Neuro PD not done Flashcards
This without the basal ganglia or cerebellum they can still move, but it just has to be alot
Slower, it would seem alot like taxia.
Primary motor and non primary cortex, it is modulated, even before the basalmganglia or the cerebellum.
.
By cerebellum it is like ataxia that they widen the base of support to not fall.
.
Without the basal ganglia it is even worse than the cerebellar issue.
.
A baby walking, they go fast and they either fall forward or they fall backwards.
This is mostly primary and non-primary motor cortex.
.
Non-primary motor cortex is
The parietal and working memeory and it is also call the suplemental.
From the PMC to the basal ganglia what is in the between
Thalamus
If the thalamus sendsalot of information it is excited?
Yes
The basal ganglia modulates the PMC signal and then sends that to the
Spinal cord
The ______ also besides the basal ganglia sends the PMC’s signal to the spinal cord.
Cerebellar.
The NPMC, non-primary motor cortex, also does what?
Modulates the information.
If you knock out the basal ganglia you loose…
Whatever control you would have have had on the thalamus.
The ________ is the key playert hat gets the information to the brainstem.
The Thalamus.
Basal ganglia loops, can it be that we do not have it?
No
What are the two things that the basal ganglia can do?
Over stimulating the thalamjs, to over inhibit it, to cause PD,
Or understimulate it and it is overexcited.
Motor cortex is ontop and in the center is
The globus pallidase
Mc on top, globus pallidase is in the center, and then we have the?
Striatum
The striatum is made of
Claudate nucleus and putamin.
Mc, globus pallidase, thalamus, and striatum(which the caudate nucleas and putamin)
.
Neurotransmitters.
GABA, ths whole thing, which is inhibitory.
Key player in neurtransmitter for the direct route is the …
GABA.
GLobus Pallidase does what to the thalamus?
Inhibits
The thalamus is inhibitory or excitatory?
Excitstory
Caudate and Putamin are supposed to?
Send out GABA an inhibitory neurotransmitter.
The activation of the STRIATUM which will release GABA to the GP, and now the GO will not release its GABA and so the Thalamus is overactive.
.
What inhibits the thalamus and with which neurotransmitter?
The GP and with GABA.
The striatum is what will end up controlling the Thalamus?
Yes,
If the STRIATUM is inhibited then the GP is not inhibited and so the thalamus will get inhibited.
.
If the striatum is active, the it activates the GP, which inhibits the thalamus, which has more excitatory.
.
Striatum is inhibited so will the thalamus be inhibited.
If the striatum is activated the thalamus will also get activated.
.
The inhibitory the indirect loop.
.
Subthalmic nuclei
Is under the thalamus is the main player of the indirect route.
The subthlamic nuclei is inhibitory?
Yes
Glumtamate excites or inhibits?
Excites
The STN is to work on the GP which we did say affects the thalamus.
.
Alcohol is a depressant, so it activates the
STN, which uses GLUTAMATE to wxcite the GP which inhibits the THALAMUS which now there is less excitation from the THALAMUS to the MOTOR CORTEX.
With PD the person is down to ____% of their usually dopamine production.
20
If it is not an underproduction it is ________ that causes PD?
It is the lack of ability to be able to use dopamine.
