Neurotransmitters and Receptors Flashcards
-2 Types of synapses
Ion channels made up of?
What does this allow
3 Methods of achieving receptor diversity
Benefits of second messenger systems (3)
G protein coupled receptor messaging mechanis. What do they lack
How are G protein coupled receptors built
4 types of neurotransmitters
Glutamate general features
What does reuptake
Critical for?
3 Ionotropic receptors and 1 Metabotropic receptor for Glutamate
NMDA receptor permeable to
NMDA receptor co-agonist required
Function of Mg plug in NMDA receptor
NMDA characteristics of current
AMPA Receptor primary mediator of
Effect of repeated stimulation
Kainate
Effect of repeated stimulation
GABA general features
3 Receptor Types
GABAa receptor principle mediator of
what molecule does it gate?
Major allosteric modulators of GABAa receptor
GABAb receptor function
Receptor type
What molecules does it modulate
Drugs that work through GABAb receptor
Acetylcholine major function in PNS
Role in CNS?
Nicotinci ACh receptor composition
Differences between muscle type and neuron type receptor
Nicotinic ACh receptor expression in CNS and role in disease
Muscarinic ACh receptor role in Alzheimers
Muscarinic ACH receptor antagonists (2 functions)
Myasthenia gravis autoimmune response to
What does cholinergic system (especially muscarinic) regulate and what does this mean for parkinsons
Cholinergic toxins and the effect acronym
Anticholinergic molecules and effect
Two examples of Serotonin Neurotransmitters
4 examples of catecholamine receptors
What does dopamine bind to
Location of origin for Norepinephrine
Locus Coeruleus
Location of origin for dopamine
Ventral tegmental area and substantia nigra
location of origin for acetylcholine
Septal nuclei, nucleus basalis, pontomesencephalotegmental complex
location of origin for Serotonin
Raphe nuclei
Encephalitis is associated with?
Causes neurological deficits
