Neurobiology of Attention Flashcards

1
Q

Attention

A

Taking possession of the mind, in clear and vivid form, of one out of several simultaneously possible objects or trains of thought.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Endogenous attention

A

Internal shift in attention
driven by intention
top-down
voluntary control

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Covert attention

A

An internal shift of attention without moving the eyes.
Important in social interaction, sports, combat
laboratory setting - same photoreceptors activated on retina

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Spatial attention

A

Attending to a specific location in space.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Object-based attention

A

Attending to multiple features of an object as a whole.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Receptive fields RF

A

Part of sensory space that elicits a response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Prefrontal cortex (PFC)

A

The region of the brain that represents abstract concepts and goals and sends feedback to visual cortices (top-down projections)
modifies incoming sensory information with a delay

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Frontal Eye Field (FEF)

A

A region in the prefrontal cortex that elicits saccades to specific location
insert electrode in FEF - finds region the eyes are driven to

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

statistics

A

5 million cone cells in the retina
200,000 RGCs in the fovea (no. of information channels)
info entering the brain per second = 7 million bits per second

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

role of attention

A

prevents an overload of information
attention is a limited resource

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

overt attention

A

orientating by moving our eyes
filters out by looking away
shift in attention + gaze shifting

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

exogenous attention

A

something salient appears e.g. sound
bottom up
reflexive (involuntary)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

feature-based attention

A

attend to a specific feature such as colour, orientation, direction of motion
location-independent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

how to record attention

A

MRI scanner
electrodes (monkeys)
lick port in response to stimulus (mice)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

tuning curve

A

describes what stimuli a cell likes to fire in response to

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Does the RF change during different stimuli?

Moran & Desimone, 1985

A

record cell in monkey, find RF
effective and ineffective stimuli - place in RF

less firing when animal attends to ineffective stimulus (RF shrinks around location of attending)
competition within neuronal receptive field

17
Q

Responses to the same stimulus with & without attention

A

train monkey to attend to location of RF and away
attended = more stronger firing
unattended = weaker firing

18
Q

advantages of mice models

A

sophisticated cognitive abilities
small brain (multiple recordings)
2 photon imaging
transgenic mice

19
Q

5CSRTT

A

5 choice serial reaction time task
touch panel when light comes on in 5 spatial locations

top down inputs from anterior cingulate cortex to V1 are needed only when task is attentionally demanding

20
Q

silencing ACC-V1 inputs

A

use cre-dependent inhibitory DREADD and retro-AAV expressing Cre
eliminates top down projections - reduces accuracy

21
Q

how does attentional modulation occur

A

disinhibtion
VIP interneurons inhibit SOM interneurons
Pyramidal neurons are activated