Neuro Flashcards
Treatment of CVA
If CT shows ischaemia
Thrombolysis within 4.5 hours
Thrombectomy if within 6 hours with thrombolysis for proximal anterior circulation demonstrated by CTA
If unable to- aspirin 300mg for 2 weeks
If thrombolysis given- aspirin 24 hours after repeat CT
Ix for SAH
CT head- non contrast
>12 hrs later- LP for xanthochromia
CI to thrombylysis
ABC SHIP
Bleeding- GI bleed in 3 weeks, LP in 7 days
Coagulation problems
Stroke <3 months
Uncontrolled Hypertension- >200
Intracranial neoplasm
Pregnancy
Scoring systems of stroke
NIHSS- quantifies severity
ROSIER- differentiate between strokes and mimics
Mx of TIA
Aspirin 300mg
Unless taking warfarin, DOAC, bleeding disorder- CT head
Or >7d since sx
When to give carotid endarterectomy
When occlusion is >70%
What is total anterior circulation infarct and its symptoms
Middle and anterior cerebral
Unilateral hemiparesis +/- hemisensory
Homonymous hemianopia
Cognitive dysfunction
Posterior inferior cerebellar infarct symptoms
Lateral medullary syndrome Loss of pain and temp ipsilateral face, loss on contralateral limbs
Ataxia, nystagmus
Can get difficulty swallowing
Anterior inferior cerebellar infarcts
Loss of pain and temp ipsilateral face, loss on contralateral limbs
Ipsilateral paralysis and deafness - hearing is AICA over PICA
Ataxia, nystagmus
Can get difficulty swallowing
Vestibular schwannoma symptoms
Vertigo, hearing loss, tinnitus
Absent corneal reflex
Associated with NFM 2
Canvernous sinus thrombosis affects
Cranial nerves V1+2
3+4+6
What Ix for MG
Tenilson test
AchR AB
CXR- thymic hyperplasia
What can cause normal pressure hydrocephalus
SAH
Meningitis
Trauma
Types of focal seizures and symptoms
Aware and unaware or evolving into generalised typically tonic clonic
Temporal-hallucinations, lip smacking
Frontal- head movements
Occipital- floaters
Parietal- parasthesia
Symptoms of GBS
Ascending weakness LMN
After GE or STI
Secondary prevention of CVA
Clopidogrel 75mg
Tx of SAH
Coiling
Parkinsonism vs parkinsons
Parkinsonism- symmetrical, rapid, poor response to levadopa
Parkinsons- asymmetrical, progressive, good response
Parksonism
A group of neurological disorders that cause movement problems similar to those seen in Parkinson’s disease such as tremors, slow movement and stiffnes
Parkinson plus syndromes
MSA- autonomic dysfunction- postural hypotension, cerebellar ataxia- falls, ED
Vertical gaze palsy- postural instability falls, speech, dementia
CBD- unilateral parks, aphasia, alien limb
Dementia with LB- hallucinations
Tx of Parkinson’s
Levadopa with dopa decarboxylase
Co-careldopa
Tx of epilepsy
Tonic clonic- valproate, females- lamotrigine or leve
Absence-Ethosuximide
Myoclonic- valproate, female- leve
Tonic/atonic- valproate, female- lamo
Focal- lamo/leve
SE management
ABC
Pre-hospital- PR diazepam/buccal midazolam, hospital IV lorazepam
Second dose after 10-20 mins then phenytoin then ICU after 45 mins
CT head immediately guidelines
FFS
GCS <13
Vomit >1
Fracture of skull
Focal neurological deficit
Seizure
CT head within 8 hours
LOC/amnesis AND
Age >65
Bleeding disorder
Cant remember- Retrograde amnesia >30 mins
Dangerous MOI
Sx of raised ICP
Headache- worse leaning forward
Altered GCS- focal neuro
Cushing response- high BP, low HR, irregular breathing
Papiloedema
Horners syndrome
Miosis
Ptsosis
Anhydrosis
Mx of cauda equina
PO dexa
Decompressive laminectomy
Mx of spinal compression
Dex or surgery
Differentials for headache
Tension- tight band, bilateral
Cluster- around eye
Migraine- aura, throbbing, unilateral
Temporal arteritis- jaw claudication
Med overuse- worse with meds
Types of MND
Amyotrophic Lateral Sclerosis- LMN in arms, UMN in legs
Primary Lateral Sclerosis- UMN
Progressive Muscular Atrophy- LMN distal before- best prognosis
Progressive Bulbar Palsy- palsy of tongue, facial- worst prognosis
Causes of tremor
Parkinsons- stiff, resting
Essential – worse if outstretched, improved by rest and alcohol, FH
CO2 retention- COPD
Cerebellar- intention- with nystagmus, past pointing
Types of MS
Replase-remitting- acute attacks last 1-2m
Primary progressive
Secondary progresive- RR to this, gait and bladder too
Progressive remitting
Sx of MS
TEAM
Tingling
Eye- optic neuritis
Ataxis- other cerebellar- DANISH- dysdiadokinesia, ataxia, nystagmus, intention tremor, slurred speech, hypotonia
Motor- spastic
Warm temps- make worse
Ix of MS
Lp- IgG oligoclonal bands
AB- Anti MBP
Prognostic signs for MS
Good- female, sensory lesions, <25, long intervals in relapse
Mysthenic crisis sx and tx
Reduced RR with MG
Ix- ABG
Mx- plasmapheresis, IVIG, intubation
Ix of MG
Single fibre EMG
Anti-AchR
Mx of MG
Symptomatic- pyridostigmine after diagnosis
Immunosuppress- prednisilone eventually
Thymectomy
UMN signs
Increased tone
Reduced reflexes
Reduced power
Babinski +ve- upgoing plantars
Causes of peripheral neuropathy
Infection
