Neural Flashcards

1
Q

What occurs when the pressure in the brain presses on the blood vessels? What happens when that pressure continues to rise as blood flow is further impeded?

A

causes blood flow to the brain to slow causing cerebral hypoxa and ischemia

brain may herniate and blood flow ceases all together

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2
Q

What is a primary brain injury? Examples? What is a secondary injury/ Examples?

A

Primary injury: consequence of direct contact to head/brain during the instant of initial injury

Contusions, lacerations, external hematomas, skull fractures, subdural hematomas, concussion, diffuse axonal injury

Secondary injury: damage that evolves over ensuing days and hours after the initial injury

Cerebral edema, ischemia, or chemical changes associated with the trauma

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3
Q

What are signs of a fracture at the base of the skull? (basal fracture)

A

Bleeding from nose pharynx or ears

Battle sign: ecchymosis behind the ear
Halo sign: indicates a CSF leak. Ring of fluid around the blood stain from drainage

Raccoon eyes: bruising into the tissue around the eyes

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4
Q

What are manifestations of increased ICP?

A

Altered level of consciousness, restlessness, irritability
Pupillary abnormalities (a fixed dilated pupil is ominous)
Cranial nerve dysfunction
Sudden onset of neurological deficits and neurological changes; changes in senses, movement, and reflexes
Posturing such as decorticate or decerebrate
Cushing triad – late sign (hypertension, bradycardia, irregular slow RR)
Headache, NV
Seizures

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5
Q

What are the 3 signs of late ICP with Cushing’s triad?

A

hypertension
bradycardia,
irregular slow RR)

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6
Q

What are manifestations of a concussion or mild traumatic brain injury? What is post-concussion syndrome?

A

Change in neurologic function (H/A, dizzy, difficulty concentrating)
No identified brain damage if imaging done
Usually resolves within 72 hrs.

Persistent cognitive and physical manifestations

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7
Q

What are manifestations of a cerebral contusion?

A

Brain is bruised
Forceful injury resulting in bruising of a part of the brain
Can present with decreased LOC,vomiting, confusion
More severe than a concussion
Unconsciousness possible
May lie motionless, faint pulse, shallow breathing, pale skin
Bladder and bowel incontinence
Presents similar to shock (low BP)
Varying outcomes

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8
Q

What is a diffuse axonal brain injury?

A

Widespread shearing injury of axons
Usually from a severe forceful rotational force
Imaging will not reveal the injury
Results in coma

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9
Q

What is a intracranial hemorrhage?

A

Collection of blood in the epidural, subdural, or intracerebral space

Chronic subdural or subacute bleeding; the manifestations are delayed for weeks to mont

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10
Q

What is an epidural hematoma? Manifestations? Is it an emergency? Treatment?

A

Blood collection in the space between the skull and the dura, usually a result from an impact to thetemple area

Client may have a brief loss of consciousness with return of lucid state; then, as hematoma expands, increased ICP will often suddenly reduce LOC

An emergency since arterial bleeding will rapidly expand!

Treatment includes measures to reduce ICP, remove the clot, and stop bleeding
Burr holes or craniotomy, IV mannitol, or 3% N/S
Client will need monitoring and support of vital body functions and respiratory support

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11
Q

What is a subdural hematoma? Who are they commonly seen in? What are manifestations of an acute subdural hematoma? Subacute? Chronic?

A

Collection of blood between the dura and the brain

Common in elderly, especially with use of anticoagulants
Bleeding is from bridging veins that tear easily in elderly clients

Acute: symptoms develop over 24 to 48 hours
Changes in LOC, pupillary signs, hemiparesis, confusion, ataxia

Subacute: symptoms develop over 48 hours to 2 weeks
Requires immediate craniotomy for drainage and control of ICP

Develops over weeks to months
Causative injury may be minor and forgotten
Clinical signs and symptoms may fluctuate
Severe HA, intermittent; alternating focal neurologic signs; personality changes; mental deterioration; focal seizures
Treatment is evacuation of the clot

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12
Q

What is an intracerebral hemorrhage? Causes? Most common cause? Treatment?

A

Hemorrhage occurs into the substance of the brain

May be due to trauma or a nontraumatic cause
HTN, aneurysm, tumors, bleeding disorders, anticoagulant therapy

Most common cause is chronic hypertension

Treatment
Supportive care
Control of ICP
Administration of fluids, electrolytes, and antihypertensive medications
Craniotomy or craniectomy to remove clot and control hemorrhage unless area is inaccessible

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13
Q

What should always be assumed with any traumatic brain injury? Treatment for increased ICP includes what measures? What are the supportive measures?

A

cervical spine injury until ruled out

Adequate oxygenation
Elevating HOB
Maintaining normal blood volume
Drain CSF if needed
Mannitol IV or 3% N/S IV
Hyperventilation with ventilator

Ventilator
Seizure prevention
Fluids and electrolyte maintenance
Nutritional support
Management of pain and anxiety

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14
Q

What is the priority assessment with a brain injury? What other 2 primary assessment should be monitored regularly?

A

ABCDs (priority assessment)
Assess airway, breathing, circulation to ensure oxygenated blood is feeding the brain
Brain injury or death occurs within 3 to 5 minutes of hypoxia
Changes in LOC using the GCS provide the earliest indication of neurologic deterioration

Cranial nerve function
Eye blink response, tongue and shoulder movement
Assess pupils for size, equality, and reaction to light

Bilateral sensory and motor response

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15
Q

What are nursing interventios with head injuries?

