBr

Answer 11

Hydrobromic Acid

Question 12

Examples of strong acids:

No- HNO3

Answer 12

Nitric acid

Question 13

Examples of strong acids:

Clean- HCl

Answer 13

Hydrochloric acid

Question 14

Examples of strong acids:

Clothes- HClO4

Answer 14

Perchloric Acid

Question 15

2 Analysis of compounds

Answer 15

Acidimetry
Alkalimetry

Question 16

– percentage potency, strength or
percentage purity of a drug or preparation.
- amount per 100

Answer 16

% Assay

Question 17

2 Types of Assay – number of titrant

Answer 17

Direct
Residual

Question 18

a base is being assayed using a
standard acid solution

Answer 18

Direct Acidimetry

Question 19

a base is being assayed with
a known excess of a (1st) standard acid,
where the excess acid is determined
by standard base (2nd)

Answer 19

RESIDUAL Acidimetry

Question 20

WHY Residual Titration happened?

Answer 20

-Sample is insoluble in water

-Reaction with standard solution is
slow

-Sample does not give a distinct
endpoint with an indicator by
direct titration

Question 21

if using an accurately measured volume of a standard alkali solutions

Answer 21

Direct Alkalimetry

Question 22

if the process requires adding an
excess of the (1) standard alkali solution and
determining the amount in excess by residual
titration with (2) standard acid solution

Answer 22

Residual Alkalimetry

Question 23

(g) = ml x N x meq

formula in what ?

Answer 23

Amount of pure substance

Question 24

ml (titrant) x N (titrant) x meq (Ana)
————————————————x 100
wt/ vol of sample (analyte)

Formula on what ?

Answer 24

% Assay

Question 25

is carried in the same manner as
the actual test BUT without the sample

Performed to correct errors due to:
* the presence of impurities in the reagents
* changes in volume at different temperature
* absorption of carbon dioxide by the alkali
* by the alkalinity imparted by the glass

Answer 25

Blank Determination

Question 26

what assay do perform a blank determination?

Answer 26

Assay of Aspirin capsule

Question 27

Assay of Aspirin capsule is called what type of assay ?

Answer 27

RESIDUAL ALKALIMETRIC ASSAY

Question 28

Assay of Acetic acid and Assay of Hydrochloric acid are called what type of assay?

Answer 28

DIRECT ALKALIMETRIC ASSAY

Question 29

Other examples of RESIDUAL ALKALIMETRIC ASSAY

Answer 29

Assay of Diluted Phosphoric Acid
Assay of Boric Acid
Assay of Tartaric acid
Assay of Ethyl acetate
Assay of Methyl salicylate
Assay of Chloral hydrate
Assay of Formaldehyde

Question 30

Aspirin + Base (NaoH) will from what 2 compound?

Answer 30

Sodium Acetyl Salicylate and water

Question 31

Sodium Acetyl Salicylate undergo what kind of process to form two by product ?

Answer 31

Hydrolysis

Question 32

Sodium Acetyl Salicylate + acid (H2SO4) form what 2 compound?

Answer 32

Sodium Salicylate and Acetic Acid