Neuro Pharmacology --Objectives only Flashcards
naproxen
class
non-steroidal anti-inflammatory (NSAID)
non opioid analgesic
naproxen indications
relief of mild to moderate pain, and or inflammation
headaches
Acetaminophen
indications
relief of mild to moderate pain fever and headaches
dexamethasone
class
corticosteroid
dexamethasone
indications
anti-inflammatory
immunosuppressant agent
used for meningitis
acyclovir
class
antiviral
acyclovir
indications
herpes simplex virus (HSV)
herpes zooster (shingles)
varicella
encephalitis
acyclovir
metabolism
metabolized directly by the virus
AED drugs
moa groups
- modification of Na, Ca channels
- enhancement of GABA transmission
- reduction of glutamate transmission
- others
status epilepticus drug of choice
IV/IM/rectal biodenzapine (diazepam or lorazepam)
GABA enhancer
donepezil
class
cholinesterase inhibitors
donepezil
indications
all stages of Alzheimer dementia (mild to severe)
best effective in the earlier stages
donepezil
MOA
increase cholinergic transmission (Ach) by inhibiting cholinesterase (breaks down Ach) at the synaptic clef
CYP drugs
donepezil
bromocriptine
selegine
have to check for drug interactions
special features of donepezil
first line of prescriptions for Alzheimer’s
slows symptoms in some patients, but not all benefit
memantine
indications
symptoms of moderate to severe dementia of alzheimer’s type
memantine
moa
antagonist of NMDA glutamate receptor
memantine
special features
only symptomatic
no evidence that it prevents or slows neurodegernation
add on therapy, if no improvement with cholinesterase inhibitors then no benefit from this drug
levodopa + carbidopa
indications
parkinson disease
levodopa + carbidopa
MOA
Levodopa: circulates in blood, cross BBB, converted to dopamine in brain
if in the peripheral tissue will also be broken down SO
carbidopa: protects levodopa from breakdown/decarboxylation in peripheral tissue, can’t cross BBB
Bromocriptine
class
dopamine agonist
activates post synaptic dopamine receptors
bromocriptine
indications
parkinson disease
acromegaly (giantism)
hyperprolactinemia (pituitary tumor)
selegiline
class
MOA type B Inhibitor
selegiline
indications
parkinson disease, major depressive disorder
selegiline
MOA
selective inhibition of MAO Type B (plays role in dopamine metabolism)
alteplase
class
thrombolytics, TPA
increases blood flow, bleeding
alteplase indicatoins
acute ischemic stroke, pulmonary embolism, st-elevation myocardial infarction
alteplase
MOA
initiates fibrinolysis by binding to fibrin (breaks down) in a thrombus and converts the plasminogen to plasmin