A

Maintain c-spine precautions until cleared by x-ray or clinically

Report presence of CSF from the nose or ears to the provider

Monitor fluid, electrolytes, and osmolality to detect changes in sodium regulation (DI or SIADH)

Provide adequate fluids to maintain cerebral perfusion pressure

When giving large amounts of IVF, monitor for fluid overload and cerebral edema

Maintain safety and seizure precautions

Assess/monitor respiratory status, cranial nerve function, and bilateral sensory and motor responses

Support the client’s family- coping can be difficult
If brain death occurs, support the family when deciding whether to donate organs

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16
Q

What are the 3 cardinal signs of brain death?

A

coma
absence of brain stem reflexes
apnea

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17
Q

What is a spinal cord injury? What can be the result of a C-spine injury? T1 or below injury? C4 or above injury?

A

Involve the loss of motor function, sensory function, reflexes, and control of elimination
Level of injury dictates the consequence

C-spine injuries can result in quadriplegia

T1 or below injuries can result in paraplegia

C4 or above injuries can result in impaired ventilation d/t involvement of phrenic nerve

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18
Q

What is primary and secondary SCI?

A

Primary injury is the result of the initial trauma and usually permanent

Secondary injury resulting from SCI include edema and hemorrhage

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19
Q

What constitutes the autonomic nervous system? What can occur with injury to the SC from above T6?

A

Sympathetic chain of nerves is mainlyadjacent to the thoracic spinal cord

Spinal injuries above T-6 can result in neurogenic shock from sympathetic chain injury

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20
Q

What is spinal shock? What is the cause? Manifestations? How long can the loss last?

A

A sudden, but temporary loss of all reflexes and autonomic function below the level of spinal injury

The loss of reflexes, motor and sensation are all directly related to the spinal cord injury not the sympathetic nervous system

Muscular flaccidity and lack of sensation and absent deep tendon reflexes
Loss of sensation below the spinal cord injury level
Paralytic ileus from the loss of autonomic function

Loss of reflexes can last days to weeks, then become hyper-reflexic

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21
Q

What is neurogenic shock? Manifestations? Timeframe? Treatment?

A

Sudden loss of communication within the sympathetic nervous system with a SCI

Blood pressure & heart rate decrease, and cardiac output decreases
Venous pooling occurs due to peripheral vasodilation
Paralyzed portions of the body do not perspire because sympathetic activity is damaged- watch for early detection of fever

Can occur within 24 hours of injury and can last for several weeks

Keeping the mean arterial pressure at least 85 mm Hg can prevent further damage
Administer IV isotonic fluids (N/S or L/R)
Norepinephrine IV may be required

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22
Q

What are nursing actions when treating neurogenic or spinal shock?

A

Spinal shock and neurogenic shock often occur together following a SCI

Stabilize the spinal cord with proper positioning/ immobilizing

Monitor/assess: VS, temp, respiratory status, I&O, neuro status, muscle strength and tone, sensation, GI/GU function, and dependent edema

Treat with appropriate medications (vasopressors such as norepinephrine or atropine to increase HR) and IV fluids

Monitor for skin breakdown and ulcer formation

Client is at greater risk for venous thromboembolism (VTE)
Monitor for manifestations such as leg swelling, areas of warmth and/or tenderness
Administer anticoagulants as prescribed for DVT prophylaxis

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23
Q

What is a common complication of SCI? Cause?

A

orthostatic hypotension

Caused by an interruption in functioning of the autonomic nervous system and pooling of blood in lower extremities when in an upright position

*Change positioning slowly
*Use a reclining wheelchair
*Use thigh-high hose or elastic wraps to increase venous return that may extend all the way up the client’s leg and include the abdomen

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24
Q

What are nursing care actions relating to muscle strength and tone? What type occurs with acute injury? What about later stages? What is the risk in later stages? Treatment?

A

Determine baseline and monitor for increased loss of muscle strength

Encourage active ROM and assist if the client lacks all motor function

Flaccid type of paralysis following acute injury

Spastic muscle tone in later stages
If severe, they can develop pressure injuries

Administer muscle relaxants (baclofen and dantrolene) for severe spasticity
Monitor for drowsiness and muscle weakness

