Neurology - Level 1 Flashcards
Definition of stroke?
o Syndrome of rapid onset of cerebral deficit lasting >24 hours with no apparent cause except vascular
o Complete – deficit becomes maximal <6 hours
o Stroke in evolution – progression during first 24 hours
Definition of ischaemic stroke?
Due to ischaemia and death of tissue following vascular occlusion or stenosis
Definition of haemorrhagic stroke?
Due to collection of blood from rupture of blood vessel within the brain (intercerebral) or between brain and arachnoid tissues (subarachnoid)
Definition of TIA?
o Sudden focal deficit lasting <24 hours with complete recovery and no evidence of acute infarction
Epidemiology of stroke?
2nd commonest cause of death worldwide 7% of deaths in UK Rates higher in Asians and Africans Incidence 1 in 1000 Men > Women
Risk factors of stroke?
- Hypertension, AF, Valve disease
- DM, PCV, Syphilis
- Smoking, Obesity, Alcohol, High cholesterol, clotting factors, OCP
- Hx of TIA
Aetiology of stroke?
- Ischaemic (85%) – embolism/thrombosis/artherosclerosis
- Haemorrhagic (15%) – intracranial, SAH
- Rare – Venous thrombosis, sudden BP drop, lesion, carotid artery dissection
- TIA – microembolism from atherosclerotic plaques or mural thrombi
Symptoms of TIA - carotid artery symptoms?
- Sudden onset of focal deficit usually lasting 5-15 minutes
o Hemiparesis – unilateral weakness to one side of body
o Hemiplagia – flaccid and then spastic
o Aphasia – speech problems
o Ataxia, vertigo, syncope
o Amaurosis Fugax – sudden transient loss of vision in one eye
o Hemianopia
Symptoms of TIA - vertebrobasilar symptoms?
o Diplopia o Vertigo o Vomiting o Choking and dysarthria o Ataxia o Hemisensory loss o Visual loss
Symptoms of stroke - cerebral infarction?
- Sudden onset focal deficit ongoing or persisted for >24 hours and cannot be explained by another condition
o Symptoms of TIA, Sensory loss, hemiplegia (flaccid and then spastic), dysphagia, hemianopia
Symptoms of stroke - brainstem infarction?
o Lateral medullary syndrome – vertigo, Horner’s, facial numbness, ataxia, nystagmus
o Locked in syndrome
Symptoms of stroke - lacunar haemorrhage?
o Pure motor, sensory, ataxic hemiparesis, cognition intact
Symptoms of stroke - cerebral haemorrhage?
Sudden LOC, severe headache and meningism
Oxford Bamford Stroke Classification - Total Anterior Circulation Stroke (TACS)?
o Large stroke – both the middle and anterior cerebral arteries
o All 3 of following:
Unilateral weakness (and/or sensory deficit) of face, arm and leg
Homonymous hemianopia
Higher cerebral dysfunction (dysphasia, visuospatial disorder)
Oxford Bamford Stroke Classification - Partial Anterior Circulation Stroke (PACS)?`
o Less severe than TACS, part of anterior circulation compromised
o 2 of the following:
Unilateral weakness (and/or sensory deficit) of face, arm and leg
Homonymous hemianopia
Higher cerebral dysfunction (dysphasia, visuospatial disorder)
Oxford Bamford Stroke Classification - Posterior Circulation Stroke (POCS)?
o Damage to area supplied by posterior circulation (cerebellum and brainstem)
o 1 of the following:
Cranial nerve palsy and contralateral motor/sensory deficit
Bilateral motor/sensory deficit
Conjugate eye movement disorder (horizontal gaze palsy)
Cerebellar dysfunction (vertigo, nystagmus, ataxia)
Isolated homonymous hemianopia
Oxford Bamford Stroke Classification - Lacunar Syndrome (LACS)?
o Subcortical stroke secondary to small vessel disease (no loss of higher cerebral function)
o 1 of the following: Pure sensory stroke Pure motor stroke Sensori-motor stroke Ataxic hemiparesis
Initial Assessment in A&E of stroke?
