Depression & Us Of Antidepressents Flashcards
Life time risk of depression
10-20%
Women 2 x higher than men
What is the annual prevalence of depression in western countries?
3-10%
What part of the brain an shrink I depression?
Hypocampus
Due to ⬆️ cortisone
Why do people with depression live on average 10 years less than other patients?
Suicide
Higher CV risk
Higher cancer risk
5HT
5 hydroxy triptonine
Why are drugs called ‘tricyclics’
They contain 3 aromatic rings
Name some common SSRIs
Prozac (fluoxetine)
Citalopram
Paroxatine
Sertraline
Side effects if SSRIs
Restlessness
Nausea
Diohrheao
Vomiting
Side effects of tricyclics
Nausea Sedation Postural hypotension Dry mouth Constipation
Dangerous in OD
What do MAOIs break down?
Serotonin
NA
Dopamine
So block MAOIs: treats depression
Side effects of MAOIs
Special diet- risks!
Hypotension
Constipation
Drowsiness
Why do GPs usually use to treat Depression?
SSRIS
What is the most effective treatment if sever depression that doesn’t respond to drugs?
ECT
