Autonomics Flashcards

1
Q

Hemicholinium

A

Blocks transport of choline into neurons. No acetylcholine synthesis

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2
Q

Vesimacol

A

Prevents loading of Ach into vesicles

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3
Q

Botulinum

A

Blocks release of Ach vesicles

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4
Q

Metyrosine

A

Blocks conversion of tyrosine to dopa

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5
Q

Reserpine

A

Blocks packaging of dopamine into vesicles

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6
Q

Bethanecol

A

Muscarinic agonist that moves bowel and bladder. Used for postop ileus and urinary retention

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7
Q

Carbachol

A

Used for glaucoma and relief of intraocular pressure.

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8
Q

Pilocarpine

A

Used for glaucoma. Stimulates sweat, tears, soliva

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9
Q

Methacholine

A

Used to bronchoconstrict for asthma tests

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10
Q

Neostigmine

A

ACHe inhibitor used to reverse neuromuscular blockade. Also used in myesthenia gravis. NO CNS penetration

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11
Q

Physostigmine

A

Penetrates CNS, used in atropine poisoning.

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12
Q

Pyridostigmune

A

used for myesthenia gravis

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13
Q

Donepezil, rivastigmine, galantamine

A

Ache inhibitors used to increase cognitive ability

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14
Q

Edrophonium

A

Short lasting ache inhibitor used to diagnose MG

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15
Q

Cholinesterase inhibitor poisoning

A

Organophosphates irreversibly inhibit ACHE. Causes bradycardia, bronchoconstriction, diarrhea, lacrimation, unination, miosis, salivation.

Treat with atropine and pralidoxime.

Poisoning usually seen in farmers.

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16
Q

Atropine

A

Muscarinic antagonist used for the eye. Causes mydriasis and cycloplegia

17
Q

Benztropine

A

Antimuscarinic used for PD

18
Q

Scopolamine

A

Antimuscarinic used for motion sickness

19
Q

Ipratropium/tiotropium

A

Used for asthma/COPD

20
Q

Oxybutynin/darifenacin/solifenacin

A

Used to reduce urgency in cystitis

21
Q

Glycopyrollate

A

Preoperative use to reduce airway secretions. Also used in peptic ulcers

22
Q

Epinephrine

A

Beta>alpha.

23
Q

Norepinephrine

A

a1>a2>b

24
Q

Isoproterenol

A

B1=b2 agonist

25
Q

Dopamine

A

D1=D2>b>a.

26
Q

Dobutamine

A

B1>b2=a. Used for heart failure. Has inotropic effects.

27
Q

Phenylephrine

A

A1>a2

28
Q

Albuterol

A

B2>b1

29
Q

Treat cocaine intoxication with beta blockers?

A

NO WAY! unopposed alpha effects can lead to extreme hypertension

30
Q

A2 agonists

A

Clonidine = used for hypertensive urgency, also ADHD and severe pain

Methyldopa - used to treat hypertension in pregnancy

31
Q

Methyldopa side effects

A

Coombs positive hemolytic anemia, SLE like syndrome

32
Q

Nonselective Alpha blockers

A

Phenoxybenzamine (irreversible)- used to treat pheochromocytoma
Phentolamine (reversible) - used in tyramine crisis

33
Q

A1 selective alpha blockers

A

Prazosin, tamulosin, doxazosin. Used to treat the urinary symptoms of bph (relax bladder). Prazosin also used to treat PTSD.

Can cause first dose hypertension, dizziness, headache

34
Q

A2 blocker

A

Mirtazepine used for depression

Sedation, increased serum cholesterol, increased appetite

35
Q

B1 selective antagonists

A

Acebutolol, betaxolol, carvedilol, esmolol, atenolol

36
Q

Non selective beta antagonists

A

Nadolol, pindolol, propanolol, timolol

37
Q

Nonselective alpha and beta antagonists

A

Carvedilol, labetalol

38
Q

Toxicity of beta blockers

A

Impotence, sedation, depression, dyslipidemia (metoprolol). CAN use in diabetics regardless of theoretical risks.