Neurobiology and Neurochemistry of Cognition Flashcards
types of memory?
semantic memory (facts) long term memory short term memory working memory (immediate conscious perception memory in-action) procedural memory (memory of how to complete a task, used unconsciously) episodic memory (things that have happened)
damage to wernicke’s area causes what?
fluent aphasia/receptive dysphasia
can speak fluently but doesnt make sense in response to the questions/conversation
damage to brocas area causes what?
responses show an
expressive aphasia
attempt to make sense and are in correct context
just difficult to actually get the words out
what are boradmans areas?
52 areas of the cortex defined by their different cytoarchitecture
multi-store model of memory?
environmental input > sensory memory > committed to short term memory with increased attention > committed to long term memory with rehearsal
can be retrieved from long term memory back to short term memory for recall
function of hippocampus in memory?
important for encoding information from short term memory to long term memory
what is agnosia?
difficulty recognising objects
what is dyspraxia?
loss of coordination
associated with autism but also with dementia
2 main pathological features of alzheimers?
amyloid plaques
neurofibrilary tangles
what causes the neurofibrilary tangles?
hyperphosphorylated tau protein in microtubules
cholinergic projections in cognition?
acetylcholine involved in transmission
striatal interneurones = motor control
nucleus basalis of maynert (attention/arousal)
medial septal nucleus (learning and memory)
brain stem nuclei
what do acetylcholinesterase inhibitors do?
boost cholinergic transmission but dont treat the underlying pathological process
3 examples of cholinesterase inhibitors?
donepezil
galantamine
rivastigmine
what is memantine?
non-competitive NMDA antagonist licensed to treat alzheimers
which is most affected by vascular dementia, grey or white matter?
white