Neuroanatomy Flashcards
Cranial nerves 2-12 are attached at the ___
Brainstem
Alternating hemiplegias
Central brainstem lesions
Motor cranial nuclei
VII, nucleus ambiguus
Sensory spinal cord
Dorsal roots
Posterior columns
Lateral spinothalamic tract
Anterior white commissure
Motor spinal cord
Lateral Corticospinal tract
Anterior horn
Lateral reticulospinal tract
Brainstem sensory
Spinal lemniscus Medial lemniscus Trigeminal lemniscus Lateral meniscus Descending tract of V
Brainstem motor
Corticospinal tract
Corticobulbar tract
Brainstem special systems
Medial longitudinal fasci
What does trauma to the head cause
Hematoma, herniation, hemorrhage’s
Subdural hematoma
Bridging veins get displacement of the left cerebral hemisphere and midline shift..lateral ventricle enlarged
Problem with 9 vs 10
9-oropharyngeal sensation:gag reflex
10-laryngoscopy, dysphonia, dysphagia
9
Sensory gag
10
Motor gags
Phwhat innervates the pharynx
Pharyngeal plexus (in buccopharyngeal fascia)
Sensory of pharyngeal plexus
GVA from the pharyngeal branch of glossopharyngeal nerve
Pharyngeal plexus motor
SVE fibers from vagus
What conveys afferent information from gag reflex
GVA fibers from pharyngeal plexus
Branches of 9
Pharyngeal nerve to pharyngeal plexus
Sensory GVA to mucosa of post1/2 tongue and pharynx and sensory (SVA) to taste buds of post 1/3
Motor SVE to stylopharngeus muscle
Spastic hemiplegic involves __ ___
Corticospinal tract
Corticospinal tract
Upper motor neurons
Lesion in Corticospinal tract
Contralateral spastic hemiplegia
What is contralateral spastic hemiplegia
Hyperreflexia, hypertonia, paralysis, and disuse atrophy
Lesion of ventral roots
Lower motor neuron paralysis
LMN paralysis
Atonia, areflexia, fasciculation, flaccid paralysis
Supranuclear fascial palsy
Corticobulbar tract
Corticobulbar originates where
Int he head region of the precentral gyrus
What is the course of the Corticobulbar fibers
Through the gene of the internal capsule and cerebral peduncle as uncrossed CBT.
Decussate in lower pons (between I and VII) and descend in the lower brainstem as crossed CBT
Unilateral lesion of uncrossed CBT
Supranuclear facial palsy
Unilateral lesion of crossed CBT (below the decussation
Ipsilateral cranial nerve palsies
The __ quadrant of the face is unaffected by unilateral lesions of the Corticobulbar fibers
Upper
Unilateral lesion of the Corticobulbar fibers to the facial nucleus result in prarlysis of the __ __ __ of the face
Controlateral lower quadrant
Proprioceptice and 2 point tactile discrimination loss below L2 dermatomes indicates involvement of what
Fasciculus gracillis
Bilateral atonia, areflexia and flaccid paralysis involving C7-T1 motor dermatomes indicates involvement of which of the following
Anterior horn neurons
LOWER MOTOR NEURON PARALYSIS
Hemianalgesia and thermal hemianesthesia indicates involvement of what
Spinal lemniscus
Alternating hemianalgesia indicates involvement of which of the following
Descending tract V (8 and 12)
What causes alternating hemianalgesia
Lesion of the descending tract of V and the spinal lemniscus
CPA and Wallenberg syndrome
Have alternating hemianalgesia
Lesion of V
Complete anesthesia of the face and paralysis of the muscle of mastication
Bilateral diminution of hearing with a more prominent loss in one ear indicates involvement of what
Lateral lemniscus
Unilateral lesion of lateral lemniscus, inferior colliculus, brachium of the inferior colliculus and medial geniculate body result in
Bilateral diminution of hearing with a more prominent hearing loss in the contralateral ear
One horizontal gaze to the right, the left eye does not adductor and the right eye shows nystagmus indicators involvemtn of which
Medial longitudinal fasciculus
Left eye INO (intraocular opthalmoplegia)
Horizontal base to the left is normal, disturbances in gaze to the right
Gaze to the left shows no addition of left eye and nystagmus in right eye
Left internuclear opthaloplegia
Normal horizontal gaze to the left
Disturbance in horizontal gaze to the right
With left INO why do we get normal horizontal gaze tot he left and not to the right
