Neurophysiology Flashcards

1
Q

What are the 3 planes and corresponding axes of rotation of extraocular muscles?

A

-horizontal = vertical
-vertical = horizontal
-torsional = visual

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2
Q

what does Sherrington’s law of reciprocal innervation state?

A

For each eye, ‘antagonist’ muscles receive equal but opposite innervation

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3
Q

what does herring’s law of motor correspondence state?

A

For conjugate movements, ‘synergist’ muscles receive equal innervation (from CNS), i.e. certain muscles must co-contract (or co-relax) = “yoked” pairs Oculomotor Coordination

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4
Q

name the ipsilateral antagonists

A

-medial rectus
-lateral rectus
-superior rectus
-inferior rectus
-superior oblique
-inferior oblique

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5
Q

for each of the RE extraocular muscles name the contralateral synergists so state the yoked muscle pairs of the two eyes

A

-medial rectus = lateral rectus
-lateral rectus = medial rectus
-superior rectus = inferior oblique
-inferior rectus = superior oblique
-superior oblique = inferior rectus
-inferior oblique = superior rectus

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6
Q

why are there two sub divisions of the medial rectus?

A

because it is involved in both horizontal alignment and vergence

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7
Q

how are eye movements different to other muscle movements in the body?

A

there is a lack of a monosynaptic stretch reflex in extraocular muscles

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8
Q

give 3 devices that can measure eye movements and what are they all sampled at? What exactly can these measure?

A

-tobii pro spectrum
-eye link 1000+
-skalar

pupil boundary
pupil centre
gaze direction

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9
Q

why does the optic nerve have to be cushioned and protected?

A

as it moves alot when the eyes move

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10
Q

how do eye trackers work?

A

uses an image of the eye and by working out the center of the pupil and the geometry of the reflex, to find pupil boundary, centre and gaze direction, it can calculate how the eye is moving and where it’s looking.

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11
Q

what is the function of eye movements in general?

A

to provide a good, stable image

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12
Q

why do chickens move their bodies while keeping their heads completely still?

A

as they achieve stable image with their head instead of their eyes like us humans with foveal fixation

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13
Q

give an example in animals of how eye orientation in the head affects how a stable image is achieved

A

pigeons have eyes on the side of their head as every time they take a step forward, the image moves back so they bob their head to compensate

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14
Q

what are the two categories of eye movements and which eye movements fall in them?

A

-compensatory = stabilising
vestibulo-ocular reflex and optokinetic nystagmus

-targeting = fixation
saccades, smooth pursuit and vergence

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15
Q

what is gaze

A

where the fovea is looking independent of where the eyes are in terms of orientation or head movement

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16
Q

what is vestibulo-ocular reflex?

A

where your gaze remains unchanged even though the position of the eyes in the head changes due to fast, transient head movement

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17
Q

give an example that explains what vestibular nystagmus is

A

if you were to rotate 360 degrees, then you get a slow phase to compensate for the head movement and then a quick phase to reset the eyes because you have ran out of room and this maximises the amount of time you get a stable view of the world

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18
Q

what drives the vestibulo-ocular reflex?

A

a non visual stimulus - driven by afferent signal from inner ear canals

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19
Q

what is optokinetic nystagmus?

A

where gaze gets stabilised by generating an eye movement that’s in the same direction as the movement of the field - Occurs in all animals. When it reaches its max limit, it resets (saccades)

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20
Q

what is optokinetic nystagmus driven by?

A

retinal slip so has a visual stimulus

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21
Q

what are the two types of saccade?

A

-involuntary = anticompensatory reset during head rotation (or in OKN)
-voluntary = redirecting the foveal line of sight via reflex, visual (normal scanning) and memory (making saccadic movements in the dark)

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22
Q

what makes saccades different from other eye movements?

A

They are the only eye movement you can make to a non stimulus I.e. you don’t actually have to have something to look at for your eyes to make a saccade. This is the memory aspect of voluntary saccades

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23
Q

what kind of movement are saccades?

A

a ballistic movement

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24
Q

how long do saccades take to happen?

A

1/5 of a second

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25
Q

what are the two types of saccade

A

-Small saccade, short duration, lower frequency burst, occur at a lower velocity
-Large saccade, longer duration, higher frequency burst, occur at a higher velocity

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26
Q

what is smooth persuit?

A

-where you are following a small slow moving object as the visual stimulus by matching the velocity of the object as closely as possible
-only worries about how fast something is moving to track it not where it actually is
-Shows you can’t actually keep your eye on the ball so there’s a slow phase initially and then saccade and then slow phase as its going at high speeds

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27
Q

what is the latency of saccades?

