Nerve Flashcards
Functional junction between 2/more neurons
Synapses
Consist of presynaptic neurons + postsynaptic neuron
Synapses
Characteristics of electrical synapses
-Gap junctions
-Makes functioning as a syncytium possible
Metabolic signals
-Found in cardiac and many types of smooth muscle
-Found in neural circuits such as arousal from sleep,emotions and memory
-Currently accepted as a complimentary form of communication
Areas of low resistance thar allows ionic flow of local current between adjacent cells via connexons in cell membrane
Gap junctions
Functional groups if neurons that integrate incoming information with an output
Neural pools
3 examples of how circuits can be configured
Convergent
Divergent
Reverberating
Stimulation of a single presynaptic neuron from multiple inputs, resulting in either strong stimulation or inhibition
Convergent
One incoming fiber stimulates ever increasing number of fibers, often amplifying circuits
Divergent
Are high divergence ratios possible with electrical synapses
No
Chain of neurons containing collateral synapses with previous neurons in the chain
Reverberating
Where synaptic delay is ~0.5ms
Auto receptors on surface of presynaptic neuron?
Provide negative feedback of the transduction process
Criterion used to identify neurotransmitter?
Present in appreciable concentration+ presence of enzymes for it’s synthesis
Chemically identified
Application on postsynaptic cell must mimic presynaptic stimulation
Response must be blocked in a dose dependent manner by an antagonist
Evidence of an enzyme system for degration
Major Neurotransmitters in the body
Dopamine the neurotransmitter that produces feeling of pleasure when released by the brain
Acetylcholine transmitter used by spinal cord neurons to control muscles and by many neurons in the brain to regulate memory
GABA major inhibitory neurotransmitter in the brain
Glutamine the most common excitatory neurotransmitter in the brain
Glycine a neurotransmitter used mainly by neurons in the spinal cord
Norepinephrine acts as a neurotransmitter and a hormone.
2 categories of receptors
Ionotropic receptor- channel linked
5 large protein complexes form ionic pores in membrane( amino acids sequence ‘controls’ the type of ion that moves through the pore)
Metabotropic receptors(G protein linked) Smaller domain single polypeptide comprising 7 alpha helices)