FAST tool/Rossier Tool --- Stroke unlikely if score 0 or less Facial Weakness (asymmetrical) (1) Arm Weakness (asymmetrical) (1) Leg weakness (asymmetrical) (1) Speech disturbance (1) Visual field defect (1) Loss of consciousness or syncope (-1) Seizure (-1) ABCDE assessment – protect airway Vital signs – BP, pulse, O2 sats, HR, temp Blood glucose ECG Neurological assessment (fundoscopy)
Management of TIA - initial assessment?
- ABCD2 (not used anymore) o Age >60 o BP >140/90 o Clinical weakness (2)/speech problem (1) o Duration >1hr (2)/<1hr (1) o Diabetes (1)
Management of TIA - initial management?
o Aspirin 300mg immediately (with PPI)
o Refer for urgent (within 24 hours of symptoms) assessment with specialist
Management of TIA - brain imaging?
CT
Do not offer CT scan unless suspicion of alternative diagnosis that CT could detect
MRI
After specialist assessment in TIA clinic, consider to determine territory of ischaemia or haemorrhage – perform on same day
Management of TIA - further management?
Carotid imaging and carotid endarterectomy
Extent measured using NASCET or ECST
Surgery when symptomatic & NASCET >50% or ECST >70% stenosed
Stenting alternative if patient unable to have endarterectomy
Management of TIA - secondary prevention?
Clopidogrel 75mg daily
Dipyridamole MR + aspirin
• Dipyridamole MR alone if aspirin contraindicated/not tolerated
Management of stroke - initial assessment?
o FAST tool/Rossier Tool Stroke unlikely if score 0 or less • Facial Weakness (asymmetrical) (1) • Arm Weakness (asymmetrical) (1) • Leg weakness (asymmetrical) (1) • Speech disturbance (1) • Visual field defect (1) • Loss of consciousness or syncope (-1) • Seizure (-1)
Management of stroke - initial management?
o ABCDE assessment – protect airway
o Vital signs – BP, pulse, O2 sats, HR, temp
o Oxygen (only if O2 <95%)
Management of stroke - initial investigations?
o Blood glucose —- Maintain at 4-11mmol/l with IV glucose and insulin in T1DM
o ECG
o Neurological assessment (fundoscopy)
o NBM if choking risk – NG tube within 24 hours, gastrostomy if needed
o Blood tests —- ESR, FBC, glucose, U&Es
Management of stroke - imaging?
CT scan
Management of stroke - when to perform CT within 1 hour?
If indications for thrombolysis (<4.5 hours)
On anticoagulant or Bleeding tendency
GCS<13
Progressing or fluctuating symptoms
Papilledema, Neck stiffness, Severe headache
Management of stroke - when to perform CT within 24 hours?
If no indications for immediate brain scanning
Management of stroke - further imaging?
o If thrombectomy indicated – CT contrast angiography & add on CT perfusion imaging (or MR equivalent) if indicated beyond 6 hours of symptom onset
Management of stroke - management of confirmed ischaemic stroke?
o Aspirin 300mg (orally or rectal/enteral if dysphagia) once haemorrhagic excluded
Add PPI if previous dyspepsia
Continue aspirin 300mg daily until 2 weeks after stroke
Then start definitive long-term antithrombotic treatment
Management of ischaemic stroke - thrombolysis - when is it indicated and how? Post-thrombolysis management?
<4.5 hours onset and haemorrhage been excluded on CT
IV recombinant tissue plasminogen activator (alteplase 0.9mg/kg over 1h)
CT 24-hour post lysis to identify bleeds
Management of ischaemic stroke - thrombectomy - when is it done and why?