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25
What type of injuries can result in a spastic neurogenic bladder? How is it managed for both males and females? What type of injueris can result in a flaccid neurogenic bladder? How is it managed?
upper neuron injuries in the brain Males use a condom catheter and micturition reflex stimulation (tugging on the pubic hair) Females use an indwelling urinary catheter d/t unpredictable urine release  lower neuron injuries in the spinal nerves Males' and females' interventions include intermittent catheterization and Crede method (downward pressure placed on the bladder to manually express the urine)
26
What are nursing actions to maintain skin integrity when dealing with SCI?
Change position every 2 hours, every 1 hour if in wheelchair Pressure ulcers can develop within 6 hours Monitor Cervical collars- skin breakdown under chin, on the shoulders, and at the occiput Use pressure relief devices continuously
27
What is autonomic dysreflexia? Triggers? Why is it an acute emergency? What types of SCI can result in this complication?
An abnormal, overreaction of the involuntary (autonomic) nervous system to a stimulus The stimulus causes an overreaction by the injured sympathetic system and an attempt to compensate by the parasympathetic system Sympathetic stimulation is usually caused by a triggering stimulus in the lower part of the body Distended bladder MOST COMMON CAUSE CHECK PATENCY OF FOLEY CATHETER Distention or contraction of visceral organs Such as constipation Stimulation of the skin by a compressive dressing or a skin infection because of the resulting extreme hypertension SC lesion above T6
28
What are symptoms of autonomic dysreflexia?
Extreme hypertension Severe pounding headache- Why? What is the risk? Pallor below the level of SC lesion’s dermatome Flushing and profuse diaphoresis above the spinal level of lesion Blurred vision Restlessness Nausea Nasal congestion Bradycardia
29
What are nursing action for autonomic dysreflexia?
Place client in sitting position immediately- this is priority! Notify the healthcare provider Determine and treat the cause Check patency of urinary catheter or insert catheter for distended bladder Remove fecal impaction Assess for injury (skin, fractures, infection) Remove tight clothing Adjust room temperature and block drafts Monitor VS Administer antihypertensives (nitrates or hydralazine) 
30
What is a halo traction/cervical tong? Nursing actions?
Provides traction and or immobilizes the spinal column Nursing actions Maintain body alignment and ensure weights hang freely Monitor skin integrity- assessing under the vest Provide pin care Do not use the device to turn or move the client Good skin care- dry, no powder Teach vest care- liner should not get wet, liner should be changed periodically
31
What is a decompressive laminectomy? Nursing actions?
Decompressive laminectomy removes a section of lamina, removes bone fragments, foreign bodies, or hematomas that can place pressure on the cord Donor bone is often obtained from the iliac crest and is used to fuse the vertebrae together Paravertebral rods are used to immobilize several vertebral levels  Assess for airway compromise from swelling or hemorrhage with cervical fusions Assess neurological status and VS every hour the first 4 hrs. post op
32
What is menigitis? What are the 3 types and common conditions that cause them?
Inflammation/infection of the meninges which cover brain and spinal cord Types  Bacterial- a contagious infection with a high mortality rate Otitis media, sinusitis can spread to meninges Viral- the most common form that usually resolves without treatment Measles, mumps, herpes, West Nile virus Fungal meningitis is common with AIDS or immunosuppression Cryptococcus neoformans 
33
What are the 3 vaccines that help to prevent meningitis?
Hemophilus influenzae type b (Hib) Infants, 4 doses starting at 2 months of age Pneumococcal polysaccharide vaccine (PPSV) Also intended to prevent respiratory infections For adults who are at risk (immunosuppressed or crowded living conditions) Meningococcal vaccine (MCV4) Adolescents prior to living in a college dorm or military base Recommended at age 11 or 12 with a booster at age 16
34
What are the manifestations of meningitis?
Excruciating, constant headache Nuchal rigidity (stiff neck) Altered level of consciousness Positive Kernig sign- thigh flexed on abdomen, can’t fully extend Positive Brudzinski sign- with neck flexed, flexion of knees and hips is produced Fever and chills Nausea and vomiting Behavioral changes Photophobia Hyperactive deep tendon reflexes Tachycardia Seizures Red macular rash (petechiae) Restlessness, irritability
35
How is meningitis accurately diagnosed? What does the appearance of spinal fluid indicate? What will labs indicate?
lumbar puncture Cloudy: bacterial Clear: viral Elevated WBC Elevated protein Decreased glucose: bacterial Elevated CSF pressure
36
What are isolation precaustions for meningits?
Isolate the client as soon as meningitis is suspected! Droplet precautions Continue precautions until antibiotics have been administered for 24 hrs. and secretions are no longer infectious. Those with bacterial meningitis may need precautions continuously. Follow hospital policy.
37
What are nursing actions when treating meningitis?
Monitor VS and assess for septic shock Implement fever-reduction measures Bedrest with HOB at 30° Monitor for increased ICP. Avoid increasing ICP Seizure precautions Provide a calm and quite environment with dim lights Report meningococcal infections to the public health department
38
What are meds used with meningitis?
Ceftriaxone or cefotaxime in combination with vancomycin Given until C&S results are available Early administration of high doses of appropriate IV antibiotics for bacterial meningitis Phenytoin Anticonvulsant if ICP increases or the client has a seizure Acetaminophen, ibuprofen Analgesic for HA and/or fever Prefer nonopioids to avoid masking changes of LOC Prophylactic antibiotics (ciprofloxacin, rifampin) for those in close contact with the client
39
What are complications related to meningitis?
