Nervous System IV Flashcards
Nerve Impulse Direction
Impulse travels forward along the axon because the previous segment is still in it’s refractory period
Acetylcholine
Neurotransmitter at the neuro muscular junction. Little chemical that moves across the synapse to bind to the acceptor.
Example of a NT (chemical messenger that bridges the synapse)
Acetylcholinesterase
An enzyme that breaks down acetylcholine in the synaptic cleft so depolarization is not a continuous event.
Excitatory Post Synaptic Potential (EPSP)
Graded depolarization of post synaptic membrane by the arrival of a NT.
Inhibitory Post Synaptic Potential
makes a postsynaptic neuron less likely to generate an action potential
Ex: GABA
GABA
Binds to Potassium Gate
Catecholamines
Also a neurotransmitter. Work with a secondary messenger to depolarize membrane.
Ex: Epinephrine, norepinephrine, dopamine
Depolarization with a Secondary Messenger
- Action potential depolarizes synaptic knob
- Calcium enters axoplasm triggering norepinephrine release into synaptic cleft (1st messenger)
- norepinephrine binds to receptor site causing AC (Adenyl Cyclase) with in cytoplasm to catalyze formation of cyclic AMP from ATP
- cyclic AMP (2nd messenger) opens ion channels allowing sodium to depolarize membrane
Summation
Integration of EPSP’s and IPSP’s to reach depolarization threshold.
How much mV will EPSP produce local depolarization?
.5 mV when action potential may require -15 to -20 mV charge to reach depolarization threshold.
Two ways for EPSP to Reach Depolarization Threshold?
Temporal Summation and Spatial Summation
Temporal Summation
Same location, different time - a stimuli occurring in rapid succession at the same synaptic knob. Close enough together to eventually reach summation.
Spatial Summation
Same time, different location - stimuli arriving at the same time at different locations in loose proximity. Enough local depolarization.
Adaptation
Reduction of sensitivity in the constant presence of a stimulus. In general our body gets use to it.
Neural Interaction
Patterns of neuronal interaction