Autonomics Flashcards
Hemicholinium
Blocks transport of choline into neurons. No acetylcholine synthesis
Vesimacol
Prevents loading of Ach into vesicles
Botulinum
Blocks release of Ach vesicles
Metyrosine
Blocks conversion of tyrosine to dopa
Reserpine
Blocks packaging of dopamine into vesicles
Bethanecol
Muscarinic agonist that moves bowel and bladder. Used for postop ileus and urinary retention
Carbachol
Used for glaucoma and relief of intraocular pressure.
Pilocarpine
Used for glaucoma. Stimulates sweat, tears, soliva
Methacholine
Used to bronchoconstrict for asthma tests
Neostigmine
ACHe inhibitor used to reverse neuromuscular blockade. Also used in myesthenia gravis. NO CNS penetration
Physostigmine
Penetrates CNS, used in atropine poisoning.
Pyridostigmune
used for myesthenia gravis
Donepezil, rivastigmine, galantamine
Ache inhibitors used to increase cognitive ability
Edrophonium
Short lasting ache inhibitor used to diagnose MG
Cholinesterase inhibitor poisoning
Organophosphates irreversibly inhibit ACHE. Causes bradycardia, bronchoconstriction, diarrhea, lacrimation, unination, miosis, salivation.
Treat with atropine and pralidoxime.
Poisoning usually seen in farmers.