Dementia

Question 1

Extracellular deposits of beta-amyloid in grey matter

Answer 1

Senile plaques

Question 2

Parkinsonism w/ supranuclear gaze deficits.

Answer 2

PSP (Steele-Richardson-Olsewski Syndrome)

Question 3

Pseudobulbar palsy. Dysphagia. Dysarthria. Pons and midbrain atrophy.

Answer 3

PSP

Question 4

Asymmetrical. UL onset. Extrapyramidal rigidity (Akinetic rigidity). Alien hand syndrome of UE (person won’t recognize their own hand)

Answer 4

Cortical basal ganglionic degeneration

Question 5

Asymmetrical parietal lobe atrophy contralateral to limb

Answer 5

Cortical basal ganglionic degeneration

Question 6

Decreased metabolism in thalamoparietal and medial frontal areas

Answer 6

Cortical basal ganglionic degeneration

Question 7

Degeneration of GABA and cholinergic neurons in striatum

Answer 7

Huntingtons

Question 8

Caudate and cortical atrophy

Answer 8

Huntington’s

Question 9

Subcortical dementia. Psychosis. Dysphagia. Dysarthria. Rigidity. Tremor. Liver involvement with hepatitis/cirrhosis

Answer 9

Wilson’s

Question 10

Wilsons has atrophy and hypodensity of

Answer 10

Basal ganglia

Question 11

Brick red discoloration and atrophy of basal ganglia

Answer 11

Wilson’s

Question 12

Treat with D-Penicillamine and Pyridoxine. Or Zinc acetate

Answer 12

Wilson’s

Question 13

Dementia, visual loss, and progressive hemiparesis. Occipital demyelination

Answer 13

PML

Question 14

Ataxia then dementia

Answer 14

Kuru

Question 15

Systemic, neuropsychiatric, or nonfocal neurological features. Death within 12 months. Typical EEG changes (generalized periodic sharp wave complexes). 14-3-3 protein in CSF

Answer 15

Sporadic CJD

Question 16

Flair MRI shows BL high signal in anterior basal ganglia

Answer 16

Sporadic CJD

Question 17

Flair MRI shows BL and symmetrical high signal in pulvinar nuclei of thalamus

Answer 17

Pulvinar sign of new variant CJD

Question 18

High signal within right parietal region. Low signal and sulci prominence

Answer 18

Hemorrhage amyloid angiopathy

Question 19

Dementia. BL subcortical leukoaraiosis (attenuation of white matter). At least 2 of (HTN, Cerebrovascular disease, subcortical brain dysfn > abnormal gait, muscular rigidity, neurogenic bladder)

Answer 19

Binswanger’s Type

Question 20

Cerebral, AD, Arteriopathy with Sub-cortical Infarcts and Leukoencephalopathy

Answer 20

CADASIL

Question 21

AD. Chr 19. Onset between 20-40’s. Death within 30 yrs. Recurrent strokes, dementia, migraine w/ aura, depression, and mania.

Answer 21

CADASIL