Increased ICP Leads to brain herniation and death Monitor signs of increased ICP and treat with mannitol SIADH Monitor blood and urine labs (serum Na, and urine specific gravity) Provide interventions such as demeclocycline and restrict fluids Daily weights Septic emboli Can occur in the hands and feet Lead to gangrene and DIC
40
What is a brain abscess? Who is at riak? Prevention? Diagnostics?
Collection of infectious material within brain tissue Risk is increased in immunocompromised clients  Prevent by treating otitis media, mastoiditis, sinusitis, dental infections, and systemic infections promptly Diagnosis by MRI or CT CT-guided aspiration is used to identify the causative organisms
41
What are S/S of a brain abscess? Managment? Nursing care?
Headache that is usually worse in the morning Fever Vomiting Neurologic deficits- weakness, decreasing vision Signs and symptoms of increased ICP- decreasing LOC and seizures Control ICP Drain abscess Antibiotic therapy Treat cerebral edema- corticosteroids Conduct frequent and ongoing neurologic assessment and responses to treatment Ensure client safety and protect from injury Provide supportive care Monitor for neurologic deficits
42
What is encephalitis? Causes? S/S? Medical management? Nursing care?
Acute, inflammatory process of the brain tissue Causes Viral infections HSV West Nile St. Louis Fungal infections Headache Fever Confusion Changes in LOC Vector-borne rash Flaccid paralysis Parkinson-like movements Acyclovir for HSV infection Amphotericin B and/or other antifungal agent for fungal infection Control seizures Control ICP Frequent and ongoing assessment  Dim lights Limit noise PRN pain meds Use cautiously- may mask neuro symptoms Monitor intake and output- be alert for presence of renal complications from antiviral therapy Monitor for seizures
43
What is MS? Where are the most common locations of damage?
A chronic progressive immune-related demyelination disease of the CNS Demyelination interrupts the flow of nerve impulses Plaques can occur on axons Unable to regenerate and causing irreversible damage Most common areas include optic nerve, cerebrum, brainstem, cerebellum, and spinal cord
44
What are S/S of MS?
Fatigue Weakness Numbness Difficulty in coordination Loss of balance Pain or paresthesia Visual disturbances Difficulty with speech Muscle spasticity Bowel and bladder dysfunction Cognitive dysfunction Sexual dysfunction
45
What is nursing care with MS?
Monitor the following Visual acuity Speech patterns Swallowing Activity intolerance Skin integrity Urinary incontinence Discuss coping mechanisms and resources Encourage fluid intake and other measures to decrease the risk of UTI Assist with bladder elimination Establish a voiding time schedule Every 1.5 to 2 hours Monitor cognitive changes Plan interventions to promote cognitive function Reorient as needed, place objects used in routine places Use a communication board as needed Apply eye patches to treat diplopia Alternate eyes every few hours Teach scanning technique Exercise and stretch affected muscles Balance activity and rest Maintain a safe environment- fall risk! Walk with feet apart- widen base of support Watch the feet while walking
46
What are meds used with MS, MOA and AEs?
Interferons beta-1a and beta-1b (injections) Start early in the course of disease Used to prevent and treat relapses Adverse effects: flu-like symptoms  Corticosteroids (prednisone, dexamethasone, methylprednisolone) Reduce inflammation in acute exacerbations (very high doses used) Adverse effects: infection, hypervolemia, hypernatremia, hypokalemia, hyperglycemia, GI bleeding, and personality changes, insomnia, weight gain Antispasmodics (dantrolene, baclofen, diazepam) for muscle spasticity Anticonvulsants (carbamazepine, gabapentin, pregabalin) is used to treat paresthesia Anticholinergics (oxybutynin, tolterodine) is used for bladder dysfunction
47
What is myasthenia gravis?
Impaired transmission of impulses across the neuromuscular junction Loss of acetylcholine receptors on muscles due to autoimmune destruction Considered a motor disorder- varying degrees of weakness of the voluntary muscles
48
What are S/S of myasthenia gravis? Most concerning symptom?
Symptoms frequently occur in the face Diplopia Ptosis Weakness of facial muscles Dysphonia- caused my laryngeal involvement Dysphagia- increased choking and aspiration Generalized weakness- affects extremities, intercostal muscles which leads to respiratory failure Most concerning symptom with a new diagnosis is shortness of breath, or increasing work of breathing from respiratory muscle weakness
49
What is medical management of myasthenia gravis?
Pharmacologic Therapy: (2 parts to medication treatment) Anticholinesterase meds- inhibits breakdown of acetylcholine (pyridostigmine) Immunosuppressant meds: an autoimmune disease (azathioprine, cyclosporine) Therapeutic Plasma Exchange (Plasmapheresis) Exchange of plasma Reduces the number of antibodies circulating in the bloodstream Temporary relief from symptoms- few weeks Surgery Thymectomy- removal produces antigen-specific immunosuppression and clinical improvement Frequently done to control myasthenia gravis long-term
50
What is nursing care with myesthenia gravis?
Medication management- understanding actions of meds and schedule of taking them Conservation of energy- identify times of rest throughout the day Risk of aspiration- meals should coincide with peak effects of anticholinesterase meds Impaired vision- tape eyes closed for short periods, artificial tears, eye patches Avoid factors that exacerbate symptoms- emotional stress, infections, rigorous activity, heat Support groups
51
What is a myasthenic crisis relating to MG?
Result of disease exacerbation or a precipitating event, most commonly a respiratory infection THE COMMON COLD!!! Severe generalized muscle weakness with respiratory distress or failure Monitor for any shortness of breath, tachypnea, or increased work of breathing Client is admitted to ICU and closely monitored
52
Whatis guillain barre syndrome? S/S
