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Andrews > Bacterial I - Morgan's Qs > Flashcards

Bacterial I - Morgan's Qs Flashcards

1
Q

CA-MRSA virulence factor

A

panton-valentine leukocidin

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2
Q

If pt is resistant to erythromycin, what other antibiotic should you also check with the D-test

A

clindamycin

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3
Q

name for superficial bacterial folliculitis and MCC

A

Bockhart’s impetigo

MCC: staph aureus

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4
Q

T/F: one way to distinguish sycosis vulgaris from tinea barbae is that it affects the upper lip

A

true: tinea barbae rarely affects upper lip

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5
Q

what are the defects (AD & AR) of Job syndrome? what Ig levels will be elevated and depressed?

A

AD: STAT3 (regulates osteoclast activity)
AR: DOCK8 (seen w/ viral infections)
IgE increases, IgD decreases

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6
Q

what are the defects (XLR & AR) for chronic granulomatous ds

A

XLR: gp91-phox
AR: p67-phox
defect in NADPHX oxidase enzyme complex –> inability to produce respiratory burst –> defective killing of catalase positive organisms

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7
Q

causitive agent in chronic pyogenic paronychia

A

candida

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8
Q

causative agent of abscess formation in pyogenic paronychia? erythema and swelling?

A

abscess formation: staph aureus

erythema & swelling: strep pyogenes

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9
Q

MCC botryomycosis? sinuses discharge?

A

staph aureus

sulfur granules

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10
Q

pyomyositis… MC site in children in tropics? MC site in temperate areas in immunosuppressed?

A

kids in tropics: thigh

immunosuppressed in temperate: deltoid, quad

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11
Q

cause of acute glomerulonephritis in impetigo

A

strep pyogenes M type 2, 49, 55, 57, 60

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12
Q

bullous impetigo site in kids? in adults? what causes extracellular cleavage of Dsg1?
T/F culture is positive for bullae.

A

kids: face and hands
adults: axillae and groin
cleavage of Dsg1: staph aureus exfoliative toxins A & B group 2 phage types 55 & 71
true - culture positive

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13
Q

toxin in SSSS? where do you culture? what do you see in adults? T/F: SSSS affects palms/soles, mucous membranes.

A

toxin: exfoliative toxins A & B group 2 phage types 55 & 71
culture: conjunctiva, nasopharynx, feces, pyogenic foci
adults: immunosuppression, renal ds
false: does not affect palms/soles or mm

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14
Q

cause of staph toxic shock syndrome? acute systemic symptoms?

A

exotoxin TSST-1 superantigen
acute febrile illness with pharyngitis, scarlatiniform exanthem first on trunk, erythema of palms and soles with desquamation

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15
Q

cause of strep toxic shock syndrome? MC initial symptoms?

A

M types 1 & 3 produce exotoxins A, B, C

initial sxs: severe local pain in extremity

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16
Q

toxic shock syndrome superantigen binding site? causes release of what cytokines?

A

binds to V-beta region on T-cells

stimulates T cell release of TNF-alpha, IL-1, IL-6, TLR 2 & 4

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17
Q

T/F: scarlatiniform eruption is more common in strep TSS than staph TSS

A

False

scarlatiniform eruption more common in staph

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18
Q

cause of ecthyma? initial morphology of the lesion? cause in HIV/IVDA pts?

A

cause: strep pyogenes
start as vesiculopustule –> crust –> saucer-sharped ulcer with raw base and elevated edges on shins/dorsal feet
cause in HIV/IVDA: staph aureus

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19
Q

cause of scarlet fever? where does blanchable erythema start?
T/F: the palms and soles peel 2 wks after illness for up to 6 wks

A

cause: strep pyogenes types A, B, & C
neck –> chest & axillae –> trunk –> extremities
true

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20
Q

staph scarlatina refers to?

