Nephrotic/Nephritic Buzzwords

Question 1

Effacement of foot processes on EM in an adult

Answer 1

focal segmental glomerulosclerosis

Question 2

Effacement of foot processes on EM in a kid

Answer 2

minimal change disease

Question 3

Segmental sclerosis and hyalinosis on LM

Answer 3

focal segmental glomerulosclerosis

Question 4

Spike and dome appearance with sub epithelial deposits on EM

Answer 4

membranous nephropathy

Question 5

Diffuse capillary and GBM thickening (LM)

Answer 5

membranous nephropathy

Question 6

Congo red stain shows apple green birefringence under polarized light

Answer 6

amyloidosis

Question 7

Tram track appearance due to GBM splitting

Answer 7

Type 1 MPGN

Question 8

Intramembranous IC dense deposits

Answer 8

Type 2 MPGN

Question 9

Associated with C3 nephritic factor

Answer 9

Type 2 MPGN

Question 10

Associated with HBV, HCV

Answer 10

Type 1 MPGN

Question 11

Associated with HIV, sickle cell, heroin abuse

Answer 11

focal segmental glomerulosclerosis

Question 12

Associated with Ab to phospholipase A2 receptor

Answer 12

membranous nephropathy

Question 13

Nephrotic presentation of SLE

Answer 13

membranous nephropathy

Question 14

Associated with Hodgkin lymphoma in a kid

Answer 14

minimal change disease

Question 15

Associated with multiple myeloma, TB, and rheumatoid arthritis

Answer 15

amyloidosis

Question 16

Granular with subendothelial immune complex deposition (IF)

Answer 16

type 1 MPGN

Question 17

Kimmelstiel-Wilson lesions and mesangial expansion

Answer 17

diabetic glomerulonephropathy

Question 18

lumpy bumpy (IF)

Answer 18

acute post strep GN

Question 19

Subepithelial immune complex humps (EM)

Answer 19

acute post strep GN

Question 20

Associated with increased anti-DNase B titers and decreased complement levels

Answer 20

acute post strep GN

Question 21

Proteinuria in nephrotic syndrome is >___ per day

Answer 21

3.5g

Question 22

Crescent moon shape (LM, IF)

Answer 22

rapidly progressive glomerulonephritis

Question 23

IgG, IgM, C3 deposition along GBM and mesangium

Answer 23

acute post strep GN

Question 24

Antibodies to GBM and alveolar basement membrane

Answer 24

Goodpasture syndrome

Question 25

MCC death in SLE

Answer 25

diffuse proliferative glomerulonephritis

Question 26

Capillary wire looping (LM)

Answer 26

diffuse proliferative glomerulonephritis

Question 27

Subendothelial and sometimes intramembranous IgG-based immune complexes often with C3 deposition (EM)

Answer 27

diffuse proliferative glomerulonephritis

Question 28

IgA-based IC deposits in mesangium

Answer 28

IgA nephropathy (Berger disease)

Question 29

Seen with Henoch-Schonlein purpura

Answer 29

IgA nephropathy (Berger disease)

Question 30

Thinning and splitting of GBM with deafness and sometimes eye problems

Answer 30

Alport syndrome

Question 31

c-ANCA +

Answer 31

Wegeners (granulomatosis with polyangiitis)