Neurobiology of peripheral nerves Flashcards
Importance of determining sensory and motor symptoms

Sensory Neurronopathies
Causes?

Neurogenic atrophy pathology

Neural response to Neurogenic atrophy

Type Grouping effect on electromyograph

Electrical activity of chronicaly denervated muscle

Amytotrophic Lateral Sclerosis
What muscles does this begin in

Spinal Muscular Atrophy physiology and cause

SMN1 and SMN2 genetic expression normally

Effect of replacing SMN1 by SMN2

Therapy to inhibit aberrant splicing of SMN2

Neuron response to chronic, severe ridiculopathy

Radiculopathy
Most common cause
most commonly affected levels

3 Anatomical causes of radiculopathies

Neuropathies
symptoms
abnormalities are norally?

Neuropathy Sensory loss progression

Neuropathy - dying back

Neuropathy - Length and Time dependence of axonal loss

Mutations affecting Motors, Road, Cargoes

PMP22 Role
Deletion -
Duplication
What chromosome is PMP22 on?

Peripheral Nerve inherited disease
General areas of disease causing mutations

Peripheral Nerve acquired disease
General areas of effect

Postsynaptic and Presynaptic response to repetitive stimulation
