Neuroscience of Schizophrenia Flashcards
1
Q
list the characteristic symptoms of schizophrenia
A
- delusions
- hallucinations
- disorganised speech
- disorganised behaviour
- negative symptoms
(must display at least 2)
2
Q
list the other aspects of the DSM 5 criteria in diagnosing
A
- social/occupational dysfunction
- duration 6 + months
- schizoaffective & major mood disorder
- substance/general mood condition
- relationship to development delay or ASD
3
Q
list positive symptoms
A
- hallucinations
- delusions
- disordered thought processes
- bizarre behaviours
4
Q
list negative symptoms
A
- social withdrawal
- flat affect
- loss of pleasurable feelings
- reduced speech
- reduced movement
5
Q
risk factors for schizophrenia
A
- nutrition
- infection e.g. rubella
- urban residence
- childhood trauma
- cannabis
- alcohol
6
Q
structural changes to brain with schizophrenia
A
- larger ventricles
- smaller hippocampus & amygdala
- thicker corpus callosum
- low frontal blood flow
- low activity at attention demanding tasks and active at rest at anterior cingulate cortex (mood, attention, emotional regulation)
7
Q
what does an increase in dopaminergic circuits lead to with symptoms
A
- delusions
- hallucinations
8
Q
what can glutamate inactivity mean for schizophrenia
A
- positive
- negative symptoms
9
Q
function of mesocorticolimbic pathway and the result of overactivity
A
connects limbic system with frontal cortex
- overactivity contributes to disordered thought, emotion and behaviour
10
Q
list the 3 treatments
A
- medication
- psychological treatment
- community treatment
11
Q
function of Phenothiazines medication
A
blocks D2 receptors to alleviate positive symptoms
