MS2

Question 1

Relaxing inflammatory demyelinating disease. Affects optic nerves and spinal cord

Answer 1

Neuromyelitis Optica (Devic’s Disease)

Question 2

Sudden vision loss, weakness in one or both eyes, loss of sensation, loss of bladder fn

Answer 2

Neuromyelitis Optica (Devic’s Disease)

Question 3

Serum NMO IgG antibody (antibody to aquaporin 4 Cl channel)

Answer 3

Neuromyelitis Optica (Devic’s Disease)

Question 4

Treat neuromyelitis Optica (Devic’s disease) with

Answer 4

Rituxumab

Question 5

Binds to CD20 (which is widely expressed on B cells) and induces B cells to enter apoptosis

Answer 5

Rituximab

Question 6

Longitudinally extensive central necrotic lesions

Answer 6

Devic’s disease

Question 7

Stimulants (methylphenidate and amphetamine salts) are used in MS to treat

Answer 7

Cognitive Dysfunction

Question 8

Most common inherited neuropathy

Answer 8

Charcot Marie Tooth disease

Question 9

Heterogenous group of genetically distinct disorders with similar presentations

Answer 9

CMT

Question 10

Type 1 CMT

Answer 10

Demyelinating

Question 11

Type 2 CMT

Answer 11

Axonal

Question 12

Type 3 CMT

Answer 12

Infantile

Question 13

AD. Peripheral demyelination from mutation in peripheral myelin protein 22 (PMP22) gene

Answer 13

Type 1 CMT

Question 14

Onion bulbing effect from demyelination and remyelination

Answer 14

Type 1 CMT

Question 15

Presents in teenage years or early adulthood. Distal muscle wasting and weakness. Affects legs first

Answer 15

CMT type 1

Question 16

Pts have very high arches and hammer toes

Answer 16

CMT type 1

Question 17

Progressive weakness. Wheelchair bound later in life with more severe phenotype. Usually don’t complain of numbness

Answer 17

CMT 1

Question 18

AD. Slower progression. Pts can continue to ambulate with cane or ankle foot orthotics to prevent foot drop

Answer 18

CMT 2

Question 19

Deterine Sottas disease also known as

Answer 19

CMT 3

Question 20

AR. Very severe. Demyelinating. Affects infants and toddlers. Delayed obtainment of motor milestones

Answer 20

CMT 3

Question 21

Decreased velocity and increased latency

Answer 21

Demylination

Question 22

Decreased amplitude (wire is damaged)

Answer 22

Axonal

Question 23

Bifacial weakness. Looks like Bell’s palsy on both sides

Answer 23

Lyme’s disease

Question 24

Numbness, neuropathic pain, gait disturbance.

Answer 24

Cobalamin (Vit B12) deficiency

Question 25

Comorbid posterior column myelopathy

Answer 25

Cobalamin Vit B12 deficiency

Question 26

B12 low and methylmalonic acid high

Answer 26

Vit B12 deficiency

Question 27

Sensory neuronopathy that mimics length dependent peripheral neuropathy

Answer 27

Pyridoxine (Vit B6) toxicity

Question 28

Auto immune disease resulting in demyelination and secondary Axonal loss.

Answer 28

Guillain-Barre Syndrome

Question 29

Focal or segmental demyelination of proximal nerve

Answer 29

Guillain-Barre Syndrome

Question 30

3/4 cases preceded by infection, immunization, or surgical procedure. Swine flu immunization. Campylobacter jejuni

Answer 30

Guillain-Barre Syndrome