Neuroplasticity (lab) Flashcards
1
Q
cognitive reserve
A
strucutral changes that support cognitive functioning
2
Q
Positive neuroplasticity
A
- structural changes in the brain that occur during novel and challenging stimuli
3
Q
Negative neuroplasticity
A
changes in the brain that occur if one experiences a lack of novel, challenging stimuli and diminished health
4
Q
Recovery after brain injury
types
A
- spontaneous: results from repair processes post lesion
- function-induced: occurs due to increase use of involved body segments in behaviorally relevant tasks
5
Q
Recovery vs compensation approaches to treatment
A
- bottom up approach emphasizes practice of desired skills to drive motor
recovery
of walking and UE functional use for ADLs - top-down approach involved teaching new
compensatory
strategies, requiring development of new skills
6
Q
What are the 10 principles of experience-dependent plasticity
A
- Use it or lose it
- use it and improve it
- specificity
- repetition matters
- intensity matters
- time matters best neuroplasticity is right after event
- salience matters
- age matters
- transference: transfer skills from one activity to another
- interference: tauhg something in one context and no transfered in another
7
Q
mechanism accounting for superior plasticicty in children
A
- persistence of neurogenesis in certain parts of brain during postnatal period
- elimination of neurons through apoptosis
- proliferation and runing of synpases
- activity dependent refinement of synpatic connections
8
Q
types of pediatric brain plasticity
A
- impaired plasticity
- excessive plasticity
- brain’s achilles hell plasticity
- adaptive plasticity
9
Q
Imparied plasticity
A
- genetic or acquired disorders disrupt plasticity pathways (changes in structures, synpases, NTs) and cause cognitive developmental disorders
- fragile X syndrome
- neurofibromatoisis 1
- tuberous sclerosis
- lead poisioning
- rett syndrome
10
Q
excessive plasticity
A
- leads to maladaptive brain circuits
- dystonia and rigidity following perinatal injury is related to an imbalance in NT systems that occurs with cortical reorganization in infants
- temporal lobe epilespy: too musch activity in temporal lobe
- Mesial temporal sclerosis: scarring within temporal lobe may be cause or result to TLE
11
Q
Plasticity as the brains achilles tendon
A
- areas of the brain that are rich in excitatory synpases
- including thalamus
- basal ganlia
- cortex
- are vulnerable to acute near total asphyxia in term infants
12
Q
adaptive plasticity
A
- activity-dependent changes in synpases and neuronal connections
- assoicated with acquisition of new motor skills
- learning a language or playing an instrument or sport
- also occurs during recovery from an injury or sensory loss
ex:
- eye patching for amblyopia(lazy eye)
- cochlear implants for hearing loss
- hemispherectomy for intractable seziures
13
Q
Neuroplasticity- based training and technologies
A
- CIMT and mCIMT
- microchips
- robotics
- virtual reality
- functional UE orthoses
- AFOs and LE FES
- locomotor training
14
Q
CIMT: constraint induced movement therapy
A
- functionally oriented task practice of affected UE and long periods of restraint of unaffected UE
- goal of treatment is pt based no therapist driven
- patients with excessive spasticity or pain in involved UE are exlcuded
- wear the mit for 23 hr/day
15
Q
CIMT: inclusion criteria
A
- ≥10º of active finger extension and ≥20ºof active wrist extension
- ≥3 months p/CVA nad ambulate without a device
- score ≥ 69 on modified mini mental status examination
- score < 2.5 on motor activity log