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Path review > Neoplastic and aging diseases of mice > Flashcards

Neoplastic and aging diseases of mice Flashcards

1
Q

thymic LSA has a _____ incidence in ____ and ____ mice strains by 1 year and a high incidence in SCID mice

A
  • near 100%
  • AKR
  • C58
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2
Q

Which mouse strain has a high incidence of multicentric lymphoma

A

BALB/c mice

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3
Q

Histiocytic sarcoma
- Predisposed strains

  • Cell type of origin
A
  • Aged B6 and SJL mice
  • Kupffer cells and tissue macrophages
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4
Q

Gross findings of histiocytic sarcoma in mice

A
  • enlargement and nodularity to spleen, liver, uterus, vagina, kidney, lung, and/or ovaries
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5
Q

Associated findings of histiocytic sarcoma

A
  • erythrophagocytosis in HS arising from the liver
  • Eosinophilic inclusions in renal tubular epithelium
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6
Q

Rat mammary tumors are often ___-containing, while mouse mammary tumors are made up of

A
  • collagen
  • epithelial cells
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7
Q

Gross findings of mammary neoplasia in mice

A
  • often multicentric and multinodular, well-circumscribed (even if malignant)
  • pale tan, firm, and may have areas of hemorrhage
  • overlying skin may be ulcerated
  • pulmonary metastasis possible
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8
Q

Histopath findings of mammary neoplasia in mice

A
  • variably sized cystic structures lined by neoplastic glandular epithelium
  • cells are pleomorphic
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9
Q

Strain susceptibility to Mammary neoplasia

A
  • susceptible: C3H
  • Resistant: BALB/c
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10
Q

predisposing factors to Mammary neoplasia

A
  • MMTV, chemical carcinogens, and hormones influence incidence
  • Prolactin, progesterone, and estrogens influence development
  • Multiparous FVB mice are prone to mammary tumors
  • Stress induces mammary neoplasia in C3H/He mice
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11
Q

Pulmonary neoplasia
- cell type of origin

  • How do you classify adenoma vs. carcinoma
  • clinical signs
A
  • Arise from type II pneumocytes or Clara (club) cells
  • classification based on tumor size
  • usually no clinical signs
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12
Q

Strain susceptibility

A
  • near 100% incidence in A strain mice by 18-24 mos.
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13
Q

Predisposing factors to pulmonary neoplasia

A
  • enhanced incidence via Sendai virus or chemical carcinogens
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14
Q

Hepatocellular neoplasias are usually _________ or _____

What types are noted on histopath

A

hepatocellular adenomas or carcinomas

Note that there are trabecular or solid types on histopath

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15
Q

Strains predisposed to hepatocellular neoplasia

A
  • A and DBA strains
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16
Q

Predisposing factors to Hepatocellular neoplasia

A

Helicobacter associated with earlier onset and higher prevalence in A strain mice

17
Q

Harderian gland tumor
- Gross findings

  • histopath findings
  • behavior of neoplasm
A

gross:
- protrusion of the eye, porphyrin staining of periocular fur

Histopath
- lobulated, usually of papillary cystadenoma or solid adenoma morphology
- relatively well-differentiated epithelial cells with vacuolated cytoplams

behavior:
- adenocarcinomas are invasive but rare to metastasize

18
Q
  • Strains predisposed to osteomas and osteosarcomas
  • most common site for vertebral tumors
  • what virus can also lead to bone tumors in mice
A

strains
- NOD mice
- Outbred OF-1 and CF-1 mice develop benign bone tumors

Region:
- lumbosacral region is most common site for vertebral tumors

virus causing bone tumors
- PyV of nude mice

19
Q

Pituitary gland adenomas
- Predisposed strains

  • predisposed sex
  • hormone produced by tumor
A

strains:
- common in B6 and Swiss mice
- FVB/N mice are very prone

Predisposed sex: females

  • Hormone produce: prolactin
20
Q

Gross findings of pituitary gland adenomas

Histopath findings

A
  • large, pale tan to red, soft, well-demarcated mass, often very hemorrhagic

solid, sinusoidal, or cystic patterns on histopath

behavior: grow expansively with compression of the brain

21
Q

Stain of choice for amyloidosis

A

Congo red

22
Q

Amyloidosis:
- strains with high prevalence and early onset

  • Strains with high prevalence but late onset
  • strains that are rarely affected
A
  • A, SJL, and outbred Swiss mice
  • B6 and B10 mice
  • BALB/C3H, and DBA mice
23
Q

Strains predisposed to Soft tissue calcification

A
  • BALB/c (right ventricular epicardial mineralization)
  • C3H (Myocardium and ventricles and IVS, axial skeletal muscles)
  • DBA (heart and many other organs)
24
Q

You find acidophilic crystals accumulated with macrophages MNGCs, alveolar spaces, and airways. What is your first thought?

What are these crystals comprised of?

A

Acidophilic macrophage pneumonia

  • Ym1 and Ym2 chitinase, with iron, alpha-1 antitrypsin
25
Q
  • Strains predisposed to acidophilic macrophage pneumonia
  • predisposing factors°°
A
  • B6, 129, and Swiss mice
  • response to inflammation and/or diminished pulmonary clearance
26
Q

You find similar crystals in the cytoplasm of olfactory, nasal respiratory, middle ear, trachea, lung, stomach, gallbladder, bile duct, and pancreatic duct epithelium. Now what do you call it?

A

“Epithelial hyalinosis”

27
Q

What are some causes of hair loss in mice

A
  • Barbering and trichotillomania (compulsive behavior/dominance issue)
  • mechanical muzzle alopecia (improper food/watering tool use)
  • Alopecia areata in C3H mice (autoimmune response)
  • Alopecia of B6 mice (multifactorial and behavioral disorder)
  • Clown syndrome (MHV infection on young mouse caused arrested hair follicle growth)
28
Q

Common cause of Auricular chondritis

A
  • autoimmune disease response to metal ID tagging
29
Q

Causes of Gangrene of ears and limbs

A
  • erosive inflammation and necrosis of pinnal margins (ears)
  • Sloughing of extremeties due to cotton nesting material (limbs)
  • frostbite (limbs, nude mice more at risk)

Ringtail (caused by low humidity and high temperature)

30
Q

Hydrocephalus is relatively common in _____strains

A

C57BL strains

31
Q

Acallosity and hypocallosity are common in which strains

A
  • BALB/c and 129 mice
32
Q

Microphthalmia/anophthalmia is common and unique to ____ mice strains

_____ are predisposed and it is usually _____, affecting the ______

A
  • C57BL
  • females
  • asymmetric
  • affecting the right eye
33
Q

Which auricle is usually affected by atrial thrombosis

what are some predisposing factors

which strain is predisposed

A

the left auricle

predisposing factors:
- usually 2° to amyloidosis or renal disease

predisposed strain
- BALB/c

34
Q

Murine Urologic Syndrome affects which strains predominantly

A

B6C3F1 and ICR strains

35
Q

Pathogenesis of MUS

gross findings

A

proteinaceous plugs of ejaculate lodged in neck of urinary bladder or proximal urethra -> obstructive uropathy

urinary bladder distention, possible hydronephrosis

Path review (9 decks)

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