Neuro

Question 1

Myasthenia gravis path

Answer 1

Autoantibodies to post-synaptic Ach receptors, especially eye and face

Question 2

Myasthenia gravis hx/pe

Answer 2

*Worsens with repetitive use

Question 3

Myasthenia gravis dx/tx

Answer 3

?

Question 4

Lambert-Eaton syndrome path

Answer 4

Autoantibodies to presynaptic membranes

Question 5

Lambert-Eaton syndrome hx/pe

Answer 5

Weakness
Autonomic dysfunction
Reduced reflexes

*Improves with repetitive use

Question 6

Alzheimers path, presentation, dx, tx

Answer 6

Loss of cholinergic neurons

Loss of executive function
Personality change

CT: diffuse brain atrophy

Cholinesterase inhibitors: donepizil, galantamine, rivastigmine

Question 7

Parkinson’s path, presentation, dx, tx

Answer 7

Dopamine agonist: amantidine

Question 8

Multi-infarct dementia path, presentation*, dx, tx

Answer 8

HTN

STEP-WISE progression…less smooth than Alzheimer’s
Focal neurologic sx

CT?

Question 9

Parinaud syndrome path, presentation*

Answer 9

Rostral midbrain lesion, usually pinealoma or germinoma

Impaired VERTICAL gaze
Collier’s sign: eyelid retraction
Possibly early puberty