Level 1 - Respiratory Flashcards
What is asthma?
- Chronic airway inflammation, bronchial hyper-reactivity and reversible airway obstruction
Pathology of asthma?
- mix of genetic predisposition, atopy and environmental triggers that cause:
o Bronchial inflammation
o Infiltration of neutrophils, eosinophils, mast cells, lymphocytes
o Bronchial hypersensitivity
o Airway narrowing
o Thicker, excessive mucous production
o. Reversibility
Epidemiology of asthma?
- Commonest childhood chronic illness
- 15-20% of children
- Males>females
Risk factors for asthma?
- Atopy (40% have FHx)
- Smoking
- Low birth weight/Premature birth
Triggers for asthma exacerbation?
- Allergens (house dust mite, pollen, pets, feathers, fur)
- Exercise
- Viruses
- Cold
- Smoke/Pollution
Symptoms of asthma?
- Cough o Recurrent, dry cough o Worse at night and with exercise (diurnal variation) - Wheeze o Expiratory noise due to airway narrowing o Prolonged expiration o Responds to bronchodilators - Shortness of breath o Limiting exercise, daily life - Stunted growth
Signs of asthma? When is it worse?
Signs (usually normal between exacerbations)
- Barrel-shaped chest
- Accessory muscle use
- Hyperinflated chest
- Harrisons sulcus
What symptoms are there in an acute asthma attack? How is it classified?
- Acute SOB, cough, wheeze, work of breathing
- Severity
o Mild – breathlessness, PEFR >50% of expected
o Severe – cannot complete sentances, RR >25, pulse >130bpm, PEFR <50% of expected
o Life-Threatening – ACHEST3392
DDx of asthma?
Bronchiolitis Pneumonia/TB Inhaled foreign body Croup Cystic Fibrosis
Investigations for children under 5?
- Treat symptoms based on observation and clinical judgement
- Review child regularly
- If still have symptoms at 5 years, carry out objective testing
When to perform investigations for asthma in children 5-16 years?
- Treat immediately if they are acutely unwell
- Perform objective tests for asthma if the equipment is available and testing will not compromise treatment of the acute episode
Give the objective investigations in asthma? Give the positive result values?
o Spirometry FEV1/FVC<70% of predicted o BDR test FEV1 improvement of >12% if positive Diagnosed if both spirometry and BDR positive o FeNO test If uncertain and negative spirometry and BDR 35ppb or more is positive test Refer if negative o PEFR variability 2-4 weeks If normal spirometry OR obstructive spirometry, negative BDR, positive FeNO >20% variability is positive
What happens if child unable to perform objective tests in asthma?
- Treat based on observation and clinical judgement
- Try doing the tests again every 6 to 12 months
What other investigations may be needed to rule out other DDx in asthma?
Chest X-Ray – if exclusion of pneumothorax is needed
Allergy tests – skin prick test
Sputum culture
General measures in asthma management?
Reduce exposure to triggers
Monitor disease
- Symptom and PEFR diary
- After starting or adjusting medicines for asthma, review the response to treatment in 4 to 8 weeks
Educate the family about good inhaler technique
When will you move up asthma ladder in chronic treatment?
3x SABA per week, woken
3 month usually
Step 1 in asthma treatment in children all ages?
- Inhaled short-acting B2 agonist (salbutamol, terbutaline, ipratropium bromide (infants/children))
Step 2 in asthma treatment in children under 5?
Add LTRA
Step 3 in asthma treatment in children under 5?
• Low dose ICS – 8-week trial
- If symptoms resolved then reoccurred within 4 weeks of stopping ICS – restart on low-dose ICS
- If symptoms resolved but reoccurred beyond 4 weeks of stopping ICS, repeat low-dose ICS
Step 4 in asthma treatment in children under 5?
•Refer to respiratory physician
Step 2 in asthma treatment in children aged 5-16?
• Add inhaled paediatric low dose ICS
Step 3 in asthma treatment in children aged 5-16?
• Add on LABA
Review 4-8 weeks
If no response, stop LABA and start LTRA
Step 4 in asthma treatment in children aged 5-16?
• Add LTRA
Step 5 in asthma treatment in children aged 5-16?
• Increase dose of ICS to paediatric moderate dose
Referral to paediatrician
Step 6 in asthma treatment in children aged 5-16?
Increase ICS dose to high dose
Trial of theophylline
Refer to paediatrician
What inhalers should be used in children and what else should be prescribed?
- <5 years, use pMDI and spacer device
• If not tolerated, DPI in 3-5 years or nebuliser - 5-16 years, pMDI and spacer device
Management of mild & severe acute exacerbation in asthma?