The oculomotor nucleus on the left and right abducens nucleus are not communicating so have no abduction on left and have nystagmus on right
What does the abducens nucleus mediate? What about the oculomotor
Abducens-lateral rectus
Oculomotor-medial rectus
Left homonymous hemianopia indicates involvement of which of the following
Optic tract
Unilateral lesions of the lateral geniculate body, complete optic radiations or visual cortex result in ___ ___ ___
Contralateral homonymous hemianopsia
Left homonymous hemianopia would indicate a lesion on the _ visual pathway
Right (optic tract, lateral geniculate body or complete optic radiations)
Internal strabismus indicates involvement of what
Abducens nerve
CN1 injury
Specific olfactory challenges
CN2 injury
Visual fields, light reflexes, acuity
CN3 right
Cardinal signs of gaze
CN3 left
Complete ptosis, ext. strabismus, pupil dil
CNIV right
Cardinal signs of gaze
CN IV left
Inability to adduct and depress
CNVI right
Cardinal signs of gaze
CN6 left
Internal strabismus
CNVII
Muscles of facial expression
CNVIII
Unilateral impaired hearing
CNIX
Oropharyngeal sensation: gag reflex
CNX
Laryngoscopy, dysphonia, dysphagia
CNXI
Inability to shrug shoulder (trap) or flex or flex and rotate head opposite affected muscle (scm)
CNXII
Paralysis, fasciculataions, derivation of protruded tongue to affected side
Contralateral
Sensory or motor deficits occurring not he opposite side of the causative lesion
Lesion right motor cerebral cortec
Contralateral paralysis of the left side of body
Ipsilateral
Sensory of motor deficits occurring on the same side as the causative lesion
Destruction fo the posterior column of spinal cord on right side
Ipsilateral loss of proprioception and tactile discrimination fromt he right side of the body below the level of the lesion
Afferent
Sensory
Efferent
Motor
Somatotropin
Sensory or motor pathways convey their fibers in a highly organized laminated fashion as they ascend or descended to specific regions of the cortex
Parts of cortec, major sensory and motor(pyramidal)
Homunculus
Cartoon of exaggerated proportions of the cortical map
Fasciculus
Referring to a bundle of nerves
Tract
Fasciculus comprised of nerve fibers that have common origin, termination and function
Lemniscus
Crossed secondary nerve fibers in a conscious sensory pathway
Flax herniation
Cingulate gyrus herniate across the midline beneath the free edge of the falx
Ie midline shift
Tectorial or uncal herniation
Hernate cerebrum under falx cerebri and/or through the tentorial notch
Herniation of th uncus through the incisors compresses and displaces the ___
Midbrain
Bilateral compression of th midbrain reticular formation results in a progressive decrease int he level of _
Consciousness
Tonsillar herniation
Space expanding massies in posterior cranial fossa Macy abuse cerebellar tonsil to herniate through he foramen magnum which can compress the lower medulla.upper cervical spinal cord seen in Arnold chair I malformation
Expanding masses int he posterior cranial fossa may ___displace the superior portion of the cerebellum through the tentorial notch and compression the midbrain and related structures
Superiorly
Cranial nerve and nuclei lesions
Ok
Unilateral lesion spinal lemniscus
Contralateral hemianalgesia and thermal hemianesthesia. Loss of passive touch may be masked by the intact posterior columnmedial lemincasl system
Terminates VPL\contraleral hemianalgesia BODY
Unilateral medial lemniscus
Maintains somatopic organization of its fibers throughout the brainstem. It ascends, the position of fibers from the upper and lower extremities rotate 90 degrees
-loss of proprioception, two point tactile discrimination and vibratory sensation on the opposite side of the body and limbs
Unilateral trigeminal lemniscus
Okascends adjacent to medial lemniscus in brainstem and terminated at VMP nucleus of dorsal thalamus
Conveys pain, temperature and crude tactile sensation from the opposite 1.2 of face. Located between medial lemniscus and spinal lemniscus
Trigeminal reticulothalmic pathway
C flow pain neurons from the subnucleus caudalis project bilaterally to the brainstem RF as trigeminoretuclar fibers.
