Neuroscience intro Flashcards
Rostral
towards nose
caudal
towards tail (rear)
dorsal
up from the back/spine
ventral
down from the belly
triune brain theory
evolution has added more complex areas of the brain
reptilian brain
developed about 100 million years ago, smell, aggression
limbic brain
developed about 50 million years ago, emotion, sex drive
cortex/neocortex
about 20 million years ago, refinement, reason, thought, social interaction
genes
contain coding and regulatory DNA
allele
alternate forms of the same gene
genotype
the combination of alleles present in one’s DNA
phenotype
the expression of the different alleles in the whole organism (ex: hair color)
neural stem cells
cells that produce pre-cursor cells
multi-potent
can self-renew and become a number of different cell types
toti-potent
can give rise to a new organism (ex: sperm and egg)
pluripotent
can become ANY type of new tissue
gastrulation
conversion of cells from a single layer to three layers of cells called germ layers
ectoderm
outer layer; gives rise to nervous system and skin
mesoderm
middle layer; starts the process of gastrulation; gives rise to muscle, bone, connective tissue
endoderm
inner layer; gives rise to viscera (organs, intestines)
what germ layers are important for orientation
mesoderm and endoderm
notochord
defines midline; critical for neural differentiation
neurulation
- ectoderm thickens into neural plate, which then becomes the neural tube
- breaks down and eventually become the nucleus pulposus
neural crest cells
- located dorsally on the neural groove
- give rise to sensory cells, autonomic nervous system, neurosecretory cells of the adrenal gland, and enteric neurons
neural tube
develops into drain and spinal cord
somites
mesoderm on inside, ectoderm on outside
3 primary brain vesicles
- prosencephalon
- mesencephalon
- rhombencephalon
prosencephalon
gives rise to forebrain
mesencephalon
gives rise to midbrain
rhombencephalon
gives rise to hindbrain
5 secondary brain vesicles
- telencephalon
- diencephalon
- mesencephalon
- metencephalon
- myelencephalon
telencephalon
formed by lateral aspects of rostral prosencephalon; most superior
dorsal territory of telencephalon
becomes cerebral cortex and hippocampus
ventral territory of telencephalon
becomes basal ganglia, basal forebrain nuclei, and olfactory bulb
diencephalon
- formed by caudal prosencephalon
- gives rise to thalamus and hypothalamus
- forms optic vesicles
mesencephalon
- dorsal portion: becomes the superior and inferior colliculi (brainstem)
- ventral portion: becomes the midbrain tegmentum
metencephalon
- formed by rostral portion of rhombencephalon
- gives rise to cerebellum and pons
myelencephalon
- formed by caudal part of the rhombencephalon
- gives rise to medulla