Neurobiology & Sensory Physiology Flashcards
Central nervous system
- Brain
* Spinal Cord
Peripheral nervous system
•Nerves
Nerve cells/neurons
- functional cell respo. for nervous system signaling.
* cells specialized for communication
Function of neurons
•long distance: electrical signals
ie. Electrical impulses or action potentials
- short distance: chemical signals
- Higher order processing: brain & ganglia
Multiple Sclerosis(MS)
- Autoimmune condition
* immune system attacks CNS=demyelination
Neuron structure
- Cell body
- Dendrites
- Axon
- Axon hillock
- Axon terminal
- Pre & post synaptic cells
Nerve structure in detail
•ENDONEURIUM: protective sheath
🔹axon+myelin sheath
- FASCICLE: group of ENDONEURIUMS
- PERINEURIUM: protective sheath of connective tissue around Fascicles
•EPINEURIUM: encloses
🔹several fascicles+blood supply+fatty tissueJ
3 main functions of nervous system
- Sensory function
- Integrative function
- Motor function
Types of nerve cells
- Neurons
2. Glial cells
Types of neurons
SIM
🔹sensory/afferent neurons
🔹interneurons
🔹motor/efferent neurons
Types of glial cells
MAYO=CNS
🔺microglia= CNS
🔺 astrocyte=CNS
🔺ependymal cells=CNS
🔺oligodendrocytes=CNS
🔹Schwann cells= PNS
Resting/graded/ membrane potential
“Ironic name as a lot of work is done to get it to rest”
•sodium channels
•potassium channels
NB. Passive channels therefore always open.
🔹sodium-potassium pump: Co-transporter •against [] gradient •uses ATP to maintain resting potential ***think of revolving door AIM: -ve inside \+ve outside
Action potential
- voltage gated channels
- action potential
🔹steps:
- Resting state
- Depolarization
- Repolarization
- Hyper polarization
- resting state
Conduction of action potential
Soma:Axon:Axon
a) depolarized:resting: resting
b) repolarize:depolarize: resting
c) resting:repolarize: depolarize
Node-node
*Saltatory(To jump or skip)conduction
•Increases speed of nerve impulse
•saves neuron energy by preventing slow inward leak of Na and K
•uses myelin as insulating layer(think of sweater)
•moves signal fast by trapping
+ve charge.
**prevents need for new action potential each time
Synaptic transmission
- Action potential reaches pre-synaptic membrane triggering opening of Ca2+ ions.
- Ca2+ triggers exocytosis of neutransmitters in synaptic vessels.
- Neurotransmitters diffuse across synaptic cleft
* many neurotransmitters receptors=ligand gated.
***since synaptic cleft needs to be clear of neurotransmitters after signal has passed, remaining neurotransmitters:
•broken down by enzymes
•re-uptake in pre-synaptic neuron
•diffuse away from synaptic cleft where later destroyed
•taken up by glia cells for metabolic fuel