Nephritic Syndrome Flashcards
What are nephritic syndromes?
Glomerulonephritic pathologies that cause both haematuria and proteinuria
What happens in nephritic syndromes?
Increased permeability of glomeruli allows movement of RBCs in to filtrate
How does nephritic syndrome present?
Oedema, visible haematuria, HTN, oliguria, uraemic signs, fever, tachycardia
How much protein is there in urine?
1-3.5g a day, less than nephrotic
How many RBCs are there in urine?
5 RBCs per microlitre on microscopy
What can cause nephritic syndrome?
IgA nephropathy, SLE, Henoch-Schonlein purpura, Poststreptococcal GN, IE
What is the first line investigation?
Urinalysis - will find blood and protein
What is the gold standard investigation?
Renal biopsy
What will you find on a renal biopsy?
Crescent shaped glomeruli, Ig depositions, glomerulosclerosis
How do you manage nephritic syndrome generally?
HTN control, proteinuria control
How can you control proteinuria?
ACEi/ARB, loop diuretic like furosemide, prednisolone
What do you add for poststreptococcal NS?
Penicillins
What do you add for Goodpasture’s?
Plasmapheresis
What do you add for SLE?
Monoclonal antibodies
What are the key presentations in nephritic syndrome?
Proteinuria, Haematuria, HTN