Unilateral lateral lemniscus
Okconveys bilateral auditory information, predominantly to opposite ear. Located in lateral brainstem
Both dorsal and intermediate stria decussate I th e upper medulla and ascend into e contralateral lateral lemniscus
- auditory path
- complete deafness
- sudden loss of hearing BILATERAL diminution of hearing
- but more prominent loss to contralateral ear
Unilateral medial longitudinal fasciculus
Internuclear opthalmoplegia
Abnormal response to horizontal gaze int he direction opposite the side of the lesion
Unilateral-impairment or loss of adduction of ipsilateral eye and nystagmus of the abducting eye
Unilateral corticospinal lesion
Unilateral-contralateral spastic hemiplegic or spastic hemiparesis
Descends through the corona radiata, internal capsule, cerebral peduncle, pons and upper medulla. In lower medulla most decussate at pyramidal decussation and form LCST
LCST-descends in lateral funiculars . Most terminate in neuronal pools at all levels of spinal cord (spinal reflex circuits)
Unilateral LCST lesion-ipsilateral paralysis or paresis of the distal limb musculature innervated by those spinal segments below the level of the lesion
Anterior CTS-lesion little effect
Corticobulbar tract unilateral lesion
Arise from large pyramid ally shaped neurons of beta in primary and premotor cortices with CST
(Originate in head region of precentral gyrus..course through genu of internal capsule and cerebral peduncle as uncrossed CBT -unilateral lesions of uncrossed cause contralateral supranuclear facial palsy. The decussate in lower pons and descend in lower brainstem, unilateral lesions below decussation may cause some ipsilateral CN palsies)
Descending tracts
Lesion causes UMN paralysis
-spastic paralysis off the antigravity muscles (hypertonic, hyperreflexia, babinski sign, clonus and disuse atrophy)
-SUPRANUCLEAR FACIAL PALSY
Brainstem lesion: alternating hemiplegias variations
Lesion of descending tract of V
And spinal lemniscus
Part of CPA and Wallenberg
-lesio in five causes complete anesthesia of face and paralysis of muscles of mastication
Syndrome of PICA / Lateral Medullary SYndrome/Wallenberg
Displacement of the PICA on angiograms of the posterior cranial fossa may indicate the presence of a space occupying mass such as a tumor. Thrombosis of the PICA
Causes dysphagia, dysphagia, alternating hemianalgesia
Involved descending 5
- destruction fo the spinal lemniscus results in contralateral hemianalgesia
- destruction of the descending tract of V results in ipsilateral loss of pain and temperature sensations from the face (alternating hemianalgesia refers to ipsilateral loss of pain and temp from face and contralateral loss of pain and temp from body)
- destruction of the glossopharyngeal and vagus nerve
- destruction for he nucleus ambiguus
- destruction of the solitary nucleus results in ipsilateral loss of visceral sensations and reflexes from the palate and pharynx. Ipsilateral loss of taste from 1.2 of tongue and pharynx
- destruction of spinocerebellum tracts may result in asynergia or hypotonia
- irritation of the vestibular nuclei may result in nystagmus
Cerebellopontine angle syndrome
Tumor posterior cranial fossa-acoustic neuroma(compress lateral aspect of pone, cerebellum and medulla)
-destruction of the vestibulocochlear nerve results in deafness and vestibular disturbances
-destruction of the facial nerve results in Bell’s palsy
-alternating hemianalgesia refers to ipsilateral loss of pain and temperature sensations from the face and contralateral loss of pain/temperature sensations fromt he body
(Destructing if descending 5 results in ipsilateral loss of pain/temp sensations from the face…destruction oft he spinal lemniscus results in contralateral hemianalgesia of the body)
-involvement of the cerebral artery peduncle results in some degree of ipsilateral cerebellar ataxia, intention tremor, dysmetria and dysdiadochokinesia
Benedikts syndrome
Ipsilateral CN3 palsy and contralateral hemitremor
Diplopiaa
Tremor
Ataxia
Contralateralhemiparesis(CST)
Oklesion of the midbrain tegmentum
- destroy oculomotor nerve results in external strabismus, pupillary dilation and complete ptosis
- destruction of the medial lemniscus results in a contralateral loss of proprioception and 2 point tactile discrimination fromt he body and limbs
