Nerve Injuries Flashcards
What are the layers that divide nerve fascicles and trunks?
- Perineurium
- Endoneurium
- Epineurium (trunk)
- Mesoneurium
What is the function of the connective tissue and fluid in nerve trunks?
Provides a blood/nerve barrier that filters out substances that may interfere with neural conduction
What is axoplasm?
- Fluid inside the cell body
- Provides nutrition, lubrication & cushioning
- Highly viscous
- Thixotropic (must be moved, otherwise becomes very thick)
What are terminal boutons?
At the end of axons, can be receptors or motor end plates
What does antegrade and retrograde refer to?
Axoplasmic flow:
Antegrade: Axoplasm flows away from the centre to the periphery
Retrograde: Axoplasm flows from the periphery to the centre
What is axoplasmic flow powered by?
Mitochondria
What does axoplasmic flow allow?
Maintenance factors & chemical mediators to travel up & down the nerve keeping the nerve healthy
What are the disadvantages of axoplasmic flow?
When a nerve becomes sick/pinched & inflamed, chemical mediators can hang around for a long time
What are nerves supplied by?
- Blood vessels
- Their own nerves (nervi nervorum)
What is the implication of nerves being supplied by nervi nervorum?
The nerve itself can become a source of pain, not just a conductor of pain
What are the 2 types of peripheral nerves?
- Myelinated (A alpha, A beta, A delta)
- Unmyelinated (C fibres)
What are some of the causes of peripheral nerve injury & disease?
- Trauma (direct pressure/blow or repetitive microtrauma)
- Chronic entrapment (e.g. CTS)
- Hereditary
- Infection
- Inflammation
- Ischaemic
- Toxic metabolic
What are the 3 types of traumatic peripheral nerve injuries?
- Neuropraxia
- Axonotmesis
- Neurotmesis
What are the features of neuropraxia?
- Focal damage of myelin fibres
- Axon/connective tissue intact
- Transient disruption of conduction
- Recovery days-weeks
What are the features of axonotmesis?
- Disruption of axon
- Connective tissue in tact
- Wallerian degeneration
- Axonal regeneration over months-years