Neural, Muscle, and Fat Tumors Flashcards
3 types of true neuromas
- traumatic
- multiple mucosal
- solitary palisaded encapsulated (PEN)
what is a neurothekoma
what are the two types
nerve sheath myxoma on head and neck
2 types: classic myxoid and cellular
genoderm with myxomas, myxoid neurofibromas
Carney Complex (PRKARA1)
genoderm with psammomatous melanotic schwannoma
Carney Complex (PRKARA1)
aggregates of coarse granules surrounded by a clear zone of cytoplasm in granular cell tumors
pustulo-ovoid body of Milan
virus implicated in merkel cell tumor
polyomavirus
stain to differentiate merkel cell tumor from small cell lung cancer
TTF-1 (neg in MCC), CK20 (pos in MCC)
3 midline nasal lesions
- dermoid cysts
- nasal gliomas (heterotopic brain)
- encephalocele (yes transillumination)
infant w/ firm blue dermal nodules
periorbital ecchymosis (raccoon eyes)
heterochromia of irises
increased catecholamines
infantile neuroblastoma
Ddx small blue cell tumor/blue balls in dermis
LEMONS lymphoma ewing's sarcoma merkel cell & melanoma oat cell carcinoma of lung neuroblastoma small cell endocrine carcinoma
Ddx blueberry muffin baby
- ToRCH infections
- Heme (hemolytic anemia, spherocytosis, ABO incompatibility, twin-twin transfusion, intracranial bleed)
- Malignancy (congenital leukemia cutis, rhabdomyosarcoma, Langerhans cell histiocytosis, neuroblastoma)
genoderms ganglioneuromas
GI = MEN 2B
NF1
start in autonomic nerve cells, can occur anywhere
genoderm with congenital lipomatosis
Proteus syndrome (AKT1)
genoderms with multiple lipomas
- Bannayan-Riley-Ruvalcaba (PTEN)
- Cowden (PTEN)
- Gardner (APC)
- MEN 1 (Menin)
- Frohlich syndrome (lipomas, obesity, sexual infantalism)
- Encephalocraniocutaneous lipomatosis
3 types of leiomyoma
piloleiomyoma, genital leiomyoma, angioleiomyoma
genoderm with multiple leiomyomas
Reed syndrome (fumarate hydratase) uterine leiomyomas, renal cell ca
genoderm with genital leiomyomas
Alport syndrome
X-linked dominant defect in type IV collagen
hematuric nephropathy, deafness, maculopathy
DDx painful tumor
BLEND AN EGG blue rubber bleb leiomyoma eccrine spiradenoma neuroma dermatofibroma angiolipoma neurilemmoma (schwannoma) endometrioma glomus tumor granular cell tumor
Ddx deep tumor
rheumatoid nodule sclerosing lipogranuloma (parrafinoma) giant cell tumor of tendon sheath schwannoma angiolipoma myxoid liposarcoma hibernoma chondroid sarcoma angioleiomyoma nodular fasciitis angioleiomyoma
DDx spindle cells in superficial dermis
SLAM'd against epi Spindle cell SCC (cytokeratin 5 &6) Leiomyosarcoma (actin, desmin) AFX (CD10, CD68, CD99) Melanoma, desmoid (S100)
lymphangiosarcoma in site of chronic lymphedema
Stewart-Treves syndrome
Bazex syndrome
acrokeratosis paraneoplastica violaceous scaling fingers, toes, nose, helices nail dystrophy PPK aerodigestive malignancy
necrolytic migratory erythema
glucagonoma
DM, wt loss, anemia, glossitis
erythema with bulla and light brown papules and scale of face, groin, abdomen
erythema gyratum repens
breast, stomach, bladder, prostate, cervical ca
hypertrichosis lanuginosa acquisita
malignant down
lung, colon, breast
leser-trelat sign
sudden eruptive SKs
stomach ca
paraneoplastic pemphigus
NHL, CLL, Castleman’s
bronchiolitis obliterans complication
exfoliative erythroderma malignancy
lymphoproliferative dz
sweet syndrome malignancy
AML
pityriasis rotunda
hepatocellular ca
tripe palms
w/ AN = GI, w/o AN = lung
cicatricial pemphigoid malignancy
anti-epilegrin (laminin 5)
adenocarcinoma
neurofibromas are composed of what cell types?
schwann cells, perineural cells, mast cells
stain for neurothekoma
NK1C3
soft yellow papules or cerebriform plaques with a wrinkled surface, follow lines of blaschko, buttocks or thigh
nevus lipomatosus superficialis