A

200 ms latency

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28
Q

what is the latency of VOR compared to retinal processing

A

10ms latency compared to 70ms

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29
Q

what does visual masking for saccadic suppression need to work?

A

presence of stationary, highly contoured visual background before
and after saccade

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30
Q

what happens in the brain to allow for saccadic supression?

A

selective suppression of low spatial frequencies as the striate cortex is impaired during saccades

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31
Q

what is saccadic suppression?

A

No sense of a blurred image during saccades

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32
Q

what drives smooth persuit?

A

a visual stimulus that is a slow moving target

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33
Q

what is vergence?

A

where the eyes move away or towards each other. Generally is the slowest of the eye movements unless if it is in concert with saccades as needing to change the orientation means the saccade increases the speed of vergence

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34
Q

what effect does eye movement have on perception?

A

If your eye moves and the object is stationary vs is your eye is stationary and the object moves, the brain can detect whether it’s motion in the real world or not

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35
Q

what are the stimuli for vergence?

A

-blur = accommodative vergence (lens)
-diparity = fusional vergence (prism)

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36
Q

what inputs are required for an appropriate sense of visual motion?

A

-visual signals of retinal image movement
-head movement signals
-eye movement signals

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37
Q

what does neural control consist of?

A

gaze shifts and gaze holding

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38
Q

how do our eyes respond to a moving object?

A
  1. object in space moves
  2. retinal image moves
  3. head/ body moves
  4. eyes move
  5. appropriate perception of environmental motion requires multi-sensory input
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39
Q

what inputs are required for an appropriate sense of visual motion?

A

-signals of retinal image motion
-signals indicating head movement
-signals from eye movement

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40
Q

what other senses apart from vision are involved in self orientation?

A

-vestibular
-audition
-proprioception (motor and tactile)

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41
Q

what are MT and MST?

A

the middle temporal and middle superior temporal nuclei and these feed into the parietal lobe.

important in the visual pathways

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42
Q

what are the steps in the primary visual pathway and what is happening in parallel?

A

check page 9 of the op2501 term 2 google docs

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43
Q

what is proprioception?

A

having a sense of position of you body within the environment

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44
Q

what is efference copy?

A

the info sent to the brain of where the eyes are looking so the brain can determine where the object is in the world

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45
Q

what are the 4 gaze holding types of eye movement?

A

– Fixational
– Reflex (VOR, OKN)
– Smooth pursuit
– Vergence

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46
Q

what are the two gaze shifting types of eye movement?

A

-saccades
-fast phase of nystagmus

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47
Q

what are the three broad sections of the oculomotor system

A

-motor nuclei
-premotor circuitry systems (supranuclear gaze centers)
-common structures

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48
Q

what does the motor nucleus of the oculomotor system consist of?

A

CN 3, 4 and 6 and these control the EOM for eye movements connected via the MLF (a fibre tract not a nucleus)

49
Q

what do the premotor circuitry systems of the oculomotor system consist of?

A

In the pons you have the PPRF. This nucleus controls horizontal gaze shifts. This is near abducens (makes sense as that’s what drives eyes side to side)
In the midbrain you have the riMLF and this nucleus controls vertical gaze shifts. This is near oculomotor and trochlear (make sense as that’s what drives eyes up and down)
MRF which controls vergence and is in the midbrain

50
Q

what are the common structures of the oculomotor system?

A

Superior colliulus (tectum) in the midbrain brain (top of the brain stem)
Other cortical areas that project (frontal eye fields, supplementary eye fields and posterior parietal (LIP)

51
Q

what nucleus controls slow phase eye movements?

A

vestibular nucleus

52
Q

how can you move your eyes and hold gaze?

A

as it takes effort: the neural integrator calculates the position of the eyes in the orbit by taking into account the velocity of the eye movement

53
Q

what happens in horizontal gaze control?

A
  1. Signal pprf
  2. Left goes to left lateral rectus
  3. Interneurons cross the midline to go to the right medial rectus due to herrings law
  4. drives both eyes to the left

pprf goes to the left lateral rectus, right pprf goes to the right medial rectus so driving eyes to the left which means the right medial rectus drives eyes to the left
(hence left LR and right MR are yoked muscles)

54
Q

what are supranuclear, internuclear and infranuclear?

A

-premotor
-motor
-muscles

55
Q

check brainstem diagram in screenshots

56
Q

what eye movements does the neural integrator deal with?

A

-horizontal
-vertical
-torsional

57
Q

what eye movements do saccadic gaze generators do?

A

-horizontal
-vertical
-torsional

58
Q

what eye movements do persuit generators do?

A

horizontal and vertical

59
Q

in smooth persuit what side of the cortex does the persuit need to be stimulated to drive the eyes to the right?

A

the right side of the cortex

60
Q

what is the difference between projection for saccades compared to projection for persuit?

