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Neuro Quiz > MS2 > Flashcards

MS2 Flashcards

1
Q

Relaxing inflammatory demyelinating disease. Affects optic nerves and spinal cord

A

Neuromyelitis Optica (Devic’s Disease)

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2
Q

Sudden vision loss, weakness in one or both eyes, loss of sensation, loss of bladder fn

A

Neuromyelitis Optica (Devic’s Disease)

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3
Q

Serum NMO IgG antibody (antibody to aquaporin 4 Cl channel)

A

Neuromyelitis Optica (Devic’s Disease)

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4
Q

Treat neuromyelitis Optica (Devic’s disease) with

A

Rituxumab

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5
Q

Binds to CD20 (which is widely expressed on B cells) and induces B cells to enter apoptosis

A

Rituximab

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6
Q

Longitudinally extensive central necrotic lesions

A

Devic’s disease

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7
Q

Stimulants (methylphenidate and amphetamine salts) are used in MS to treat

A

Cognitive Dysfunction

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8
Q

Most common inherited neuropathy

A

Charcot Marie Tooth disease

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9
Q

Heterogenous group of genetically distinct disorders with similar presentations

A

CMT

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10
Q

Type 1 CMT

A

Demyelinating

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11
Q

Type 2 CMT

A

Axonal

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12
Q

Type 3 CMT

A

Infantile

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13
Q

AD. Peripheral demyelination from mutation in peripheral myelin protein 22 (PMP22) gene

A

Type 1 CMT

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14
Q

Onion bulbing effect from demyelination and remyelination

A

Type 1 CMT

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15
Q

Presents in teenage years or early adulthood. Distal muscle wasting and weakness. Affects legs first

A

CMT type 1

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16
Q

Pts have very high arches and hammer toes

A

CMT type 1

17
Q

Progressive weakness. Wheelchair bound later in life with more severe phenotype. Usually don’t complain of numbness

A

CMT 1

18
Q

AD. Slower progression. Pts can continue to ambulate with cane or ankle foot orthotics to prevent foot drop

A

CMT 2

19
Q

Deterine Sottas disease also known as

A

CMT 3

20
Q

AR. Very severe. Demyelinating. Affects infants and toddlers. Delayed obtainment of motor milestones

A

CMT 3

21
Q

Decreased velocity and increased latency

A

Demylination

22
Q

Decreased amplitude (wire is damaged)

A

Axonal

23
Q

Bifacial weakness. Looks like Bell’s palsy on both sides

A

Lyme’s disease

24
Q

Numbness, neuropathic pain, gait disturbance.

A

Cobalamin (Vit B12) deficiency

25
Q

Comorbid posterior column myelopathy

A

Cobalamin Vit B12 deficiency

26
Q

B12 low and methylmalonic acid high

A

Vit B12 deficiency

27
Q

Sensory neuronopathy that mimics length dependent peripheral neuropathy

A

Pyridoxine (Vit B6) toxicity

28
Q

Auto immune disease resulting in demyelination and secondary Axonal loss.

A

Guillain-Barre Syndrome

29
Q

Focal or segmental demyelination of proximal nerve

A

Guillain-Barre Syndrome

30
Q

3/4 cases preceded by infection, immunization, or surgical procedure. Swine flu immunization. Campylobacter jejuni

A

Guillain-Barre Syndrome

Neuro Quiz (11 decks)

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