Autoimmune disorder with acute attack of peripheral nerve myelin sheath Rapid demyelination of peripheral nerves starting in legs and arms Ascending weakness  May produce respiratory failure and autonomic nervous system dysfunction with CV instability (changes in BP, HR) Most often follows a viral infection Muscle weakness Muscle paralysis Paresthesias Pain Diminished or absent reflexes that start in the lower extremities and progress upward Cranial nerve syndromes (peripheral nerves) Changes in vital signs- vagus nerve affected- tachycardia, bradycardia, hypertension, orthostatic hypotension  
53
What causes bells palsy? manifestation? What is the diffence in manifestations of bells palsy and a stroke?
Facial paralysis caused by unilateral inflammation of the seventh cranial nerve unilateral facial muscle weakness or paralysis with facial distortion, decreased lacrimation, and painful sensations in the face; may have difficulty with speech and eating due to weak muscles, increased sound sensitivity, loss of taste to affected side, increased tearing (loss from eye leading to dry eye), and decreased saliva production bells palsy includes forehead, stroke does not
54
What are diagnostic measures for brain tumors? What are risks and benefits of a biopsy?
CT, MRI, PET scan, cerebral angiogram Determines size, location and extent of the tumor Cerebral biopsy Usually guided by CT or MRI scan Abnormal cerebral tissue is sent to pathology Benefits-minimally disruptive to the rest of the brain, decreased recovery time, and not associated with risk of an open craniotomy Negative- does not remove or debulk the tumor, results can be inconclusive, and possible misdiagnosis
55
What are brain tumor meds and managment?
Non-opioid analgesics Avoid opioids as they can decrease LOC Corticosteroids (dexamethasone) Reduce cerebral edema Relieves headaches, improves LOC Osmotic diuretics (mannitol) Decrease fluid content of the brain Decreases ICP Anticonvulsant medication (phenytoin) Control and prevent seizures H2-antagonist (famotidine) Decreases the risk of stress ulcers Antiemetics (ondansetron) Radiation/chemotherapy Craniotomy (if surgery is possible)
56
What is parkinsin's disease?
Slowly progressing and debilitating disorder of movement Decreased levels of dopamine which allows acetylcholine to dominate in substantia nigra
57
What are assessment findings of parkinson's?
Four primary findings Tremor/pill-rolling tremor of fingers Muscle rigidity Bradykinesia Postural instability/stooped posture Fatigue Slow, monotonous speech Masklike facial expression Difficulty chewing and swallowing Drooling Dysarthria Mood swings Cognitive impairment/dementia (late) Autonomic findings Orthostatic hypotension Flushing Diaphoresis
58
What are the 2 main meds and MOAs for parkinson's? Signs of toxicity?
Levodopa (dopaminergic) is converted to dopamine in the brain Carbidopa protects levodopa from being metabolized before it reaches the brain Allows for smaller doses and less adverse effects Muscle twitching Facial grimacing Spasmodic eye winking
59
What are other med treatmens for parkinson's? AEs?
Dopamine agonists (pramipexole) Combine with dopaminergic for better results Adverse effects: orthostatic hypotension, dyskinesias, and hallucinations Anticholinergics (benztropine) Decrease tremors and rigidity Adverse effects: anticholinergic effects  COMT inhibitors (entacapone) Decrease the breakdown of levodopa Adverse effects: dark urine, diarrhea MAO-B inhibitors (selegiline) Reduce the wearing off phenomenon Avoid foods high in tyramine- can cause hypertensive crisis
60
What are therapeutic procedures for parkinson's?
Stereotactic pallidotomy or thalamotomy When clients are unresponsive to other therapies Causes destruction of a small portion of the brain Deep brain stimulation Electrode is implanted in the thalamus Current is delivered through a small pulse generator implanted under the skin of the upper chest Decreases tremors and involuntary movements
61
What is Huntington's disease? Pathology? S/S?
A chronic progressive hereditary (autosomal dominant) disease that results in choreiform movement and dementia Pathology involves premature death of cells in the striatum of the basal ganglia (control of movement) and the cortex (thinking, memory, perception, judgment) Occurs at midlife (30-50) Chorea Intellectual decline Emotional disturbance Uncontrollable movement Tics and grimaces Speech problems- slurred, hesitant, explosive Dysphagia- risk for aspiration Disturbed gait with eventual bedrest Impaired judgment and memory Anger, dementia, and psychosis eventually ensue
62
What are the 3 stages of alzheimer's?
Three general stages   Mild Alzheimer  Stages 1-3 Moderate Alzheimer Stages 4 and 5 Severe Alzheimer  Stages 6 and 7
63
What are pharmaceutical management of AD?
Antipsychotics Antidepressants Anxiolytics  AD Medications may temporarily improve activities of daily living Donepezil prevents the breakdown of acetylcholine Memantine blocks nerve cell damage caused by excess glutamate  Adverse effects: frequent stools, upset stomach, and dizziness/headache, unsteady gait
64
What is ALS?
amyotropic lateral sclerosis (Lou Gehrig) Unknown cause Progressive illness Loss of motor neurons in the anterior horn of the spinal cord and loss of motor nuclei of the lower brainstem Occurs most between 40 and 60 years of age
65
What are S/S of ALS?
Fatigue Progressive muscle weakness Cramps Fasciculations (twitching) Incoordination Difficulty in talking Difficulty in swallowing Difficulty in breathing
66
What is the patho of muscular dystrophies?
Incurable disorders characterized by progressive weakening and wasting of skeletal and voluntary muscles Most are inherited disorders Muscle tissue is replaced with connective tissue
67
How do disc herniations manifest? Medical managment? Nursing care?
Cervical disc herniation (cervical radiculopathy) Lumbar disc herniation (sciatica) Spondylosis- degenerative changes in disc and adjacent vertebral bodies Paresthesia- numbness, tingling, pins & needles Pain and stiffness in the neck and shoulders Low back pain, especially with activity Postural deformity Medications- analgesics, NSAIDs, muscle relaxers, corticosteroids Surgery- discectomy with or without fusion Nursing Management Relief of pain Improve mobility Monitor for bleeding / hematoma (following surgery) Frequent neuro checks- spinal cord compression may produce rapid or delayed onset of paralysis Monitor for dysphagia- anterior approach cervical surgery