- lesionsof the red nucleus, fibers of the superior cerebellar peduncle and midbrain tegmentum rpesent with ipsilateral oculomotor palsy and contralateral motor dysfunction such as tremor ataxia or choreiform movements. Also spacicity
Parinaud syndrome
Lesion of superior colliculus which contains a center for controlling upward gaze
-paralysis of upward gaze
Due to a pineal tumor or varix of the great vein of Galen
Also destroy the posterior commissure and concomitant loss of the consensual light reflex
Thalamic syndrome(dejerine-Roussy syndrome)
Okie to thrombosis of the posterior choriodal or thalamogeniculate branches of the posterior cerebral arteries
- state of constant spontaneous pain without appropriate external stimulus; diffuse
- modification of emotional control
- patient exhibits extreme mood swings from laughter to sobbing within short time
- may involve contralateral hemihypalgesia (crawling sensation) hemiparesis, homonymous hemianopia, or auditory deficits
Lesion MLF (medial longitudinal fasculus)
Converts vestibular influences to the cranial nerves 3, 4, 6 and also has fibers or oculomotor system
Lesion-internuclear ophthalmoplegia
- abnormal response to horizontal gaze in the direction opposite the side of the lesion
- impaired of loss of adduction of the ipsilateral eye and a nystagmus of the abducting eye
Lesion paramedian pontine reticular formation
Critical center for horizontal gaze, which is an enhancement of the RF immediately adjacent to abducens nucleus. It is the staging and coordinating area for the oculomotor system. Sends fibers to the abducens nucleus of same side for influencing ipsilateral lateral rectus. Also projects through the contralateral MLF to the contralateral oculomotor nucleus that innervated the medial rectus
Includes lateral gaze center-
Unilateral lesion-paresis or paralysis of horizontal gaze toward the same side of the lesion and a gaze preference away fromt he side of the lesion. (Due o destruction of fibers from it to the ipsilateral abducens nucleus and contralateral oculomotor nucleus
Fibers from the vestibular nuclei and the adjacent paramedian pontine reticular formation decussate int he lower pons and ascend to the oculomotor nucleus in the midbrain .
Lesion symptoms left
Horizontal gaze to right is normal
Horizontal gaze to left showed that the right eye did not adductor and the left eye showed a lateral nystagmus
Both eyes could adductor during convergence
The vestibular nerve has direct connection to it
Parkinson’s disease neuroanatomical basis
Subcortical degeneration of substantia nigra, globus pallidus, upper brainstem nuclei, an
Nigrostriatal fibers are dopaminergic fibers that originate in the pars compacta of the substantia nigra and terminate in the caudate and putamen (striatum) the neurons int his area of the substantia nigra are destroyed in parkinsons)
Absence of descending tracts and neuronal pools(they convey either facilitatory or inhibitory influences upon lower motor neurons)
Most descending motor neurons terminate in lower motor neuron pools.
Neurons in pars compacta are destroyed in parkinsons.
Nigrostriatal fibers (dopaminergic fibers)
Huntintinton chorea neuroanatomical basis
Nigro-striatal fibers are dopaminergic fibers that originate in the pars compacta of the substantia nigra and terminate int he caudate and putamen (striatum) the neurons in this area of the substantia nigra are destroyed in parkinsons
Destruction of the inhibitory GABAnergic fibers in the striatonigral fibers are involved in huntingtons
Chorea is an AD motor disorder on chromosome 4
Normally the gene called Huntington has CAG repeats MORE
SUDEN IRREGULAR AND INVLUNTARY MOVEMENTS
Striatonigral fibers (GABAnergic fibers) Destroy the inhibitory, GABAnergic fibers on the SN fibers)
Hemibalism neuroanatomical basis
Parkinsons
Issue with descending tracts
Unilateral lesion in subthalamus (connected to globus pallidus)-regulated output of basal ganglia
Unilateral lesion in subthalamus results in contralateral movement dysfunction characterized by wild movements, flailing or both upper and lower extremities. May be due to the reduction or loss of inhibition of the globus pallidus by the subthalamus.
Athetosis neuroanatomical basis
Slow involuntary convoluted writhing movements of fingers, hands, toes, and feet
From cerebral palsy,
Huntingtonss
Korsakoff syndrome (wernicke’s encephalopathy)
Due to bilateral destruction of the mammillary bodies and the dorsomedial thalamic nucleus.
