Neurogenetics of common psychological disorders

Question 1

What is the occurrence rate of major depressive disorder?

Answer 1

8-12% in most countries

Question 2

What is the typical age of onset for major depressive disorder?

Answer 2

Initial onset is typically 20-30, with a later peak 30-40

Question 3

What is the heritability of major depressive disorder?

Answer 3

> 40% for women

> 30% for men

Question 4

What is the occurrence rate of bipolar disorder?

Answer 4

4% of the population

Question 5

What is the heritability of bipolar disorder?

Answer 5

~70%

Question 6

What is the occurrence rate of schizophrenia?

Answer 6

0.3-0.7%

Question 7

What is the age of onset for schizophrenia?

Answer 7

18-25

Question 8

What is the heritability of schizophrenia?

Answer 8

46%

Question 9

What is the heritability of autism?

Answer 9

30%

Question 10

What in the age of onset for ADHD?

Answer 10

7

Question 11

What is the occurrence rate od ADHD?

Answer 11

3-5% globally

Question 12

What is the heritability of ADHD?

Answer 12

75%

Question 13

What does GWAS stand for?

Answer 13

Genome Wide Association Study

Question 14

What was the purpose of GWAS?

Answer 14

To look for particular SNPs (Single Nucleotide Polymorphism) that occur more frequently in a test population than in a matched control population

Question 15

What was the purpose of GWAS?

Answer 15

To look for particular SNPs (Single Nucleotide Polymorphism) that occur more frequently in a test population than in a matched control population

Question 16

What are the explanations for the failure of GWAS?

Answer 16

> Common vs rare variants
Gene-environment interactions
Poor mental disorder categorisation