A

mimic of scarlet fever except no strawberry tongue

21
Q

Job syndrome major findings

A

deficient neutrophil chemotaxis - cold abscesses, cellulitis, carbuncles, eczematous dermatitis, pneumatoceles, bronchitis

22
Q

major findings of chronic granulomatous disease

A

recurrent pyoderma, perioral dermatitis, lymphadenopathy, pneumonia with abscesses, empyema, osteomyelitis (serratia marcescens)

23
Q

Schultz-Carlton phenomenon

A

blanching erythema secondary to exotoxin

24
Q

bacteria that causes scarlatiniform exanthem and pharyngitis in young adults

A

Arcanobacterium haemolyticum

25
Q

cause of erysipelas? lab abnormalities? predisposing factors?

A

strep pyogenes
leukocytosis >20,000
venous insufficiency, lymphedema

26
Q

three types of necrotizing fasciitis

A

I - polymicrobial
II - strep pyogenes
III - clostridial myonecrosis or gas gangrene

27
Q

progression of colors in necrotizing fasciitis

A

red-purple-gray-blue

28
Q

Meleney’s gangrene is a complication of

A

surgical trauma

29
Q

MCC blistering distal dactylitis? can you culture

A 
strep pyogenes (occ staph aureus)
blister fluid of volar fat pad can be cultured
30
Q

cause of perianal dermatitis? in neonates?

A 
strep pyogenes (occ staph aureus)
neonates: group b strep
31
Q

Jones criteria: 2 skin signs and 3 other signs

A

skin: subcutaneous nodules & erythema marginatum
other: polyarthritis, carditis, chorea

32
Q

fish pathogen causing cellulitis of hands

A

strep iniae

33
Q

cause of erysipeloid of Rosenbach

A

erysipelothrix rhusiopathiae

34
Q

erysipeloid purplish swelling of the hands involves the __ but spares the __

A

involves finger webs, spares phalanges

35
Q

pediatric presentation of pneumococcal cellulitis? in IVDA/DM pts?

A

peds: facial and periorbital edema and cellulitis
IVDA/DM: extremity
see fever, leukocytosis, septicemia

36
Q

in anthrax, what inhibits phagocytosis?

T/F: abx therapy does not alter progression from painless carbuncle –> vesicle –> ulcer –> eschar

A

polyclutamic acid capsule

true, progression not altered

37
Q

anthrax exotoxins and affects

A 
edema toxin (edema factor + protective antigen): increases cAMP levels
lethal toxin (lethal factor + protective antigen): release of TNF-alpha and IL1-beta
38
Q

treatment of listeria

A

ampicillin or bactrim

39
Q

name of ulcer caused by corynebacterium diptheria? what must be ruled out before giving IM antitoxin

A

ecthyma dipthericum

must rule out hypersensitivity to horse serum via conjuctival test first

40
Q

3 infections caused by cornyebacterium

A

erythrasma = cornyebacterium minutissimum
pitted keratolysis = kytococcus sedentarius
trichomycosis axillaris = cornyebacterium tenuis

41
Q

what causes coral red fluorescence in erythrasma

A

coproporphyrin III (woods lamp 365 nm)

42
Q

kytococcus sedentarius release __ that destroy the stratum corneum

A

serine proteases K1 and K2 in pitted keratolysis

43
Q

color produced with woods lamp on trichomycosis axillaris

A

pale yellow

44
Q

two membrane toxins produced by clostridium perfringens in gas gangrene? lab abnormalities?

A 
alpha toxin (like sphingomyelinase) and perfringolysin
leukocytosis and hemolytic anemia
45
Q

cause of tropical ulcer/jungle rot

A

bacteroides vincentii

46
Q

cause of desert sore in Australia with grouped vesicles –> rupture into ulcers on shins and knees

A

corynebacterium diphtheriae, staph and strep

47
Q

MC location of actinomyces israelii

A

cervicofacial - lumpy jaw caused by sulfur granules

48
Q

DOC for actinomyces israelii

A

penicillin G

49
Q

T/F: norcardia asteroides is most commonly caused by pulm ds that disseminates. cutaneous form caused by what species? DOC?

A

true
nocardia brasiliensis
bactrim

Andrews (15 decks)

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