neuroimaging Flashcards
MRI
scan and create images of brain structure
beneficial to detect brain abnormalities
test structural differences in brain
how does an MRI work
large magnets
take slices to construct a 3D model
- coronal plane
- horizontal plane
- sagittal place
lots of images taken in rapid succession whilst people do things
enables us to look at brain function
how does an fMRI work?
determines activity by detecting changes in the magnetic response of haemoglobin
iron molecule found in haemoglobin gives blood magnetic properties
when magnet presented to brain, haemoglobin molecules line up
haemoglobin lose oxygen in areas of high brain activity
makes haemoglobin more magnetic and therefore molecules respond stronger to magnetic field
measured changes are BOLD
blood oxygen level dependant
the haemodynamic response function
cant measure neuron spiking
only measure th energy craving after the activity
indirect measure of neuron activity
measures metabolic consequences 4-6 seconds after
PET scan
uses same machine as an fMRI
radioactive crater substance injection to make blood flow more visible
more direct measure of blood flow compared to magnetic field differences
subtraction method
used to see specific brain functions
keep entire environment the same except what is being observed
can be compared to show difference
measure 2 variations of same mental function
only differ in one aspect
observed difference must be due to variation
PET vs fMRI
PET has better:
signal to noise ratio
higher sensitivity to blood flow
movement less problematic
fMRI better:
resolution
clearer image
more accurate - better to detect locations
quicker than PET
but prone to movement artifacts (noise)
diffusion tensor imaging DTI
makes nerve fibre tracts (physical connections between neuron tracts) visible
can be used to build realistic models of neural structures
explains how far away areas of the brain can work together to complete a function
central principle of cognition
most of our experience is multidimensional
specific functions are both localised and distributed across different areas
functional connectivity
when neurons work in synchronisation during certain tasks
neurons do not need to be physically connected to work together and form neural networks
empirical methods
used to experimental confirmation, exploration and debunking
behaviour
self report
- questionnaires and interviews
observable
- reaction times an pupil dilations