Neuropharmacology Flashcards
Name a common SSRI
Fluoxetine
Name the 3 classes of antidepressants
Tricyclics
SSRIs
SNRIs
Bioavailability
Fraction of drug absorbed into systemic circulation
What route gives 100% bioavailability?
IV
Volume if distribution calculation
= total amount of drug /
conc in plasma
Why part if the brain is outside the BBB. What drug can act in it as it’s too big to cross the BBB?
Pineal gland
Melatonin
CL =
Vd ❌ kel
What substance involves zero order elimination?
Alcohol
Through what are drugs excreted?
Kidneys Lungs Bile Sweat Milk Saliva
Is lithium metabolised in the body?
No. Relies entirely on renal clearance
What can affect the renal clearance of lithium?
Dehydration Alcohol Non sodium sparing dietetics Polyuria Renal insufficiency
Does lithium have a wide or narrow therapeutic window?
Narrow
When do antidepressants kick in fully?
6-8 weeks
Tolerance
Desensitisation of target receptors after repeated administration
Sensitivity if receptors
Usually result of
Where is NA made?
Locus coeruleus
Where is serotonin made?
Raphe nuclei?
Where is dopamine made?
Substantial nigra
Psychosis
An altered way of perceiving the world
Loosing touch with reality
Name the 3 dopamine tracts
Nigrostriatal
Mesocortical & mesolimbic
Tuberounfundibular
Which tract controls prolactin release?
Tuberounfundubular
What’s the precursor if serotonin?
Tryptophan
Dopamine precursor?
Tyrosine
NA precursor?
Dopamine
