Nervous system Flashcards
overall functions of the NS
NS
to transmit info rapidly
to gather input and respond accordingly
3 main functions of the 5 main parts of the nervous system
NS
Sensory input - sensory receptor, sensory neurons
integration - CNS including interneurons
motor output - efferent/motor neurons, effector cells (muscle cells)
describe sensory input, integration, motoar output
NS
input - detection of stimulus
integration - processing in brain
output - response in another bodypart
CNS vs PNS
NS
CNS - Brain, spinal cord
PNS - efferent, afferent neurons, all other neurons not in CNS
what are the subdivisions of the PNS
NS
Sensory division - sensing external, sensing internal
Motor division -autonomic (parasympahteic, sympathetic) , somatic
Atonomic vs somatic in PNS
NS
Autonomic - involulntary reactions,signals to smooth msucle, cardiac muscle
somatic - voluntary reactions, signals go to skeletal muscle
sympathetic vs parasympathetic
NS
symp - arousal and eng gen, increase stress response, inhibit digest
parasymp - calming, decrease heart, stimulate digestive
types of senses
external: somatic(skin, muscle, joints), special(vision, hearing, equilibrium)
internal: visceral(fullness of stomach, blood pressure)
NS
Types of sensory receptors by location
NS
Exteroreceptors - detect stimuli from outside
interoreceptors - detect stimuli from inside body (viscerla senses)
Types of sensory receptors by stimulus
5
NS
mechanoreceptor - pressure (in skin, stomach, bladder)
photo - light (eyes)
chemoreceptor - chemcials (nose, mout, brain, arteries)
thermo- temp(skin, organs)
nociceptor - pain (skin, organs, glands, vessels)
NS
what are the 5 components of neuron also funct
dendrites - gets input from other neurons
cell body - does metabolism, protein syth
axon hillock - where action potential starts
axon-sends info
synaptic terminal - contains/releases neurotransl
WHat is neuron
describe
NS
Structural and functional unit of nervous system
are excitable - can make large changes in membrane pot(electrical signals)
do not do cell division when mature
nerve cell = neuron
What are the types of neyrons
NS
sensory
interneuron(CNS)
motor neurons(stereotypical neuron)
What do sensory neurons do
NS
Afferent neurons
carries signals from sense recept to CNS
What do interneurons do
NS
association neurons
get signals from sensory neurons
deliver signals to outgoing neurons
can be excitatory or inhibitory
What do motor neurons do
NS
efferent neurons
carries signals out of CNS to effetor cells
What are supporting cells/ glial cells
3 types
90% of cells in nervous system
structural and metabolic support
astrocytes(CNS)
oligodendrocytes(CNS)
schwann cells (PNS)
What is blood brain barrier
and astrocyte use
NS
blood vessels completly sealed off by astrocytes- no electrical conduction
stop things from contaminating brain
uses active transport proteins instea of hole
Wha do schwann cells and oligodendrocytes do
wrap around axon
provide insulation for electrical impulses
layer cllaed myelin sheath
schwann is PNS
oligodendrocyte is CNS
Purpose of myelin sheath
NS
provide electricla insulation
makes impulse travel faster
like insulation around wires
has nodes of ranvier
Types of nerve ciruits
NS
Divergent
convergent
circular
describe divergent nerve circuit
NS
nerve impulse in one presynaptic neuron
nerve impulses in several prostsynaptic neurons
ex photoreceptors to many parts of brain
Describe convergent nerve circuit
NS
nerve impulse from many presysnaptic neurons
nerve impulse in one postsynaptic neuron
Describe circular nerve circuit
NS
Neurons connections go in loop
ex. processing and storying memroes
What is simplest type of nerve circuit
and describe it
NS
reflex arc - reglates reflex
involuntary response
integration happens in spinal cord
ex. knee jerk reflex, gag reglex
What are steps of reflex arc
NS
receptor
sensroy neuron
integration center
motor neuron
effector
What is voltage and membrane potential
Nerve sig
voltage - diff in elect potential between 2 point
Memb pot- voltage across a membrane , -70mV when resting
outside pos
inside neg
How is resting potential maintianed
3 ways
Nerve sig
Ion distribution
membrane permeabiliy
Na+/K+ pump
how does ion distribution help mainting resting pot
Nerve sig
large negative molec cannot cross memb
ex proteins, sulphate,
maintain neg on inside
How does membrane permeability aid keeping resting pot
Nerve sig
charged ions cannot directly diffuse
uses leak channels
does not determine direciton of flow
more K+ leak channels than Na+
K+ easier to leave
Chem grad vs elect grad
Nerve sig
chem - concentration gradient, move from high to low concentration
(K out, Na In, Cl out )
elect - ion gradient, move from post to neg area
(K in, Na in, Cl out)
What is electrochemical gradient
also what is it for K and Na
Nerve sig
combination of both elect and chem gradient
K+ net move out of cell
Na+ net movement into cell
What is membrane potential if only K+ is used, what does this mean
Nerve sig
Equilibrium potential be -85mV
(potential at which there is no net movt of ion in or out)
this means that another cation is used to make it higher
Na+
What is effect of establishing equilibrium with only Na+ and K+
Nerve sig
influx of Na+ makes cell less neg
drives steady efflux of K+
concentration grad would dissipate
What is the role of Na+ K+ pump
Nerve sig
uses ATP to drive active trans to keep ionic gradient
3 Na out, 2 K in
more pos ions leaving cell than entering keeps it at -70Mv
What are the 3 types of potentials
Nerve sig
Graded (hyperpol, depol)
Threshold potential
action potential
Nerve sig
What is graded pot vs action pot
Nerve sig
graded - all membrane potentials lower than thresh pot
magnituge effected by strength of stim
magnit also from distance of stim
Action - large depol, triggered if depol reaches thresh pot, same mag all time (+35mV), only made in axon
hyperpolarization vs depolarization
Nerve sig
magnitude depend on strength of stim (opens more channels, larger change in pot)
hyperpol - lower than pesting pot (K+ channels open)
Depol - higher than resting pot (Na+ channels open )
What are diff types of ion channels
3
Nerve sig
ungated/leak - all over cell, always open, maintain rest pot
voltage gate - open/close due to memb pot, in action pot, synapses, in nodes of ranvier, and syn term
Chem gate - on/off due to chem, receptors when neurotrans bind, at dendrites
What are 5 phases of action pot
also ion permeabiliyt
Nerve sig
- resting - only Nin open
- threshold - some Nact open
- depol - K open slow, Nact all open, Nin close slow
- repol - K all open, Nact open, nin all closed
- undershoot - K close slow, both Na Closed
Nin = Na inhibition
Nact = Na activation
all are voltage gates
Na inactivation gate vs activation
Nerve sig
inact - on inside end of channel , slow
activ - on outside end of channel, fast
what is process of propegation
Nerve sig
when action pot travels along axon, repeated regen
depol causes neighbor to depol
goes one way
What is refractory period how does it effect propogation
Nerve sig
period where action pot is not possible,
Na inactivation gate too slow, still closed
during repol and undershoot phase
stops propogration from moving backwards
limits freq of act pot
factors affecting speed of conduction
Nerve sig
axon diamter - larger = faster, less res
myelination - no action pot between nodes, like it jumps