Hamster neoplastic and non-infectious dz Flashcards
What is the genus and species of the Syrian hamster
Mesocricetus auratus
What is the #1 neoplastic disease of Syrian Hamsters?
Likely causative agent? What other disease can be caused by it?
Lymphoma
HaPyV; trichoepithelioma
How does the maternal antibody protection influence disease presentation in a colony that is endemic for HaPyV
- dz begins as epizootic w/ minimal resistance –> many hamsters get lymphoma and die –> surviving mothers pass on to offspring, protect them from developing lymphoma –> hamsters will develop trichoepitheliomas if infected later in life (endemic infection)
What stain do you use for amyloidosis in hamsters? What additional lighting can use use for visualization
Congo red; polarized light causes the stain to light with green bifringence
What types of amyloid do hamsters make?
AA and AP
Which sex is more predisposed to amyloidosis? why
- females
- they have higher levels of AP (AKA FP)
How can you experimentally induce amyloidosis
- casein or LPS injections
Which organs can be affected by polycystic disease
- liver, ovaries
Clinical signs of liver cirrhosis
cause
which sex is more prone
- no clinical signs, more of an incidental finding
- unknown cause, suspected to be related to diet, bacterial pathogens, immune system disorders
- females
How is nephrotic syndrome connected w/ amyloidosis and atrial thrombosis
severe renal amyloidosis –> hypoalbuminemia, proteinuria –> ascites, anasarca
Severe renal amyloidosis –> antithrombin III loss –> hypercoagulable state –> thrombus formation
Spontaneous neoplasia in European hamsters is more common in male or female hamsters?
males
What kinds of spontaneous neoplasia can occur in European hamsters?
- Leukemias/Lymphomas
- Adrenal pheochromocytomas
- Granulosa cell tumors
Causative bacteria for fistulated abscesses in European hamsters
- staphylococcus
- p. pneumotropica
- p. multocida
What is the demodex mite of Armenian hamsters
Demodex cricetuli
