Nephrotic Syndrome Flashcards
Disorders
Membranous glomerulopathy
Minimal change disease
Membranopoliferative glomerulonephritis
Focal segmental
Causes of Membranous glomerulopathy
Hep B
Drugs (penicillamine, captopril, gold)
SLE
Tumors
Pathogenesis of MG
Immune complex mediated
Microscopy of MG
LM: basement membrane thickening
IF: granular mebranous deposits
EM: subepithelial deposits dome like and effacement of podocytes
MCD causes
May follow respiratory infection/vaccine
Common in children
NSAIDS
HOGHKINS
MCD pathogenesis
T cell mediated /unknown
Microscopy of MCD
LM: normal
IF:negative
EM: effacement of podocytes
Most common in children
MCD
Most common in adults
FSG
Causes of FCG
Hiv
heroin addiction
Sickle cell disease
Obesity
Pathogenesis of FSG
T cell mediated
Microscopy of FSG
LM: Focal scelrosis, hyalinodid, lipod droplets and foam cells
IF: NEGATIVE/ non specific positivity foe igm and c3
EM: diffuse effacement of podocytes and epithelial cell detachment
Microscopy of FSG
LM: Focal scelrosis, hyalinodid, lipod droplets and foam cells
IF: NEGATIVE/ non specific positivity foe igm and c3
EM: diffuse effacement of podocytes and epithelial epithe
MPG causes
HEP C
SLE
a antitrypsin defeciency
10% cases of Nephrotic syndrome in YA
MPG