Mild - 10 puffs of SABA (given when no oxygen requirement), prednisolone 1-2mg/kg PO 3 days, give 10 puffs of inhalers when needed and space out
Severe
- 1. High flow Oxygen (100%, 15L)
- Salbutamol nebulised
o 10 puffs of SABA if not life-threatening
o 5mg O2-nebulised in 4mL saline (2.5mg if <5 years)
o Continuously then every 30 mins and space out
- Salbutamol nebulised
- Hydrocortisone IV/Prednisolone oral
o Hydrocortisone – 100mg IV
o Prednisolone – 1-2mg/kg to max 40mg (50mg >12 years)
- Hydrocortisone IV/Prednisolone oral
- Ipratropium bromide nebulised
o Can do same time as salbutamol
o 0.25mg in 4mL saline
o Every 20-30 mins for 1st 2 hours then everyW 8 hours if needed
- Ipratropium bromide nebulised
- Magnesium sulphate IV one-off dose
o 40mg/kg over 20 mins (<2g)
- Magnesium sulphate IV one-off dose
- Theophylline (Aminophylline IV)
o 5mg/kg over 20 mins
o Give ondansetron as causes vomiting
- Theophylline (Aminophylline IV)
- Before discharge
o Need PEFR >75%, good inhaler technique
o Wheeze plan
o Inhaled steroids and oral prednisolone (3 days)
Follow-up GP in 1 week and clinic in 4 weeks
What complications dose excessive steroid usage cause children in asthma?
Excessive steroid use
- Impaired growth, adrenal suppression, oral candidiasis
Pathology of bronchiolitis?
- RSV (respiratory syncytial virus) invades the nasopharyngeal epithelium and spreads to the lower airways
- Increased mucus production, desquamation and then bronchial obstruction
- Net effect = pulmonary hyperinflation and bronchiolar atelectasis (one or more areas of your lungs collapse or don’t inflate properly)
Typical time course of bronchiolitis?
- Typically, a 9-day illness
o 3 days prodrome- cold and harsh cough
o 3 days fever + high pitched wheeze + breathless
o 3 days: recovery
Epidemiology of bronchiolitis?
- COMMONEST serious respiratory infection of infancy: 2-3% of all infants are admitted to hospital with the disease each year during winter.
- Usually in infants <2 years old, affects everyone by the age of 2
- 90% are aged 1-9months
Risk factors for bronchiolitis?
o CHD (congenital heart defect) o Chronic lung disease e.g. CF o Prematurity o Immunodeficiency Passive smoking
Causative agents in bronchiolitis?
- RSV (respiratory syncytial virus, single-stranded RNA) - 80%
- Others include parainfluenza, influenza, adenovirus, rhinovirus, metapneumovirus and mycoplasma pneumonia
- Dual infection with RSV + metapneumovirus severe bronchiolitis
Symptoms of bronchiolitis?
- Preceded by coryzal symptoms
- Dry cough respiratory distress (worsening SOB) + wheeze
- Low Fever
- Feeding difficulty
- Episodes of apnoea
- Rarely encephalopathy with seizures due to hyponatraemia
Signs of bronchiolitis?
- Cyanosis or pallor
- Sharp, Dry cough
- Tachypnoea + tachycardia
- Subcostal and intercostal recession
- Chest hyperinflation prominent sternum + liver displaced downwards
- Pauses in breathing or apnoea
- On auscultation:
o Wide spread wheeze
o Prolonged expiration
o Fine end-inspiratory crackles
Investigations in bronchiolitis?
- Vital Signs to measure level of respiratory distress
- Nasal/Throat Swabs
Others: - Capillary blood gas only done in severe infections
Throat swabs - CXR only needed in atypical cases to rule out pneumothorax/lobar collapse
o Will show hyperinflation, widespread consolidation
Management of bronchiolitis?
Most infants treated at home
Hospital when:
- Feeding poorly, lethargy, sats <94%, tachypnoea
Hospital treatment:
- Humidified O2 via high flow nasal cannula
o SpO2 >92%
- If tachypnoea, minimise oral feed - use NGT feeds
- Mechanical ventilation if severe
o CPAP or via high flow nasal cannula - Not routinely given but nebulised salbutamol to ease wheeze
Prevention of bronchiolitis?
Mortality increase in which groups (given preventative measures)?
- Palivizumab (monoclonal antibody to RSV) given monthly by IM injection for 6 months in high risk pre-term infants
Congenital heart, preterm infants, immunodeficiency
What does croup stand for?
Laryngotracheobronchitis
Name the 3 common conditions in tracheal inflammation?
Viral croup
Spasmodic croup
Acute epiglottitis