Sequalea of long term alcohol abuse and chronic thiamine defiency
Clinical-impairment of recent memory due to defective encoding at the time of original learning
Memory retreival int act
CONFABULATION to fill gaps in story
OR PITUITARY TUMOR (get bitemporal hemianopsia)
Uncal herniation/tentorial herniation
Rapid bleeding expands the epidural space, pressing upon the adjacent cerebral hemisphere and herniating the cerebrum under the falx cerebri (falx herniation)
And/or through the tentorial notch (tentorial or uncal hernation)
Herniation of the uncus through the incisors compresses and displaces the midbrain. Bilateral compression of the midbrain reticular formation results in a progressive decrease in the level of consciousness
Cerebral cortex lesions
Ok
Receptive aphasia
From fluent paragrammatical aphasia from wernickes
Wernickes aphasie-can Speak fluently but that weird speech pattern
Speech patterns demonstrate numerous word substitutions, neologisms (new word creation), and a circumlocution of language that belies an underlying fundamental comprehension deficit .
Get from damage to wernickes are 22…assembly for language CANT COMPREHEND THE SPOKEN OR WRITTEN WORD
Gerstmann syndromes
Due to lesion of dominant parietal lobe
Characterized by finger agnosia, right-left disorientation, dysgraphia and dyscalculia
*superior parietal lobule-lesion may cause failure to recognize the body scheme on the opposite side
FINGER AGNOSIA
Agnosias
From lesion in superior and inferior parietal lobe
Lesion of parietal lobe may disturb our recognition of our own body parts (denial of body scheme) our ability to discrimate objects (agnosia) or our ability to perform certain complex learned motor activities
Auditory agnosia-lesion of auditory association cortec
Frontal lobe syndrome
The prefrontal lobe is functionally an extension of the Limbic lobe. It is involved int he regulation of depth of our feelings, the affective component of visceral and comatosensory sensations, motivation and personality
Prefrontal tumors, infarcts, or lobotomies may cause patient to be easily distracted, unable to plan, tactless, extroverted, without emotional tensions, or released from inhibitions. No change in intelligence
Characterized by apathy, occasional euphoria, abruptly irritability and socially inappropriate behavior
Can’t comprehend spoken words
Auditory agnosia
Associative visual agnosia
Infarction of left occipital lobe and posterior corpus callosum secondary to occlusion fo the posterior cerebral artery may disconnect language from the visual cortex
Inability to demonstrate how to produce a voluntary cough
Agnosia
Lesion of dominant hemisphere resulting in apraxia is frequently associated with what
Agnosia
Visual agnosia
Can’t visually recognize objects or pictures
How get associative visual agnosia
Infarction of left occipital lobe and posterior corpus callosum secondary to occlusion of the posterior cerebral artery
Lesion of the middle two thirds of cerebral peduncle
CST and Corticobulbar biers
Contralateral hemiplegia
Contralateral supranuclear facial palsy
Red nucleus
Part of RF
Descending pathway for extrapyramidal systems
Lesions
Spacisity seen with UMN
Lesions of RN
Intention and or resting tremors bc dentatorubral and dentate-Rubio-thalamic fibers fromt he superior cerebellar peduncle course through the RN
Lesion of genu of internal capsule
Conveys Corticobulbar fibers
Contralateral supranuclear facial palsy and some other cranial nerve somatic motor deficits
Obstruction of cerebral aqueduct
Internal hydrocephalus of the lateral third ventricle
acoustic neuroma
Common tumor of posterior cranial fossa in adults
CPA
Vertebral arteries join to form what
Basilar artery at level of medulla
Chiari malformations
Check upper cervical cord for a syrinx
Tonsillar herniation
Mas herniate the cerebellum superiorly, inferiorly or both
LMS
Medulla infarct
Dysphagia, dysphagia, and/or alternating hemianalgesia
See trigeminal and vestibulocochlear nerves
Ok
Lateral medullary syndrome
PICA problem from medulla damage
