Neuropsychological Flashcards
What was neuropsychology before it became a new separate discipline?
An area of clinical psychology
What does neuropsychology focus on?
The relationship between brain functioning and behaviour
What is a neuron?
a nerve cell
What is the central nervous system (CNS)?
The brain and the spinal cord
What is the peripheral nervous system (PNS)?
The neurons that convey messages to and from the rest of the body
What are the different sides of the brain called?
The cerebral hemispheres
What is it called when one side of the brain controls motor responses on the opposite side of the body?
Contralateral control
What is contralateral control?
When one side of the brain controls motor responses on the opposite side of the body
What is the rubbery casing around the axon called?
The myelin sheath
Is the resting potential of a cell negative or positive?
Slightly negative
When is the electrical voltage of a cell absent of a disturbance or stimulant?
When it is in resting potential
What does Na+ stand for?
Sodium
What does K+ stand for?
Potassium
What is the state of Na and K when in resting potential state?
Na+ gates are closed
K+ gates are nearly closed
What maintains an electrical gradient (a difference in electrical charge)?
The neuron membrane
What it hyperpolarisation?
When the electrical signal drops until the charge inside is considerably less than the outside
What is depolarisation?
Na+ flowing into the cell to make the electrical signal very positive
When do the Na+ gates fly open?
When the cell threshold is reached (after some Na+ has seeped in)
When do the Na+ gates snap shut?
When the cell is depolarised completed (full of Na+)
When do the K+ gates fly open?
When Na+ gates snap shut (when depolarised and cell is more positive than the outside)
What happens when the K+ gates fly open?
K+ can move out of the cell because its more positive inside than outside
What does the sodium potassium pump do?
Remove sodium and bring back potassium to restore back to resting potential
When does the sodium pump kick in?
When hyperpolarised
What are the specialised junctions between neurons called?
Synapses
When does synaptic transmission begin?
When the nerve impulse reaches the presynaptic axon terminal
What initiates the sequence of events that lead to the transmitter release and activation of receptors on the post synaptic membrane?
Depolarisation of the presynaptic membrane
What is an example of a neurotransmitter?
acetylcholine serotonin dopamine melatonin oxytocin glutamate
What do neurotransmitters do?
transmit signals from a neuron to a target cell across a synaptic cleft
Neurotransmitters can be classified based on whether they are:
Excitatory or inhibitory (some can be both depending on the receptor type)
Where is acetylcholine released?
In the CNS and the neuromuscular junction
What type of neurotransmitter do people with depression need more of?
serotonin
What do people with Schizophrenia have too much of?
dopamine
Less acetylcholine is sometimes associated with which mental disorder?
Alzheimers
Dopamine and norepinephrine imbalances are strongly related to which mental disorder?
ADHD
What are two examples of a psychostimulants?
Cocaine (increases dopamine)
Ecstasy (increases serotonin)
What are two types of opiate drugs?
Heroin (reduce GABA and increase dopamine)
Morphine (reduce GABA and increase dopamine)
What does acetylcholine do?
Activates skeletal muscles
What is the largest part of the brain?
Forebrain
What is the forebrain mainly made up of?
The cerebrum (the two cerebral hemispheres)
What is the white matter that connects the two hemispheres of the cerebrum?
The corpus callosum
Each hemisphere is divided into 4 lobes:
frontal, parietal, occipital and temporal
What are the temporal lobes in charge of?
auditory reception and processing visual information
What are the occipital lobes in charge of?
Visual reception
What are the parietal lobes in charge of?
Touch and bodily position
What are the frontal lobes in charge of?
Ordering and sorting information and motor skills (concentration, attention, planning, problem solving)
What is the area of the brain involved in regulation of breathing, balance and posture?
The cerebellum
What is the cerebellum in charge of?
Breathing, balance and posture
What is the area of the brain involved in regulation of eating, drinking, body temperature, sex and emotion?
Hypothalamus
What is the hypothalamus in charge of?
Regulation of eating, drinking, body temperature, sex and emotion
What is the area of the brain involved in expression of emotion?
The Lymbic system
What are the 3 parts of the lymbic system?
Amygdala, cingulate cortex and the hippocampus
What part of the brain was damanged in phineas gage?
The lymbic system
What are lesions?
changes to tissue resulting from injury or infection
Lesions manifest themselves in various behavioural deficits which include? (2)
Focal (at one site)
Diffuse (scattered across sites)
What is a hard sign?
A definite indicator of neurological deficit (e.g. through neuroimaging)
What is a soft sign?
An indicator suggestive of neurological deficit (e.g. inability to do something)
What are the 4 approaches to neuropsychology?
clinical
cognitive
neuroimaging
connectionist
What is involved in neuropsychological assessment?
History/ background check
Interviewing
Testing
What is the benefit of neurological assessment?
diagnosis improve treatment early intervention monitor progress discount malingering
What are the different types of memory?
immediate vs short term
delayed vs long term
working memory
What does WMS-IV stand for?
Weschler memory scale/ test
Why are there two types of batteries of the WMS?
different age groups
What are the Index scores derived from the WMS?
Auditory memory, Visual Memory, Visual Working Memory, Immediate Memory, and Delayed Memory
What is the RAVLT?
Rey Auditory Verbal Learning Test (for memory)
What are some confounds to memory assessment?
- Tiredness
- Physical issues (affecting praxis)
- Depression
- Drugs
- Anxiety & stress
- Thought disorders (seem functional until testing)
- ADD/ADHD
What are some tests for memory?
RAVLT
WMS
Wisconsin Card Sort
Clock Drawing task
What are some tests for executive function?
Rey Osterrieth Complex Figure
Trail making task
Tower of Hanoi
What is a test for language?
Boston Naming test
What would it indicate if someone was to adapt poorly to rule changes?
frontal-lobe lesions
What does perseverate mean?
To continue to respond in a previously correct fashion (to the previous rule)
Why is the clock task great for testing dementia?
Good daily task that could be done but may be missing details (signs of loss of executive function)
More Sensitive than MMSE
Good for early detection
What are the 3 conditions used in the ROCF (Rey Osterrieth Complex Figure) where participants have to draw figures?
Copy
Immediate Recall
Delayed Recall
In the example of an individual being referred for neuropsychological testing as a paramedic for reading what are your options?
- Give standardised tests and decide on the basis of these whether
there might be problems in the work environment. - Determine where there might be risks and devise a test to determine whether the risk exists.
What are some key red flags on the clock drawing task for people with dementia?
wrong time no hands missing numbers number substitutions Repetition refusal