A

for saccades its crossed whereas for persuit its on the same side of the brain

61
Q

what happens in the brains for saccades to occur?

A

1Frontal eye field on the left
2.cross to the right pprf
3.Contract the right lateral rectus
4.interneuornes go across to left medial rectus and contract that

62
Q

what happens in the brain for smooth pursuit to occur?

A
  1. Projection is on same side
    2.Goes to pons nucleus DLPN
    3.Crosses to cerebellum and goes to medial vestibular nucleus
  2. Goes across back to abducens so you end up on the same side
63
Q

what is substantia nigra?

A

the first nucleus to generate in parkinson’s disease and so produces a change in eye movements that can be monitored and measured

64
Q

where is MLF and MRLF?

A

the midbrain

65
Q

where is PPRF?

66
Q

what areas of the brain are involved in vergence?

A

-cortex (MT, MST And LIP)
-MRF
-cerebellum
-oculomotor nuclei

67
Q

what law explains the fact that the same neuron that will activate one muscle will shut off when the opposite muscle is activated.

A

sherrington’s law

68
Q

what can cause a leaky neural integrator (so it does not work well)

A

can be a type of medication or cancer

69
Q

what does the neural integrator do?

A

resists the elastic forces on the globe that would normally drive the eye back to midline by using continued tonic innervation of the extraocular muscles

70
Q

what is pulse innervation?

A

phasic/ changing

where the eye movement requires a burst of energy to overcome inertia of the eyeball and signal is proportional to the size of the burst

71
Q

what is step innervation?

A

tonic/ steady

steady firing required to maintain the new eye position where firing rate is proportional to eye position

72
Q

how can you remember which extraocular muscles are yoked togther?

A

inferior oblique is yolked with the superior rectus, superior oblique is yolked with inferior rectus… superior, inferior, superior, inferior e.t.c.

73
Q

what neural integrators are in the cerebellum?

A

flocculus and paraflocculus

74
Q

what neural integrators control vertical and torsional movements?

A

interstitial nucleus of Cajal (INC)

75
Q

what neural integrators control horizontal movements?

A

nucleus prepositus hypoglossi (NPPH)
and medial vestibular nucleus (MVN)

76
Q

what does donder’s law suggest?

A

the amount of torsion in the eye is not determined by the direction of line of site and instead is determined by the degree of rotation of the eye in the horizontal and vertical axes

77
Q

what is listings law?

A

the 3d orientation of the eye and around its 3 axes

78
Q

what is the binocular visual field?

A

When you simultaneously allow both eyes to see the same stimulus, you get increased firing of those cells compared to if each eye was looking at the stimulus monocularly

79
Q

what does oblique penetration in V1 mean?

A

that you progress through ocular dominance groups 1-7 when using BV

80
Q

what does the V1 graph of primates suggest?

A

some cells will be more responsive to one eye than others

81
Q

how can two neural images provided by the visual cortex be combined?

A

through layering and averaging

82
Q

describe ocular dominance columns looking down on the visual cortex

A

-alternate in an ordered way and the spacing between each column (re le) is equal
-Each hypercolumn is a processing module that works together with other hypercolumns to process lots of visual info, not just colour and contrast.

83
Q

what is a hyper column? what does it do?

A

a chunk of cortex about 1mm square by 3mm thickness containing neurones with the same receptive field location but tuning to all possible selectivites and serves as a processing module for a particular area of the retina

84
Q

where are the blobs and interblobs?

A

In v1 you get spots (blobs) which process info about colour and between the blobs is inter blobs - 2 categories

85
Q

how can the thick and thin stripes in v2 be seen?

A

-Cytochrome oxidase staining allows you to see all of these stripes
-You can also see this using fMRI

86
Q

what does v2 contain?

A

Thick stripes, thin stripes and interstripes where:
-Parvo goes from thin to inter stripes, magno goes to thick stripes
-Thin stripes = colour hence V4

87
Q

what parts of vision does the temporal/ ventral (lower) pathway do?

A

-what pathway
-recognition
-shapes
-high acuity
-colour

88
Q

what parts of vision does the parietal/ dorsal (upper) pathway do?

A

motion and location

89
Q

where does most of the info in extrastriate area (V2) come from?

A

the striate cortex (v1)

90
Q

what info is thick stripes?

A

magno info - disparity, orientation and movement

91
Q

what kind of info is thin stripes?

A

parvocellular info - colour coded

92
Q

what kind of info is interstripes?

A

parvocellular info - orientation sensitive but no colour coding (unlike the parvocellular info in thin stripes)

92
Q

what does being able to adapt receptive fields of recognition cells allow you to do?

