Neuropath: Oncology Flashcards

1
Q

AFP stains for

A

embryonal carcinoma, endodermal sinus tumor

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2
Q

chromogranin

A

pituitary adenoma

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3
Q

Common leukocyte antigen

A

lymphoma, germinoma

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4
Q

Cytokeratin

A

craniopharyngioma, chordoma

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5
Q

Desmin

A

rhabdosarcoma, teratoma

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6
Q

Vimentin, epithelial membrane antigen

A

meningioma

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7
Q

GFAP

A

astrocytomas

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8
Q

HMB 45 s100

A

melanoma

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9
Q

immunoglobulin K and L chains

A

lymphoma

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10
Q

neurofilament and synaptophysin

A

ganglioma, PNET

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11
Q

S100

A

schwannoma, RCC, chordoma , PNET, glioma, neurofibroma

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12
Q

transthyretin

A

choroid plexus tumors

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13
Q

two phases of cell replication that are susceptible to radiation

A

G1 and M phases

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14
Q

antibody associated with cerebellar degeneration and breast cancer

A

Anti-YO

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15
Q

sensory neuropathy and small cell (oat cell)

A

anti-hu

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16
Q

opsoclonus and breast cancer

A

anti-ri

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17
Q

Rosenthal Fibers (hair-like)

A

juvenile pilocytic astrocytoma

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18
Q

pseudopallisading necrosis

A

GBM

19
Q

fried egg cells with chicken wire arrangement

A

oligodendroglioma

20
Q

true rosettes and pseudorosettes

A

epndymoma

21
Q

halo like fried egg but stains with synaptophysin and neuron specific enolase

A

central neurocytoma

22
Q

monosomy seen in meningiomas

A

22

23
Q

HomerWright rosette (central fibrillar material ringerd by cell nuclei ) seen in

A

medulloblastoma, pineocytoma and neuroblastoma

24
Q

abundant thin walled vascular channels interspersed with enlarged vacuolated stromal cells

A

hemangioblastoma

25
Q

Adamantinomatous pattern and wet keratin

A

craniopharyngiomas

26
Q

most common pineal tumor

A

germinoma

27
Q

large polygonal cells with large nuclei and t-cell infiltrates

A

germinoma

28
Q

monotonous polygonal cells

A

pituitary adenomas

29
Q

physaliphorus or bubble bearing cells in mucoid rich stroma

A

Chordoma

30
Q

NF1 vs NF2

A

NF1 optic glioma, Lisch nodules of iris and chrom17 neurofibromin

NF2 is 22/merlin/no systemic disease/shwannoma

31
Q

IDH1

A

low grade gliomas

32
Q

marker for glial intermediate filaments

A

GFAP (astrocytoma)

33
Q

marker for epithelial intermediate filaments

A

cytokeratin (think carcinoma generally)

34
Q

marker for T cells

A

CD3

35
Q

marker for B cells

A

CD 20

36
Q

marker for melanocytic cells

A

Melan-A HMB-45

37
Q

marker for lymphocytes

A

CD45

38
Q

chrom. deletion assocaited with progression in anaplastic astrocytoma and GBM

A

p16

39
Q

better prognosis in oligodendroglioma

A

codeltion of 1p19q

40
Q

chroid plexus papillomas usually arise from which ventricle ?

A

lateral.

41
Q

mutliple mets think

A

melanoma and small cell

42
Q

most common chrom defect in medulloblastoma and poor prognositc oncogene

A

chrom 17 and N-myc

43
Q

primary CNS lymphoma is usually what kind ?

A

diffuse B cell