Nephrotic Syndrome Flashcards

1
Q

Disorders

A

Membranous glomerulopathy
Minimal change disease
Membranopoliferative glomerulonephritis
Focal segmental

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2
Q

Causes of Membranous glomerulopathy

A

Hep B
Drugs (penicillamine, captopril, gold)
SLE
Tumors

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3
Q

Pathogenesis of MG

A

Immune complex mediated

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4
Q

Microscopy of MG

A

LM: basement membrane thickening

IF: granular mebranous deposits

EM: subepithelial deposits dome like and effacement of podocytes

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5
Q

MCD causes

A

May follow respiratory infection/vaccine
Common in children
NSAIDS
HOGHKINS

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6
Q

MCD pathogenesis

A

T cell mediated /unknown

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7
Q

Microscopy of MCD

A

LM: normal

IF:negative

EM: effacement of podocytes

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8
Q

Most common in children

A

MCD

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9
Q

Most common in adults

A

FSG

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10
Q

Causes of FCG

A

Hiv
heroin addiction
Sickle cell disease
Obesity

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11
Q

Pathogenesis of FSG

A

T cell mediated

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12
Q

Microscopy of FSG

A

LM: Focal scelrosis, hyalinodid, lipod droplets and foam cells

IF: NEGATIVE/ non specific positivity foe igm and c3

EM: diffuse effacement of podocytes and epithelial cell detachment

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12
Q

Microscopy of FSG

A

LM: Focal scelrosis, hyalinodid, lipod droplets and foam cells

IF: NEGATIVE/ non specific positivity foe igm and c3

EM: diffuse effacement of podocytes and epithelial epithe

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13
Q

MPG causes

A

HEP C
SLE
a antitrypsin defeciency

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14
Q

10% cases of Nephrotic syndrome in YA

A

MPG

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15
Q

MGN Type 1 pathogenesis

A

Immune complex mediated

16
Q

MGN Type 2 (DDD) Pathogenesis

A

Alternate complement pathway

17
Q

LM of MPG

A

Tram track appearance/ double contouring

Basement memrane thickening

18
Q

Microscopy of MPG type 1

A

IF: granular membranous IgG and C3

EM: subendothelial deposits

19
Q

Microscopy of DDD

A

IF: membranous granular/linear C3

EM: Intramembranous deposits + effacement of podocytes + permeation of lamina densa