Metabolic- DM, sensory predominant , ETOH sensory then motor
Autoimmune
Vit B12 def
Cerebellar vs vestibular nystagmus
Cerebellar- fast phase towards lesion
Maximal towards
Vestibular- away
Causes of Quadranopia
PITS- parietal inferior, temporal superior
Parietal superior radiation
Temporal- inferior
Causes of bitemporall hemianopia
Pituitary- superior
Craniopharyngioma- inferior
3rd nerve palsy sx
Down and out
Ptosis
Dilated pupil
Wernickes vs Brocas aphasia
Werncikes- receptive
Broca- expressive
Left posterior inferior cerebral artery Sx
Webers syndrome
Contralateral UMN of limbs
Ipsilateral CN3
Cluster headaches Tx
Oxygen
Triptan
Prophylaxis- verapamil
When do you need a CT for pupil sx
If pupil is unreactive to light and dilated
No para- meaning being compressed
Mx of acute MS flare up
IM methyprednisilone
Medical vs surgical 3rd nerve palsy
Medical- ptsosis and abducted
Surgical- dilated due to compression
Idiopathic intracranial hypertension sx
Secondary to impaired drainage
Causes raised ICP
Tinnitus
Affects young obese women
6th nerve palsy
Papiloedema
Change in acuity when changing posture- visual obscuration
Blood supply of Wernickes and Broca area
Wernickes- Inferior left MCA- superior temporal gyrus
Broca- superior left MCA- inferior frontal gyrus
Stroke mx after 4.5 hrs
Aspirin 300mg
Amurosis Fugax
Affects retinal/opthalmic artery
A temporary loss of vision in one or both eyes due to a lack of blood flow to the retin
Degenerative cervical myelopathy sx, dx and mx
Compression of spinal cord in neck
Poor coordination
Pain in neck
loss of sensory and motor
Hoffman sign- flick finger, another fingers twitches
MRI and surgery urgent
Nacolepsy ix
Multiple sleep latency EEG
Bells palsy Mx
10 day course of Pred
If no improvement after 3weeks- urgent referral to ENT
Main Ix of status epilepticus
Rule of hypoxia and hypoglycaemia
BM and ABG
Neuroleptic malignant syndrome sx
pyrexia
muscle rigidity
autonomic lability: typical features include hypertension, tachycardia and tachypnoea
agitated delirium with confusion
Elevated CK
Starts soon after starting new AP
Where touch and proprioception nerves travel
Dorsal columns
Where pain and temp nerves run
Spinothalamic columns
Scale that measures how stroke patients cope with ADLS
Barthel index
Tx of bells palsy
Prednisilone- 3w follow up- no improvement- ENT
Imaging of TIA
Diffuse weighted MR
SAH meds
Nimodipine for vasospasm
Epidural haemorrhage sx
Injury, lucid, LOC
Levadopa SEs
On off effect
Postural hypotension
Arrythmias
Psycosis
Red urine
When shouldn’t you do an LP in meningitis
Sepsis or rash
Bleeding risk
Raised ICp
Tx of brain mets
Dexamethasone
Syringomyelia sx
Fluid cavity- Chiari malformation
Cape like- neck shoulders, arms - loss of temperature and pain- spinothalamic tract - compression of anterior white commissure
Ventral horns- flaccid paralysis
Ix of syringomyelia
MRI spine
Tx of Parkinsons when NBM
Dopamine agonist patch
Pernicious anaemia neuro sc
Peripheral neuropathy- pins and needles
Subacute combined degeneration of spinal cord- progressive weakness
Psychiatric disorder
Sx of Guillain Barre
Ascending
Progressive
Symmetrical
Reflex absent
Sensory- mild
Normal pressure HC sx
Wide gait- ataxia
Urinary symptoms
Cognitive impairment
Wernickes sx
Altered mental state
Ataxic gait
Opthalmoplegia
Korsakoff sx
Wernickes
Plus confabulation and amnesia
Causes of vertigo
Viral labrythitis
Vestibular neuronitis
BPPV
Menieres
Acoustic neruoma
Labrynthitis vs vest neuronitis vs menieres vs BPPV
Recent infection- labry, neuronitis
Lab- hearing loss sometimes, not in neuro
Menieres- fullness- hearing loss, tinnitus
BPPV- short, triggered by head position
Parkinson tx that causes personality changes
Dopamine agonist
Ropinirole
Types of speech disorder
Wernickes- speech fluent, comprehension impaired, repetition imapired
Broca- speech broken
Conduction- link between 2- speech fluent but repetition is poor
Global- affecting all
When are you allowed to stop AED
If seizure free for 2 years
With AEDs stopped 2-3 months
Cerebellar stroke Sx
Ataxia
Nystagmus
Features of cluster headaches
Last 15 min-2 hours
Clusters- 4-12 weeks
Lacrimation, redness
Nasal stuffiness
Factors favouring true seizure over pseudo seizure
Raised prolactin
Tongue biting
Sudden onset
Sx of sinus thrombosis
Headache
N+V
Reduced consciousness
RF of venous thrombosis
Gradual onset
Ix of sinus thrombosis
MRI venography
Usually CT head first
Sign for differentiating between organic and nonorganic lower leg weakness
Hoover sign
Tell them to press down with weak side- will show no affect
Then next flex hip of contralateral (normal) side
If weak side extends (you fell it push down) - non organic
Medication for spasticity in MS
Baclofen or gabapentin
Dx to decrease relapses of MS
Natalizumab
Which drugs should be avoided in MG
AB- gentamicin, macrocodes
Beta blockers
Lithium
Phenytoin