Nervous system Flashcards
Myelin is produced in the CNS by?
olygodendrocytes
Myelin is produced in the PNS by?
schwann cells
glia cells role?
support and structure
Astrocytes
- from ectoderm
- Nourish neurons; form blood-brain barrier; homeostasis of ions; clear out synapses
Ependymal cells
Line brain ventricles; produce CSF
Ependymal cells help form the barrier that holds in and produces CSF, cerebrospinal fluid.
Microglia
- from mesoderm from monocytes (NOT ECTODERM)
- Phagocytic cells of CNS; immune function; antigen presentation
Oligodendrocytes /Schwann cells
- ectoderm
- Produce myelin in CNS and PNS
What is the Resting potential and how is it maintained?
-70mV, ATPase –> 3Na+ out and 2K+ in and gradient
Action potential production
- the ATPase maintains high Na outside and high K inside
- when the neuron receives a presynapse, causes depolarization: at threshold of depolarization, Na channels open to let Na in then close at -35mV (absolute refractory period)
- repolarization: K channels open to let K out to then close but cell is in state of
- hyperpolarization: too many K out. to prevent further action potential
- stabilized back to -70mV with ATPase
What is the threshold for depolarization?
- 55 mV
temporal summation
multiple presyn received by neurons, and integrated in a short amount of time
spacial summation
additive effects based on number and location of the incoming signals
absolute vs relative refractory period?
absolute: Na channels are closed, no action potential
relative: need a greater stimulation since not at -70
Why does Myelin sheath results in faster conductance?
because the signal can hope from node to node of Ranvier, as signal is not dissipated.
CNS is composed of?
Brain and spinal cord