Nephritic Syndrome Flashcards
Disorders
Acute proliferative / post streptococcal glomerulonephritis
Cresentric glomerulonephritis
APG/Post straptococcal target Age
1-6yrs
APG causes
Exogenous: HIV, malaria, straptococcal
Endogenous: SLE
APG Microscopy
LM: hypercellularity due to leukocyte infiltration and proliferation of endothelial and mesangial cells
IF: granular membranous/mesangial IgA IgM
IgG C3 post infection
EM: subendothelial deposits called HUMPS
Pathogenesis of APG
Immune complex mediated
Types of RPGN
Type 1- Anti GBM
Type 2- immune complex mediated
Type 3- pauci immune
Features of RPGN
Progressive loss of renal function
Oligouria
Nephritic Syndrome
Features of RPGN
Progressive loss of renal function
Oligouria
Nephritic Syndrome
Good pastures syndrome
Anti GBM disease with Hemoptysis
Due to antigen against noncollagenous portion of alpha 3 chain or Collagen type 4
Type 1 RPGN features
IF: Linear membranous IgG and C3
EM: rupture of GBM
Type 2 RPGN features
IF: Granular
EM: ELECTRON dense deposits and rupture of GBM
Wegners Granulomatosis
Upper and lower respiratory tracts + kidney disease
Type 3 RPGN features
IF negative
Rupture of GBM
Bergers disease/ IgA nephropathy
Effects YA
IgA deposits and recurrent hematuria
Pathogenesis of IgA nephropathy
Immune complex mediated
