Neuropath: Neuro Devo and General Path Flashcards
Three types of edema and pathophys
Vasogenic - Extracellular BBB
Cytotoxic- hypoxia - failure of NaK ATPase pump
Interstitial - hydrocephalus
Nissl stain
neuon cell bodies
H&E
general path exam
silver stain
axons and dendrites
Lipofuscin
accumulates with aging
Neuromelanin
accumulates neurons (SN and LC)
lethal neuronal injury
eosinophilic (red is dead) ferrugination.
Two viruses intranuclear inclusion bodies
HSV 1, CMV
Two viruses that can be intracytoplasmic and/or intranuclear
Measles (SSPE) and CMV
All inclusion bodies in degnerativ/metabolic diseases are
intracytoplasmia
Hamartoma definition
disorganized cells in the right location
Choristoma def
organized cells in the wrong location
Rosenthal fibers (eosinophilic masses) seen in three things
pilocytic astrocytoma, astrocytosis, Alexander’s disease
callosal agenesis, female, ocular abnormalties and infantile spasms
Aicardi’s
Chiari I not associated with _____
brain abnormalities
Chiari 1 herniation of tonsils and chiari II herniation of
tonsils / vermis
Chiari III hindbrain herniates into
encephalocele
chiari IV is cerebellar
hypoplasi
Dandy-Walker malformation
posterior fossa continuous with fourth ventricle
most common craniosynostosis
saggital
Two most common craniofacial syndroms and main differences.
Crouzon’s #1 increased risk of hydrocephalus
Apert’s # 2 includes severe MRDD and GI/GU/Cardiac
Chromsomal disorder with Alz, congenital heart disease and hypotelorism
trisomy 21
Chromosomal disorder with hypertelorism (increased distance between eyes
5 p deletion Cri du chat
Most frequent cause of hereditary MRDD
Fragile X
cephalohematoma does not ____
cross suture lines
kernicterus affects mainly the ____
globus pallidus
