CYP450 DRUGS

Question 1

What effect do CYP450 inducers have?

Answer 1

Induce enzymes to reduce level of drugs metabolised by CYP

Reduce effect of metabolised medication

Question 2

What effect do CYP450 inhibitors have?

Answer 2

Inhibit enzymes to increase level of drugs metabolised by CYP
Increase effect of metabolised medication

Question 3

Drugs metabolised by CYP450 enzymes?

Answer 3

C3OWP2AT2S2

• Ciclosporin, citalopram, carbamazepine
• OCP
• Warfarin
• Phenytoin, protease inhibitors
• Acetylcholinesterase inhibitors (donepezil)
• Theophylline, tacrolimus
• Statin, steroids

Question 4

Inducers of CYP450 enzymes?

Answer 4

CRAP BS GPS

• Carbamazepine
• Rifampicin
• Alcohol
• Phenytoin
• Barbiturates
• St John’s Wort
• Griseofulvin
• Phenobarbital
• Sulfonylureas

Question 5

Inhibitors of CYP450 enzymes?

Answer 5

SICKCAGES.COM.FAQ

• Sodium Valproate
• Isoniazid
• Cimetidine
• Ketoconazole
• Chloramphenicol
• Alcohol
• Grapefruit Juice
• Erythromycin
• Sulphonamides
• .
• Ciprofloxacin
• Omeprazole
• Metronidazole
• .
• Fluconazole
• Amiodarone
• Quinidine