A

recognise the same people even after they age or change something about their face. Hence the cells are constantly creating new receptive field properties to recognise new things

92
Q

what is aphantasia?

A

inability to have a mental image of anything in your head - something you are born with and may be more common than we think

92
Q

give an example of a task someone with motion agnosia cannot do?

A

pour milk into a mug (they cannot identify moving objects)

93
Q

what is achromatopsia?

A

means the person can recognise the shape but has 0 colour perception - can reproduce the shapes but cannot reproduce colours

94
Q

what is apperceptive agnosia?

A

loss of form perception

95
Q

what is associative agnosiia?

A

loss of form recognition

96
Q

what is prosopagnosia?

A

inability to identify faces

97
Q

what are some examples of perception problems?

A

-Inability to recognise shapes but has the ability to reproduce them
-Inability to reproduce shapes
-Orientation perception difficulty - reflexive motor response is not damages though

98
Q

what can cause perception problems to arise?

A

CO poisioning

99
Q

what are the two types of simultanagnosia?

A

-dorsal = where the px cannot percieve more than one image amongst overlapping pictures
-ventral = px can recognise shapes and objects but have no associative perception

100
Q

what is visual hemifield neglect?

A

where one side of the parietal lobe has been damaged so the contralateral image cannot be seen, can be due to a stroke so people can recover over time - unilateral spatial neglect in a parietal patient

101
Q

what is simultanagnosia?

A

impaired object recognition in an agnosia patient

102
Q

what are the different cells in the different levels of the visual cortex?

A

-simple cells: respond best to stimuli at different angles/ orientations
-Complex cells respond to movement as well as orientation but are more responsive to movement so dont encode for absolute location but instead encode for texture
-In end stopped cell/ hyper complex cells the stimuli have to be at a particular orientation, be moving as well as be if a particular length

103
Q

what are the two types of simple cells?

A

-edge detectors = when the inhibitory and excitatory stimuli lie side by side
-bar detectors = where the excitatory/ inhibitory bar is in the middle depending on which of the two bar detectors it is

104
Q

how do simple cells work?

A

When the orientation is lined in the exact orientation of the detector then you get firing of the cell and if not then it does not fire

105
Q

where do each of the cells in the different levels of the visual cortex arise from?

A

-simple cells arise from the convergence of the center surround of several cells in the lgn like ganglion receptive fields
-complex cells arise from the convergence of input of simple cells
-hypercomplex cells arise form the convergence of input of complex cells

106
Q

how does resolution of the hypercolumn change throughout it?

A

Resolution of hypercolumn is lower in the peripheries of the visual cortex than in the center because there are less cells. So the density of cells determines how much foveal info is developed rather than the actual size of the hypercolumn as each hypercolumn is the same size. This is cortical magnification

107
Q

what is needed for a stimulus to trigger a simple cell?

A

the stimulus has to be the correct orientation and fall within a specific part of the visual field

108
Q

if an electrode penetrated the visual cortex obliquely, what will the receptive fields look like?

A

there is consistent drift in the position of the receptive field and the direction is dictated by the topographical map

109
Q

if an electrode penetrated the visual cortex vertically, what would the receptive fields look like?

A

the receptive fields would overlap but would vary in size as different cells within each hypercolumn will have different sized receptive fields e.g. cells in layers 3,5 and 6 will have larger receptive fields than those in 2 and 4 as they are all in the same location column (where the receptive fields pile on top of each other in pretty much the same place but have different sizes )

110
Q

how does the effect of a cortical shit on the receptive field position compare between the foveal region and peripheries of the primary visual cortex?

A
  • For the foveal region of the primary visual cortex, a cortical shift of 1-2 mm moves the receptive field position by only 0.1 visual degrees.
  • With increasing eccentricity, a cortical shift of 1-2 mm may move the receptive field position by several degrees.
111
Q

what is bandwidth?

A

Bandwidth is the ratio of spatial frequencies at which contrast sensitivity is halved so one octave of bandwidth is a doubling of spatial frequency.

112
Q

what is the bandwidth of LGN cells?

A

around 5 octaves

113
Q

how can you determine bandwidth from a spatial frequency graph?

A

go to the half, find out where it intersects the curve, look at the spatial frequency and see how many doublings (octaves) have occurred at each point. The number of octaves is the bandwidth

114
Q

what do the lobes of bar and edge detectors tell you?

A

smaller lobes have a higher/ optimal spatial frequency and more lobes mean a more narrow bandwidth so the more sharp the tuning is to spatial frequency

115
Q

what is the blob? how do spatial frequencies change closer and further from the blob?

A

one of the sites of targeting in the parvocellular system and is where colour vision is processed. Away from the blob are higher spatial frequencies and closer to the blog are lower spatial frequencies