Autonomic Nervous system Flashcards
Divisions of the Autonomic NS
- sympathetic and parasympethic
- Also afferent and efferent connections
- innervates involuntary musucles glandular tissue
Function of the ANS
- regulates activity of internal organs and vasculature
- homeostasis: circulation, HR, BP, RR, digestion, secretions, temperature
- reproduction
Sensory receptors of the Autonomic NS
- mechanoreceptors
- chemoreceptors
- nocioceptors
- thermorecepetors
Similarities between somatic and Autonomic NS
- specialized afferents and efferents
- reflex connections
- ascending and descending connections to CNS
Differences between somatic and Autonomic NS
somatic
- thalamus receives most ascending info
- cerebral cortex is source of descending info
- one neuron system to PNS
autonomic
- hypothalamus receieves much of the ascending infor
- hypothalamus is source of descending info
- a two neuron system to PNS (a lightly myelinated axon to autonmic ganglia and unmyelinated axon to organ)
Afferent system
how does it enter the CNS
info from visceral receptors enters the CNS via two routes:
- into spinal cord via dorsal roots
- into brainstem via cranial nerves
Regulation of Autonomic NS
- viseral afferent to efferents = reflex is initiated via the afferent system
- visceral info enters the brainstem via cranial nerves to converge in the solitary nucleus
- solitary nucleus controls areas in pons and medulla and modulates areas in the hypothalamus, thalamus and limbic system
the efferent system of Autonomic NS
control of the efferent system
- medulla regulates the autonomic efferent system in spinal cord and vagus nerve
- hypothalamus is the master controller of homeostasis via pituitary, brainstem, and spinal cord
- visceral info from thalamus projects to limbic system (increase HR with anxiety)
- connect with somatosensory nociceptive afferents as in referred pain
- connect with somatic efferents as in muscle guarding
How is the CNS connected to the autonomic effectors
- preganglionic from CNS to ganglion
- post ganglionic connects ganglion with organ
what are the three systems within the Autonomic NS
- sympathetic NS
- parasympathetic NS
- enteric NS
comparision of sympathetic and parasympathetic NS
- sympathetic nervous system also known as the thoracolumbar or adrenergic system and postganglionic neurotransmitter = NE
- parasympathetic NS is known is cranosacral and postganglionic NT = AcH
function of the Sympathetic NS
- optimal blood supply to organs (orthostatic hypotension if this doesnt happen)
- respose to flight or fear
- maintain blood pressue with change of position
- regulation of body temperature (adrenal medulla releases epi.)
- blood flow regulation in skeletal muscules
Fight or flight response
- sweating
- hair cells
- pupil dilation
- vasoconstriction in skin and gut to increase blood flow to active muscules
- blood glucose levels increase
- bronchi and coronary vessels dilate
- BP/HR increase
- sympathetic firing decreases digestive system activity
Sympathetic NS efferent
preganglionic
- cell bodies of preganglionic neurons are in lateral horn of spinal cord T1-L2
- preganglionic neurons innervate adrenal medulla a specialized sympathetic ganglion
- secretes epinephrine and norepinephrine into blood stream
- preganglionic neurons to paravertebral ganglion where they synpase or go up or go down trunk to synpse in another ganglion
- ganglia are interconnected and form a trunk runnign beside vertebrae
Sympathetic NS efferent
postganglionic
- cell bodies of postganglionic neurons are in paravertebral ganglion
- postganglionic axon enters a peripheral nerve via a rami communicant
- then travels in a dorsal or ventral ramus to target organ
Sympathetic NS efferent
paravertebral ganglion
- cervical paravertebral ganglion that carry the preganglionic fibers from thoracolumbar area to head, face, and UE
- lower lumbar and sacral paravertebral ganglion descend from upper lumbar cord
Sympathetic NS efferent
Preganglionic axons to abdominal and pelvic organs
- pass through sympathetic ganglia without synpasing
- synpases is with an organ
- signals to GI tract: stop or slow peristalsis
- reduce gland secretion
- signals to seminal vesicles elicit ejaculation
Parasympathetic NS structure
- also known as cranial sacral
- arises from CNs and spinal levels S2-S4
- cholinergic system
- post ganglionic NT = acH
function of
Parasympathetic NS
- releases ACh onto end organs
- involved in more sedentary functions
- decrease pupil size, increase gastic secretion and peristalsis, slowing heart rate
- energe conservation and storage
enteric NS
- function is to serve the alimentary canal
- motility of the gut can function without the CNS, though if properly functioning is modulated by sympathetic and parasympathetic systems
- the enteric NS is entirely outside CNS inculding sensory nerves, interneurons and visceral motor neurons
ANS clinical disorders
Horners syndrome
- lesion affects the sympathetic pathway to the head
- sympathetic activity on one side of the head is decreased
- results in ipsilateral drooping of the upper eyelid, constriction of the pupil, skin, vasodilation with absence of sweating on the ipsilateral face and neck
ANS clinical disorders
autonomic dysfunction: spinal shock
- complete lesions above T6
- autonomic dysreflexia
- poor thermoregulation
- orthostatic hypotension
ANS clinical disorders
Autonomic dysfunction: peripheral region
- peripheral nerve severed = interruption of sympathetic efferents
- causes loss of vascular control, temperature regulation and sweating in region supplied by the peripheral nerve
- may lead to trophic changes in the skin
- postural orthostatic tachycardia syndrome (POTS)
ANS clinical disorders
Autonomic dysfunction: brainstem
- descendign control of heart rate, BP and respiration
- cranial nerve nuclei = interference of pupil constriction, tear/saliva production, regulation of thoracic/abdominal viscera
ANS clinical disorders
Autonomic dysfunction: cerebral region
hypothalamus damage disrupts homeostasis
Syncope
- brief loss of consciousness due to inadequate blood flow to the brain
- high emotion
- vasovagal attack
types of
syncope
- neural reflexive
- orthostatic hypotension
- cardiac arrhythmias
Syncope
neural reflexive
- neurocardiogenic/vasovagal-emotional distress
- situational-cough, sneeze, defecation, urination
- carotid sinus hypersensitivity
Syncope
orthostatic hypotension
- decrease of at least 20mmHg systolic BP or 10 mmHg during the first 3 minutes of standing
- gravity induced pooling of blood in the lower limbs, compromising venous return and cardiac output = decrease in arterial pressure
- spinal cord disorders, PD, peripheral neuropathy
tests of
autonomic function
- BP regulation with position changes
- sweat test: amout of salt in sweat
- vasomotor test
- valsava test: blow into closed tube with small hole