Nephritic Case Studies

Question 1

LN Class 1 and Class 2

LM/IF/EM

Answer 1

1- normal, mesangial, mesangial

2- mesangial all 3

Question 2

LN Class 3 and 4

LM/IF/EM

Answer 2

3- focal prol, mesang cap loop, mes, sudendo

4- diffuse prolif, all the rest same

Question 3

LN Class 5 and 6

LM/IF/EM

Answer 3

5- thick GBM, Cap loop. Subepi, mes

6- GS,TA,IF/ +-/chronic changes

Question 4

LN Class 1 and Class 2 symptoms

Answer 4

1- normal UA, no/min proteinuria, normal creat

2- micro hematuria/proteinuria, no HTN

Question 5

LN Class 3 and 4 symptoms

Answer 5

Both= hematuria, proteinuria (nephrotic), HTN, dec GFR

Question 6

LN Class 5 and 6 symptoms

Answer 6

5- Nephrotic proteinuria, MH, HTN, norm creatinine

6- proteinuria/hematuria, dec GFR, ESRD

Question 7

Nephritic syndrome

Answer 7

HTN, hematuria, proteinurai

Question 8

ANCA Ab directed to antigens

CANCA
PANCA

Answer 8

on cytosol of neutrophil

C- bind ag in cytoplasm
P- bind ag in perinuclear region

Question 9

IgA nephropathy & complement

Answer 9

Alternative pathway in kidney

Serum levels are normal

Question 10

IgA and URI

Deposit where

Answer 10

After viral URI, IGA surge in production, including galactose deficient

Deposited in mesangium