Dysphagia, dysphagia and/or alternating hemianalgesia
What supplies cerebellum
PICA
Why may PICA branches be displaced
Space occupying lesion in PCF
May herniate cerebellum too (tonsil)
What level do we see tonsil
Metencephalon
Michele eyes mesencephalon
Red nucleus
Mickeys dot under chin
CA
CPA/cerebellopontine angle syndrome
Mass of acoustic neurons of vestibulocochlear nerve
Obstruction CA
Hydrocephalus third and lateral ventricles
What in in the genu
Corticobulbar and corticoretuclar tract
Lesion genu
Supranuclear facial palsy and CN somatic motor deficits
Red nucleus
Part of reticular formation and is part of major descending pathway for the extrapyramidal system (corti our real-spinal path)
Lesion red nucleus
Spasticity seen with UMN lesions
Resting tremor-damage dentatorubral
Dentatorubral fibers
From superior cerebellar peduncle course through the RN
What level is middle peduncle on
Mesencephalon
What is in cerebral peduncle
CSST
Damage to CST at cerebral peduncle along with Corticobulbar fibers
Contralateral hemiplegia
Also maybe contralateral supranuclear facial palsy
What does insular cortex do
Visceral sensation and pain
Subthalamus nucleu
Subthalmic nucleus
Red nucleus
Substantia nigra
Amygdaloid to hypothalamus
Stria terminalis
Mamilllothalmic
Hypothalamus to thalamus
__ lobe lesion may cause olfactory hallucinations
Temporal
Injury to optic nerve
Can be from demyelination
MS
Visual acuity
Visual field defects
Damage oculomotor
Ipslateral oculomotor palsy
Dilation of pupil and slowed pupillary constriction in response to light
Can’t move eye normally
Also supplies sphincter pupillary and upper eyelid muscle (levator palpebrae)
Strabismus and diplopia
Trochlear nerve damage
Diplopia from superior oblique paralysis
Down and out
Branches of trigeminal
V1 occipital
V2 maxillary
V3 mandibular (also muscles of mastication)
Bell’s palsy
Paralysis of facial muscles
What glands does facial nerve control
Lacrimal and salivary
Sign of CN7 lesion
Bell’s palsy
Loss of taste anterior two thirds tongue
Altered lacrimal salivary secretion
Lesion CNVIII
Tinnitus, vertigo, hearing deficits
Conductive deafness
External or middle ear
Sensorineural deaf
Disease in cochlea or central auditory pathway
Glossopharyngeal lesion
Absence of taste on posterior third of tongue, gag reflex absent on the side of lesion
Change in swallowing
Glossopharyngeal neuralgia
Sudden onset of pain initiated by swallowing protruding the tongue, talking or touching the palatine tonsil
Vagus nerve injury
Pharyngeal branches-dysphagia
Superior laryngeal nerve-anesthesia of the superior aspect of the larynx and paralysis of the Cricothyroidotomy muscle
Recurrent-dysphonia or aphonia
Lesion nucleus ambiguus
Nasal speech, dysphagia, dysphagia, and deviation of the uvula toward the contralateral side
Lesion facial motor nucleus
In brainstem
Atrophy of muscles of facial expression
The muscles of the face receive input from
Contralateral input from opposite motor cortex
Direct activation path
UMN to pyramida tract
Indirect path
Extrapyramidal tract which has contact with LMN
Control circuits
Basal ganglia, cerebellum, have NO direct contact with LMN
UMN
From motor cortex and synapse onto cranial nerve nuclei in contralateral brainstem (corticobulbar) or onto cells in the contralateral spinal cord (corticospinal tract)
LMN
Originate in cranial nerve nucleu(cranial nerve) or spinal cord(spinal nerves) they synapse onto muscles
What is the junction between LMN and muscle
Motor end plate
CST
Main path for all voluntary msucles
UMN
Cross at pyramids
Prefrontal cortex UMN
UMN initiate movement
Frontal lobe UMN
Do not initiate impulse
Suppress and inhibit LMN
If lose inhibitory UMN
Spasticity
CBT
UMN from motor cortex lower third
Crosses
Damage UMN
Spasticity and cant initiate skilled movement
Reflexes exaggerated
LMN damage
Flaccidity decreased muscle tone
Bilateral UMN lesion
Spastic dysarthria
Pseudobulbar dysarrhythmia
Strained phonation imprecise articulation
Unilateral UMN lesion
Flaccid dysarthria
Unilateral lower facial weakness vocal prob