Neuro

Question 1

Dopamine agonists

Answer 1

Bromocriptine (ergot), pramipexole, ropinerol (non ergot = preferred).

Question 2

Drugs that increase dopamine

Answer 2

Amantadine may increase release

L-dopa/carbidopa

Question 3

Drugs that prevent DA breakdown

Answer 3

Selegeline (MAOB inhibitor),

Entecapone/tolcapine (compt inhibitors, prevent dopa degradation in PNS)

Question 4

Benzropine

Answer 4

Antimuscarinic, decreases cholinergic activity in brain. Little effect on bradykinesia but improves tremor and rigidity.

Question 5

What specifically in PD is due to decreased DA?

Answer 5

Bradykinesia. So therefore, benztropine can’t fix it.

Question 6

MAOB

Answer 6

Preferentially metabolizes dopamine oer NE and 5HT, so blocking it is good for PD.

Question 7

Memantine

Answer 7

NMDA receptor antagonist used for Alzheimers. Can prevent excitotoxiity. But can cause hallucinations

Question 8

Donepezil, rivastigmine, galantamine

Answer 8

Ache inhibitors that increase cognition in AD

Question 9

Huntington drugs

Answer 9

Tetrabenzine and reserpine, prevent VMAT and dopamine release.

Also haloperidol.

Question 10

Sumatriptan

Answer 10

5ht1d agonist. Ihbitis trigeminal nerve ativation.

Question 11

Toxicity of sumatriptan

Answer 11

Coronary artery vasosopasm. So don’t use in CAD or prinzmetal.