Neuro Pharmacology --Objectives only

Question 1

naproxen

class

Answer 1

non-steroidal anti-inflammatory (NSAID)

non opioid analgesic

Question 2

naproxen indications

Answer 2

relief of mild to moderate pain, and or inflammation

headaches

Question 3

Acetaminophen

indications

Answer 3

relief of mild to moderate pain fever and headaches

Question 4

dexamethasone

class

Answer 4

corticosteroid

Question 5

dexamethasone

indications

Answer 5

anti-inflammatory

immunosuppressant agent

used for meningitis

Question 6

acyclovir

class

Answer 6

antiviral

Question 7

acyclovir

indications

Answer 7

herpes simplex virus (HSV)

herpes zooster (shingles)

varicella

encephalitis

Question 8

acyclovir

metabolism

Answer 8

metabolized directly by the virus

Question 9

AED drugs

moa groups

Answer 9

1. modification of Na, Ca channels
2. enhancement of GABA transmission
3. reduction of glutamate transmission
4. others

Question 10

status epilepticus drug of choice

Answer 10

IV/IM/rectal biodenzapine (diazepam or lorazepam)

GABA enhancer

Question 11

donepezil

class

Answer 11

cholinesterase inhibitors

Question 12

donepezil

indications

Answer 12

all stages of Alzheimer dementia (mild to severe)

best effective in the earlier stages

Question 13

donepezil

MOA

Answer 13

increase cholinergic transmission (Ach) by inhibiting cholinesterase (breaks down Ach) at the synaptic clef

Question 14

CYP drugs

Answer 14

donepezil
bromocriptine
selegine

have to check for drug interactions

Question 15

special features of donepezil

Answer 15

first line of prescriptions for Alzheimer’s

slows symptoms in some patients, but not all benefit

Question 16

memantine

indications

Answer 16

symptoms of moderate to severe dementia of alzheimer’s type

Question 17

memantine

moa

Answer 17

antagonist of NMDA glutamate receptor

Question 18

memantine

special features

Answer 18

only symptomatic

no evidence that it prevents or slows neurodegernation

add on therapy, if no improvement with cholinesterase inhibitors then no benefit from this drug

Question 19

levodopa + carbidopa

indications

Answer 19

parkinson disease

Question 20

levodopa + carbidopa

MOA

Answer 20

Levodopa: circulates in blood, cross BBB, converted to dopamine in brain

if in the peripheral tissue will also be broken down SO

carbidopa: protects levodopa from breakdown/decarboxylation in peripheral tissue, can’t cross BBB

Question 21

Bromocriptine

class

Answer 21

dopamine agonist

activates post synaptic dopamine receptors

Question 22

bromocriptine

indications

Answer 22

parkinson disease

acromegaly (giantism)

hyperprolactinemia (pituitary tumor)

Question 23

selegiline

class

Answer 23

MOA type B Inhibitor

Question 24

selegiline

indications

Answer 24

parkinson disease, major depressive disorder

Question 25

selegiline

MOA

Answer 25

selective inhibition of MAO Type B (plays role in dopamine metabolism)

Question 26

alteplase

class

Answer 26

thrombolytics, TPA

increases blood flow, bleeding

Question 27

alteplase indicatoins

Answer 27

acute ischemic stroke, pulmonary embolism, st-elevation myocardial infarction

Question 28

alteplase

MOA

Answer 28

initiates fibrinolysis by binding to fibrin (breaks down) in a thrombus and converts the plasminogen to plasmin