ASAP and within 6 hours of symptoms, with IV thrombolysis if:
• Acute ischaemia stroke and confirmed occlusion of proximal anterior circulation on CTA or MRA
ASAP in people who were well 6-24 hours previously
• Acute ischaemia stroke and confirmed occlusion of proximal anterior circulation on CTA or MRA
• AND salvagable on CT/MRI with limited core infarct
Pre Stroke mRS <3 and NIHSS >5
Management of ischaemic stroke - cerebral sinus thrombosis?
• Full-dose LMWH and then warfarin (INR2-3)
Management of ischaemic stroke - ischaemic stroke with AF?
Aspirin 300mg for first 2 weeks before anticoagulation treatment
Management of ischaemic stroke - haemorrhagic stroke with DVT/PE?
• Treat with anticoagulation or caval filter to prevent further pulmonary emboli
Management of haemorrhagic stroke - initial management?
Refer to neurosurgery
Managing hydrocephalus
Previously fit people – consider surgical intervention
Management of haemorrhagic stroke - medical treatment initially - when?
Small deep haemorrhages
Lobar haemorrhage without either hydrocephalus or rapid neurological deterioration
Large haemorrhage and significant comorbidities
GCS <8, unless due to hydrocephalus
Posterior fossa haemorrrhage
Management of haemorrhagic stroke - reversing anticoagulation?
If receiving warfarin (and have elevated INR) – use IV vitamin K and prothrombin complex concentrate
Management of haemorrhagic stroke - blood pressure control?
Offer to all, without exclusions, if present within 6 hours of symptoms and systolic blood pressure between 150-220:
• Aim for 130-140 within 1 hour of starting treatment and maintain for at least 7 days
• Use IV labetalol 5mg bolus for rapid control, GTN infusion used for long-term hospital control until titrated onto oral medications
Management of haemorrhagic stroke - When not to offer BP control?
- Structural cause (tumour, arteriovenous malformation, aneurysm)
- GCS<6
- Having early neurosurgery to evacuate haematoma
- Massive haematoma with poor prognosis
Management of stroke in specialist stroke unit?
Admit everyone with stroke directly to specialist acute stroke unit after initial assessment
Swallow Function (specialist assessment within 24 hours and not >72 hours)
NG tube and fed within 24 hours unless had thrombolysis
Nasal bridle tube or gastrostomy if unable to tolerate NG tube
Refer to dietician
Amend oral medications
Early Mobilisation
Help patients sit out of bed, walk as soon as able
Statin Treatment
Do not start in acute stroke but continue if already on statin
When to perform decompressive hemicranectomy in stroke?
If middle cerebral infarction within 48 hours who:
• >15 on NIHSS
• Decreased level of consciousness, score of 1 or more on item 1a of NIHSS
• Signs on CT of infarct in >50% MCA territory
When to image carotid arteries in stroke?
Carotid imaging and carotid endarterectomy
• Extent measured using NASCET or ECST
• Surgery when symptomatic & NASCET >50% or ECST >70% stenosed
• Stenting alternative if patient unable to have endarterectomy
Rehabilitation teams involved in stroke?
o Inpatient stroke rehabilitation service
o Offer training in care for family members, carers
o May need SALT, OT, orthoptics, physiotherapy, fitness training
AF stroke prevention following acute stroke?
• Aspirin 300mg for 2 weeks, then restart anticoagulation (warfarin/DOAC) and stop aspirin
Secondary prevention of ischaemic stroke or TIA?
Control risk factors – HTN, DM, HF, BP (<130/80)
Atorvastatin 80mg daily (started 48h after ischaemic stroke)
Clopidogrel 75mg daily (dipyridamole 200mg + aspirin 75mg if clopidogrel contraindicated or not tolerated)
Follow up after acute stroke?
o Follow up at specialist clinic in 6 weeks
o 6-month primary care and then annually with specialist
General advice given to stoke patients?
o No LMWH for 2 months o Inform DVLA – no driving for 1 month o Assessment to return to work and may need support o Encourage physical activity o Stop smoking o Keep low salt intake o Reduce alcohol o Physio/OT assessments