68
What is client positioning with disc herniation?
side-lying with pillow between legs supine with pillow under lower legs
69
What is the CNS? PNS? ANS?
Central nervous system Brain and spinal cord Peripheral nervous system Includes cranial and spinal somatic nerves (motor and sensory) and the Autonomic nervous system
70
What is the ANS? Sympathetic? parasympathetic? what regulates these systems?
Functions to regulate activities of internal organs and to maintain and restore internal homeostasis Sympathetic nervous system “Fight or flight” responses   Main neurotransmitter is norepinephrine  Sympathetic division is mainly from the thoracic sympathetic ganglion Parasympathetic nervous system "Rest and digest" responses Controls mostly visceral functions Parasympathetic division is mainly from cranial nerves and sacral nerves Regulated by centers in the spinal cord, brainstem, and hypothalamus
71
A neurologic assessment is assessing the health history of what manifestations? It includes assessment of what systems?
Pain Seizures Ataxia (abnormal balance or movement) and vertigo (illusion of movement, usually rotation) Visual disturbances Weakness  Abnormal sensations Past health, family, social history Consciousness and cognition Cranial nerves Motor system Sensory system Reflexes
72
What are the cranial nerves? Mneumonic?
1 olfactory 2 optic 3 oculomotor 4 trochlear 5 trigeminal 6 abducens 7 facial 8 vestibulocochlear 9 glossopharyngeal 10 vagus 11 accessory 12 hypoglossal Some Say Marry Money, But My Brother Says Big Boobs Matter Most
73
Where does the spinal cord end?
T12-L1
74
What are concerns for CT contrast administration?
Allergies to shellfish/iodine Assess BUN and Cr NPO 4 hours prior for contrast Monitor for allergic reaction Flushing out contrast by increasing PO fluids Stop metformin prior to IV contrast
75
What is a PET scan and a SPECT? What do they do? How is this accomplished?
positron emission tomography single photon emission computed tomography Both are nuclear imaging exams Produce 3D images of static (depicting vessels) or functional (brain activity) Determines tumor activity and/or response to treatment Determines dementia (the brain does not respond to the tracer) Both use radiation PET Glucose-based tracer is injected into the blood stream prior  initiates regional metabolic activity  documented by PET scanner SPECT Uses a radioisotope to initiate metabolic activity
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What is MRI? What does it do and by what means? What can it identify?
magnetic resonance imaging Cross sectional images Images are obtained using magnets (not radiation) Safe for pregnancy  Not compatible with some artificial devices (pacemakers, surgical clips, any metallic objects) Use MRI-approved equipment to obtain VS and provide ventilation/oxygen Done with or without contrast Capable of discriminating soft tissue from tumor or bone Determine tumor size and blood vessel location 
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What is cerebral angiography? What does is assess? What can is be used for? Nursing actions?
Looks at circulation to the brain with a contrast agent Assesses narrowing of vessels, aneurysms, strokes, vascularity of tumors Used to inject medications to treat blood clots or administer chemo Contrast agent is injected into the femoral or carotid artery Nursing Actions NPO 4 to 6 hours prior Assess BUN and Cr Determine history or bleeding or anticoagulant use Hydrate before procedure Void immediately before procedure Mild sedation for relaxation can be used Warmth in face, behind eyes or in mouth, and metallic taste with dye injection Frequent neuro checks after the exam (embolism/arterial dissection) Assess puncture site (bleeding/hematoma) and circulation  Activity restriction  Ice pack to insertion site
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What is an EEG? What does it do?
electroencephalography A non-invasive test  Assesses the electrical activity of the brain  Most done to assess for seizure disorders  Also used to evaluate sleeping disorders and behavioral changes Used to determine brain death
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What is pre, intra, post nursing procedures with an EEG?
Preprocedural Review medications Client education: wash hair, stay awake the night before the test (to achieve sleep-deprivation which can induce a seizure), during the exam you might be exposed to flashing lights or asked to hyperventilate for 3-4 minutes, and avoid sedating or stimulant medications 24 hrs. prior  Intraprocedural Procedure takes 45 to 120 minutes Small electrodes are placed on the scalp Notations are made when stimuli is present Postprocedural Resume normal activities
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What is the location of a lumbar puncture? What are its therapeutic uses? What are some results from CSF analysis and what could they potentially indicate?
Spinal tap- L3/L4, L4/L5 as spinal cord ends L1, small amount of CSF is removed Can determine disease processes (MS, meningitis, syphilis) Also used to reduce ICP by removing fluid, instill contrast media for imaging, or administer chemotherapy directly to central nervous system for malignancies Obtain CSF samples for analysis  Clear vs. pink-tinged (bleeding in brain) Cell count (WBC elevated with inflammation/infection) Culture (viral cultures for encephalitis, bacterial cultures for meningitis) Glucose (reduced with bacterial infection) Protein (elevated with MS, Guillain-Barre syndrome, and infections)
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How long should client be flat after a limbar puncture? what are possible complications?
4-8 hrs Brain herniation due to removal of fluid with high ICP Spinal hematoma  compression of cauda equina and paralysis Infection introduction of the spinal canal Post- LP headaches 
