Neuro Flashcards
Ascending weakness starting distally in feet. Absence of DTRs
Guillain-Barre Syndrome
Pain and parasthesias (mid to lower back), autonomic instability, and respiratory failure
Guillain-Barre Syndrome
Evolves over 2-4 weeks before reaching a plateau. Recovery is variable and dependent upon treatment received
Guillain-Barre Syndrome
Lumbar puncture will show cytoalbumic dissociation (normal cell count and high protein) in CSF
Guillain-Barre Syndrome
Variant of GBS. Ophthalmoplegia, ataxia, facial weakness, dysarthria, and areflexia. Anti GQ1B Antibodies present in serum
Miller Fisher Variant
Antibody mediated rx with interstitial and perivascular infiltration of endoneurium with inflammatory T cells and macrophages. Segmental demyelination of peripheral nerves
Chronic Inflammatory Demyelinating Polyneuropathy
Insidious. Slow and progressive. Both sensory and motor. Can have autonomic dysfunction (orthostatic hypotension, bowel and bladder probs, and cardiac problems)
Chronic Inflammatory Demyelinating Polyneuropathy
CSF has elevated protein. Sometimes biopsy is needed. Biopsy will show onion bulbing due to demyelination and remyelination
Chronic Inflammatory Demyelinating Polyneuropathy
Neurodegenerative disease of anterior motor neurons. Onset 65-70. Can be familial
ALS (Lou-Gherig’s)
Super Oxide Dismutase (SOD gene)
ALS
Mix of upper and lower motor neurons
ALS
Upper and lower motor neuron signs (spasticity, atrophy, fasciculations). Asymmetrical onset. Bulbar involvement
ALS
Classic form starts as dysfunction or weakness in one part of body and spread gradually within that part, then to rest of body.
Sporadic ALS
Ventilatory failure results in death 3 years after onset of focal weakness
ALS
Later in course patients lose PFC neurons leading to mild dementia and emotional problems
ALS
