action potentials and synaptic tranmission Flashcards
amplitude
peak (not determined by strength)
- specific to neuron
strength
how frequently they fire
active transport
move ions against their concentration gradient
ion channels
- leakage channels
- gated channels
gated channel types
- voltage gated
- ligand gated
- mechanically gated
voltage gated ion channels
change in membrane potential causes channel to open
- crucial for generation and conduction of AP
ligand gated ion channels
chemical stimulus open and closes the channel
- G protein coupled and starts secondary process
mechanically gated ion channels
forces distort the channel which opens the gate
graded potentials
- small deviation from resting membrane potential
- can be in either hyper polarize or depolarize
- usually result of ligand gated or mechanically gated ion channels opening or closing
- most common in dendrites and cell bodies of neurons
- amplitude is determined by strength of stimulus
- not all or none
absolute refractory period
- unable to generate an AP even with a very strong stimulus
- inactivated Na channels cannot reopen
relative refractory period
- need a suprathreshold stimulus to generate another AP
- voltage gated K+ channels are still open, but Na channels have returned to resting state
electrical synapses
- ionic current passes directly from one cell to another cell through connexions in gap junctions
- fast
- synchronization
- two way transmission
chemical synapses
- 2 neurons separated by synaptic cleft
- voltage gated Ca channels open, Ca flows into presynaptic neuron
EPSP
depolarizes the postsynaptic cell to create an AP
IPSP
hyper polarizes the postsynaptic cell to inhibit generation of AP