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How is the Glasgow coma scale measured?
 Eye opening 4 spontaneous 3 to sound 2 to pain 1 none verbal 5 coherent and oriented 4 incoherent and disoriented 3 makes no sense 2 sounds, not words 1 none motor 6 follows commands 5 local reaction to pain 4 withdraws from pain 3 decorticate posture 2 decerebrate posture 1 none
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What is decorticate posturing? Think core
elbows flexed on chest, arms adducted to sides, legs internally rotated, feet flexed
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What is decerebrate posturing?
arms adducted and extended, hand flexed, feet flexed
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What is the normal intracranial pressure range?
10-15 mmHg
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What does the HTN component of cushing triad look like?
systolic increased diastolic decreased
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What is cerebral perfusion pressure? Equation? Normal range? Range of brain damage?
CPP is closely linked to ICP CPP is determined by mean arterial pressure minus intracranial pressure Provides an estimation of the blood pressure that allows blood to flow to brain CPP = MAP – ICP Normal CPP is 70 to 100 mm Hg A CPP of less than 50 results in permanent damage
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What are nursong acctions with a craniotomy?
Administer mannitol and dexamethasone every 6 hrs. for 24 to 72 hrs. post-op to reduce ICP and cerebral edema Administer phenytoin or diazepam to prevent seizure activity  Monitor ICP  Supratentorial surgery  Maintain HOB of at least 30° with proper body positioning to prevent increased ICP Infratentorial  Keep client flat and on either side for 24 to 48 hrs. to prevent pressure on the neck incision site  Maintain a calm environment  Provide emotional support (brain surgery is an extremely fearful procedure)
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What are 5 types of seizures?
Tonic-clonic seizure Breathing can stop, cyanosis, biting, incontinence Period of confusion and sleepiness follows the seizure  Tonic seizure Sudden increased muscle tone, loss of consciousness, and autonomic manifestations (vomiting, incontinence, salivation) Clonic seizure Muscles contract and relax, can last several minutes Myoclonic seizure Brief jerking or stiffening of the extremities for few seconds  Atonic or akinetic seizure Muscle tone is lost, clients frequently fall Confusion follows the seizure
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What is a partial or focal seizure? What are the 2 types and how do they manifest?
Involves only one side of the hemisphere Two types Simple partial  Consciousness is maintained Can cause unusual auras as well (sense of déjà vu, offensive smell) Results in focal symptoms such as movement of an arm or leg Complex partial Associated with automatisms (unaware of lip smacking or picking at clothes) Can cause a loss of consciousness or black out for several minutes Amnesia can occur immediately before and after 
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What are risk factors for seizures?
Genetic predisposition Cerebrovascular disease Hypoxemia Fever (childhood) Head injury Cerebral edema Hypertension Central nervous system infections like encephalitis or meningitis Metabolic (hypoglycemia or hyponatremia) Brain tumor Drug and alcohol withdrawal Allergies Abrupt cessation of antiepileptic drugs Toxins Stroke Heart disease Fluid and electrolyte imbalances
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What is status epilepticus? Causes? Complications? Treatment?
Repeated seizure activity within a 30-min time frame without full recovery or a single, prolonged seizure lasting more than 5 minutes (ATI, 2023) Medical emergency to stop the seizure (prevent hypoxemia/ischemia to brain) Usual causes ETOH withdrawal, sudden withdrawal from antiepileptic drugs, head injury, cerebral edema, infection, metabolic disturbances Complications Decreased oxygen levels, inability to return to normal functioning, and continued assault on neuronal tissue Treatment ABC, oxygen, IV access, ECG, and O2 sat monitoring IV/IM diazepam or lorazepam followed by IV phenytoin infusion
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What are the stages of a migraine with aura (classic migraine)
Prodromal phase- awareness of symptoms before onset of headache (irritability, depression, food cravings, diarrhea, constipation, frequent urination); often hours to days prior to headache Aura stage- numbness/tingling, confusion, visual disturbances; minutes to hours prior to headache. Can be confused with a stroke due to initial neurological symptoms Second stage- severe throbbing headache that intensifies over several hours, NVD, vertigo, photophobic, and phonophobia Third stage- dull headache that lasts 4 to 72 hrs. Recovery- with pain and aura subsiding, muscles ache, physical activity worsens pain
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What is pharm treatment for mild migraines? Severe?
NSAIDs (ibuprofen, naproxen) or acetaminophen products Antiemetics such as metoclopramide or ondansetron Triptans (sumatriptan) Cause vasoconstriction to treat the migraine HA Educate the client to notify the provider for continuous or severe chest pain Contraindicated for those who have a history or are at risk for MI Ergot alkaloids (ergotamine) Cause powerful vasoconstriction to control migraine HA Can cause hypertension, chest pain, and ischemia to fingers and toes Adverse effects: GI discomfort with nausea and vomiting Toxicity: paresthesia in fingers and toes, peripheral ischemia  Not for long-term use to avoid physical dependence  Pregnancy category X
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What is a TIA? How long does it last? What is it indicated could happen
transient ischemic attack Temporary neurologic deficit resulting from a temporary impairment of blood flow All neurological function returns to normal, usually within minutes to hours “Warning of an impending stroke” in the future
