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MICR2120 Cell Biology of Disease > Neuronal Cells > Flashcards

Neuronal Cells Flashcards

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1
Q

What are nissle bodies?

A

rER and free ribosomes for protein synthesis. Proteins then replace ceuronal cellular components for growth and repair of damaged axons in the PNS

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2
Q

What are unipolar neurones?

A

Cell body in the middle of an axon

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3
Q

What is resting potential?

A

-40 to -90mv typically -70

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4
Q

What is the threshold for influx of Na2+?

A

-55

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5
Q

What is the depolarising current

A

+30mv

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6
Q

What causes fusion of synaptic vesicles to the plasma membrane?

A

Ca2+

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7
Q

What are the NTs which cause channels to open?

A

Ionotropic

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8
Q

What are the NTs which result in a second messenger system

A

metabotropic

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9
Q

What are the treatments for multiple sclerosis?

A 
B-inteferons
target inflammation (alemtuzumab binds CD52 on lymphocytes and
Glatiramer acetate (peptides that correspond to sequences in myelin)
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10
Q

What is tetanus?

A

Infection via wound contamination, affects inhibitory neurones, cause stiffness and spasms in jaw muscles

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11
Q

What is botulism?

A

Food poisoning causing difficulty swallowing and speaking

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12
Q

How do tetanus and botulinum affect the body?

A

Cleave SNAREs at specific sites preventing exocytosis of vesicles

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13
Q

What are neurodegenerative disorders characterised by?

A

Gradual loss of neurons

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14
Q

What is Alzheimer’s

A

Intracellular neurofibrillary tangles and extracellular amyloid plaques

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15
Q

What is Parkinson’s disease

A

Lewy bodies

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16
Q

What is Huntington’s

A

Intracellular inclusion and cytoplasmic inclusions

17
Q

What causes the increase in plaques in Alzheimer’s

A

A-beta-peptide cleaves amyloid precursor

18
Q

Whay is acetylcholine used to treat Alzheimer’s

A

Cholinesterase inhibitors, prevent the breakdown of tetracycline which is involved in memory and learning

19
Q

What are NMDA antagonists?

A

Excessive activation of NMDA receptors may underlie the degeneration of cholinergic cells

MICR2120 Cell Biology of Disease (14 decks)

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