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What are the FAST signs of a stroke?
Facial drooping (ask client to smile—look for unilateral facial drooping.) Arm weakness (ask client to raise both arms—look for downward drift.) Speech impairment or difficulty speaking (ask client to repeat a simple phrase—listen for unexpected findings such as slurred speech.) Time to call 911 (if any of above findings present, call 911 immediately.)
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What are the 2 types of stroke?
Ischemic Decreased oxygenation to the brain r/t vascular occlusion from thrombotic or embolic event Thrombotic stroke: Occurs secondary to a blood clot on an atherosclerotic plaque Embolic stroke: Caused by embolus traveling from another part of the body to a cerebral artery such as atrial fibrillation Hemorrhagic Bleeding into the brain from a ruptured artery or aneurysm  Main risk factor is chronic hypertension Poorer prognosis Significant ischemia and increased ICP
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What is the left cerebral hemisphere responsible for? What are manifestations of a LH stroke?
responsible for language, mathematics skills, and analytical thinking Expressive or receptive aphasia (inability to speak or understand language) Agnosia (unable to recognize familiar objects) Alexia (reading difficulty) Agraphia (writing difficulty) Right hemiplegia (paralysis) and hemiparesis (weakness) Hemianopsia (loss of visual field) Slow, cautious behavior Depression, anger, and quick to become frustrated
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What is the right cerebral hemisphere responsible for? What are manifestations of a RH stroke?
Responsible for visual and spatial awareness and proprioception Altered perception of deficits Unilateral neglect syndrome (more common in R) Loss of depth perception Poor impulse control and judgment Left hemiplegia or hemiparesis Hemianopsia
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What are diagnostic procedure in the event of a stroke?
Coagulation panel: PT/INR/aPTT prior to initiating fibrinolytic or anticoagulation medications 12 lead ECG Doppler ultrasound: (carotid) to determine perfusion to the brain, check for occlusions or blockage Non-contrast CT scan: Used emergently to assess for strokes Perform within 25 minutes of arrival to the ED! Used to determine the type of stroke (ischemic or hemorrhagic) and whether the client is a candidate for thrombotic therapy (t-PA) Cerebral Angiography:  Outlines the entire vascular tree to the brain A cerebral CTA is often used (combination of a CT with angiography) MRI: Can identify edema, ischemia, and necrosis Not used emergently since a much longer test to perform GCS: to assess and follow the level of consciousness (LOC) with acute stroke Dysphagia screening: Speech-language pathologist can perform a swallowing study
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What is treatment for an ischemic sroke?
Early treatment is important (time is brain tissue) Thrombolytic therapy (also known as fibrinolytic therapy) if appropriate Tissue plasminogen activator (t-PA) Administer within 3 to 4.5 hours of initial manifestations Only given for ischemic strokes
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What are therapeutic procedures for ischemic strokes?
Thrombectomy (Intra-arterial t-PA administration): Directly infuses t-PA into occluded artery to dissolve the clot Endovascular therapy: With a guidewire system, the clot is removed from occluded artery Carotid artery angioplasty with stenting (CAS) Stent is placed to open a blockage  Performed within 6 hours of onset of manifestations Carotid endarterectomy (if occluded carotid artery) Removes atherosclerotic plaque in the carotid artery
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What are nursing actions with strokes?
Monitor VS every 1 to 2 hours Monitor LOC and treat fever which can increase ICP (increase metabolic demands of brain) Maintain SpO2 >92% if the client has a decreased LOC Monitor ECG for cardiac dysrhythmias Conduct a cardiac assessment to detect murmurs and irregularity Monitor for hyperglycemia which is associated with poor neurologic outcomes Elevate HOB to at least 30°, prevent extreme flexion/extension of head Institute seizure precautions
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What is homonymous hemianopsia? Client instructions?
decreased visual field Instruct the client to use a scanning technique when eating and ambulating Put items in the room within the client’s view
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What is the normal CPP? What is the formula to calculate CPP? What would decrease the CPP?
cerebral perfusion pressure 70-100 mmHg MAP - ICP = CPP a low MAP or high ICP
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What are early manifestations of elevated ICP?
changes in LOC restlessness, agitation, confusion weakness in one side drowsiness HA increasing in intensity
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What are the late manifestations of elevated ICP?
respiratory and vasomotor changes projectile vomiting dixed dilated pupils seizure coma posturing changes in VS, Cushing's triad
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What incidental circumstances that can elevate the ICP? Nursing actions?
increased CO2 suctioning coughing/straining neck/hip flexion or extenaion laying flat, bed less than 30 degrees constrictive clothing Valsalva maneuver HOB 30-45 degrees keep head and neck still ventilation prevent constipation
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How are seizures aggravated when being monitored with an EEG?
sleep deprivation flashing lights hyperventilation
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What med is given IV to stop a seizure? If client is on seizure precautions what should be done ahead of time?
benzodiazepine followed by phenytoin IV access in the event of a seizure
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